Pancreatic insufficiency

Promote optimal digestion by supporting breakdown and absorption of nutrients

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Support production of pancreatic enzymes via nutritional precursors and cofactors

Stimulate release of pancreatic enzymes by activating the vagal nerve and CCK via eating habits and bitters

Create an environment in the SI lumen which facilitates pancreatic enzyme function - pH 5.9. Increase gastric secretions and bicarbonate

Support pancreatic tissue integrity via increasing enzymes for digestion and recycling

Increase repair of pancreatic tissue by reducing damaging factors such as oxidative stress and inflammation

Correct side effects of poor enzyme levels - dysbiosis, food allergies, nutritional insufficiencies (especially fat soluble insufficiencies).

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Nervous system activity - manage stress levels Impact on liver function - decrease nutritional status and increased workload from the GIT

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Pancreatic enzymes are natural chemicals that help break down fats, proteins and carbohydrates. A normally functioning pancreas secretes about 8 cups of fluid, called pancreatic juice, daily into the duodenum, the portion of the small intestine that connects with the stomach. This fluid contains pancreatic enzymes and helps neutralize stomach acid as it enters the small intestine

Lipase: Lipase works with bile from the liver to break down fat molecules so they can be absorbed and used by the body. A shortage of Lipase may cause; Lack of needed fats and fat-soluble vitamins. Diarrhea and/or fatty stools.

Proteases: Proteases break down proteins. They help keep the intestine free of parasites such as bacteria, yeast and protozoa A shortage of protease may cause; Allergies or the formation of toxic substances due to incomplete digestion of proteins. Increased risk for intestinal infections.

Amylase: Amylase breaks down carbohydrates (starch) into sugars which are more easily absorbed by the body. This enzyme is also found in saliva. A shortage in Amylase may cause: Diarrhea due to the effects of undigested starch in the colon.

Vegetable enzymes: These are microbe derived enzymes and contain a mixture of lipase, amylase, protease, and lactase which are used in the breakdown of each macro nutrient They are effective over a wider pH range

Bromelain: Bromelain is derived from pineapple from the fruit and the stem. It is a protelytic enzyme which hydrolyzes proteins to oliopeptides and amino acids. Take with food to aid protein digestion. It operates in a broad pH range It is also antioxidant and anti-inflammatory

Papain: Derived from papaya fruit It is also a proteolytic enzyme

Zinc is an anti-oxidant which reduces oxidative stress which contributes to pancreatic damage. Zinc is needed for pancreatic tissue and enzyme production. Deficiency is associated with impaired exocrine function. Pancreatic enzyme insufficiency decreases the absorption of zinc, creating a vicious cycle.

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Selenium

Vitamin C

Vitamin E

beta carotene

Yes, they need to be replenished due to malabsorption

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yes - if production is decreased and or reduced stimulus for release

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Yes- In exocrine pancreatic insufficiency, undigested fat is passed in the stool, causing greasy, foul-smelling, loose stools. A low fat diet can also reduce pain associated with pancreatitis.

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Chew food thoroughly in order to stimulate the cephalic phase of digestion (secretion release) and don't over eat.

Include protein in each meal and bitters in diet