Purines and Pyrimidines

Question

A rapidly dividing cell will have a greater abundance of which nucleotide?

Answer 1

Guanine and Adenine because purine synthesis is more important for a developing cell

Answer 2

Cytosine and Thiamine because pyrimidine synthesis is less taxing and therefore proceed more quickly

Answer 3

The concentration of pyrimidines and purines will be equal regardless of the conditions

Answer 4

Purines are critical for DNA replication, so purine concentration will be higher

Answer 5

Image:

275px-Desoxyadenosin.svg (image/png)

Answer 6

Image:

138px-Adenin.svg (image/png)

Answer 7

Image:

DAMP_chemical_structure (image/png)

Answer 8

Image:

239px-Desoxyuridin.svg (image/png)

Answer 9

It was the only answer that consisted of a nucleoside bound to a phosphate group

Answer 10

All of the other answers were sugars

Answer 11

All of the other answers were bases

Answer 12

None of the other answers were biologically important molecules

Answer 13

They are precursors to glycogen and other phosphoglycerides

Answer 14

Nucleotides exclusively compromise the universal energy currency

Answer 15

They serve as metabolic regulators and mediate the action of many hormones

Answer 16

Nucleotides entirely make up three major co-enzymes: NADH, FAD, and CoA

Answer 17

carbon dioxide

Answer 18

Formyltetrahydrofolate

Answer 19

All of the above are required atom contributors

Answer 20

purine de novo synthesis and purine salvage pathways

Answer 21

purine de novo synthesis

Answer 22

purine salvage

Answer 23

purine and pyrimidine de novo synthesis

Answer 24

Glutamine-PRPP amido-transferase is the active enzyme

Answer 25

PRPP feeds into the committed step

Answer 26

Glutamine feeds into the step and becomes glutamate

Answer 27

All of the above

Answer 28

Eliminates an amide group

Answer 29

Transfers one carbon from N10-Formyl THF to the growing purine precursor

Answer 30

Allosterically activates HGRPT

Answer 31

Facilitates a Glutamine dependent nitrogen tranfer

Answer 32

Facilitates ring closure of the growing purine

Answer 33

Inosinic Acid (IMP) is the nucleoside form of hypoxanthine

Answer 34

Hypoxanthine is critical only to the conversion of IMP to GMP not IMP to AMP

Answer 35

Hypoxanthine is reduced to xanthine during the purine synthesis pathway

Answer 36

The oxidation of hypoxanthine to xanthine is blocked by allpurinol

Answer 37

De novo synthesis of purines

Answer 38

Direct production of IMP through PRPP's reaction with Hypoxanthine

Answer 39

Direct production of GMP through PRPP's reaction with Guanine

Answer 40

All of the above are catalyzed by HGPRT and all are true in healthy cells

Answer 41

ADA (adenosine deaminase)

Answer 42

PNP (purine nucleoside phosphorylase)

Answer 43

You have to be more specific, gout could be the result of numerous enzyme deficiencies

Answer 44

XO (xanthine oxidase)

Answer 45

XO (xanthine oxidase)

Answer 46

ADA (adenosine deaminase)

Answer 47

You have to provide more information, Lesch Nyhan Syndrome could be caused by the deficiency of a number of different enzymes

Answer 48

Aspartate Transcarbamoylase ATCase

Answer 49

Dihydroorotase

Answer 50

CTP synthetase

Answer 51

There is no curative treatment, simply a management of symptoms

Answer 52

Delivery of large doses of orally administered uridine to simply bypass the early steps of pyrimidine synthesis

Answer 53

Delivery of large doses of the missing/deficient orotate phosphoribosyltransferase (OPRT)

Answer 54

Delivery of fully synthesized pyrimidines for uptake into the cell

Answer 55

Ribosomyl Reductase

Answer 56

PRPP Synthetase

Answer 57

Xanthine Oxidase

Answer 58

Dihydrofolate Reductase

Answer 59

Amidophosphoryl Transferase ATase = glutamine PRPP amidotransferase

Answer 60

I should probably know all of these

Answer 61

Because Carl Sagan's famous Apple Pie from scratch comment makes it too awesome to use in any setting other than musing about the universe

Answer 62

Because De Novo is more descriptive

Answer 63

To confuse those who are sadly lacking in medical jargon

Answer 64

Because fancy language is awesome

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Purines and Pyrimidines

Description

Resource summary

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10

Question 11

Question 12

Question 13

Question 14

Question 15

Question 16

Question 17

Question 18

Question 19

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	Created by Peter Seymour about 10 years ago