Muscle cell fatuige

Give an explanation as to why decreasing pH in the muscle might decrease force. Give some evidence as to why this cant be the only factor affecting fatigue.

Glycolysis is affected by ____ as hexokinase and PFK are inhibited.

Give some evidenced to suggest why PCr decrease is not the reason for fatigue?

Give a good indicator of fatigue.

As we exercise Pi _____. This _____ the action of cross bridge cycling so muscles move to a low ____ state when Pi is high.

Describe what happens when we maximally stimulate fatigued muscles compared to sub maximal stimulation.

What does increasing the stimulation frequency do in relation to calcium ions

When we are fatigued we need _____ stimulation for the same sub maximal force.

When we are fatigued we need _____ stimulation for the same sub maximal force.

When we are fatigued but can still create maximal contraction force, what does this show about the muscle structure?

If we can still create maximal force, why do we encounter problems with fatigued muscle in every day life?

Give some evidence that low frequency fatigue is not due to excitation failure.

What is the cause of low frequency fatigue?

What kind of exercise are we most likely to experience low frequency fatigue? What is the result of low frequency fatigue is the proceeding days?

What happens to the relaxation in muscles experiencing low frequency fatigue?

Give reasons why Ca+ energetics are unlikely to explain slowing of muscle relaxation. Suggest alternative reasons.