Parkinsons epidemiology: prevalence is [blank_start]0.5-1[blank_end]% in the UK in >[blank_start]60[blank_end]'s. it is the second most common neurodegenerative disorder after alzeheimers. the mean age of onset is [blank_start]45-60[blank_end] but it can occur in people as young as [blank_start]30[blank_end]. there are [blank_start]120,000[blank_end] people living with parkinsons in the UK.
Answer
0.5-1
1-1.5
1.5-2
2-2.5
60
50
70
80
45-60
50-65
55-70
60-75
30
20
25
35
120,000
100,000
80,000
140,000
Question 2
Question
which of the following is not a cause of parkinsons
Answer
heavy metal exposure
pesticide exposure
repeated head trauma
idiopathic
MPTP
genetics
excessive alcohol
Question 3
Question
parkinsons results from the loss of [blank_start]dopaminergic neurons[blank_end] in the [blank_start]basal ganglia[blank_end] most notably the [blank_start]substantia nigra[blank_end] which usually synthesises [blank_start]dopamine[blank_end]. surviving neutrons contain aggregations of protein ([blank_start]alpha-synuclein[blank_end]) called [blank_start]lewy bodies[blank_end]. symptoms are only seen once levels of dopamine are [blank_start]20-40%[blank_end] of normal. the disease is slowly progressive without remission.
Answer
dopaminergic neurons
basal ganglia
substantia nigra
dopamine
alpha-synuclein
lewy bodies
20-40%
Question 4
Question
which of the following is not part of the classic triad for parkinsons?
Answer
tremor
rigidity
bradykinesia
ataxic gait
Question 5
Question
which of the following is not a symptom of parkinsons?
Answer
loss of sense of smell
slurred slow speech
plain face
depression
dementia
hallucinations
REM sleep disturbance
difficulty swallowing
sluggish bowel and bladder
vertical gaze palsy
Question 6
Question
what is the name of the scan that can be used to diagnose dementia? [blank_start]DAT[blank_end]
Answer
DAT
Question 7
Question
mark on the DAT scan which is normal and which is abnormal
what is the name of the criteria that can be helpful is diagnosing parkinsons? [blank_start]brain bank[blank_end]
Answer
brain bank
Question 9
Question
In younger patients you would start by treating them with L-dopa instead of dopamine agonists
Answer
True
False
Question 10
Question
match each of the following types of parkinsons medication to the examples:
l-dopa - [blank_start]madapar[blank_end]
selective dopamine agonist - [blank_start]pramipexole[blank_end], [blank_start]bromocriptine[blank_end]
increases dopamine release - [blank_start]amantadine[blank_end]
MAO-B inhibitors - [blank_start]selegilene[blank_end]
COMTI - [blank_start]tolcapine[blank_end]
Answer
madapar
pramipexole
bromocriptine
amantadine
selegilene
tolcapine
Question 11
Question
never prescribe haloperidol for a parkinsons patients
Answer
True
False
Question 12
Question
which of the following is not a treatment for parkinsons?