Question 1
Question
Which trafficking pathway is highlighted in the picture?
Answer
-
Biosynthetic pathway
-
Endocytic pathway
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Secretory pathway
-
Nuclear export pathway
Question 2
Question
The depicted trafficking pathway is regulated by cellular signals.
Question 3
Question
Which experiment is a genetic approach to characterize the components and the molecular mechanism of the endomembrane system?
Question 4
Question
Which experiments make use of microsomes to study the endomembrane system?
Question 5
Question
Which is the organelle with the largest surface area?
Answer
-
Golgi
-
Endoplasmic reticulum
-
Plasma membrane
-
Nucleus
Question 6
Question
The signal sequence is a short stretch of [blank_start]hydrophobic[blank_end] amino acids at the [blank_start]N-terminus[blank_end] of a nascent protein that serves as an [blank_start]ER-targeting[blank_end] signal.
Answer
-
hydrophobic
-
hydrophilic
-
N-terminus
-
C-terminus
-
ER-targeting
-
nuclear export
-
Golgi-targeting
Question 7
Question
SRP stands for "[blank_start]signal recognition particle[blank_end]".
Question 8
Question
Which of the following is a multi-protein complex with an hour-glass shaped aqueous pore?
Question 9
Question
TMD stands for "[blank_start]transmembrane domain[blank_end]".
Question 10
Question
TMD is a short stretch of hydrophobic amino acids which serves as a [blank_start]stop transfer sequence[blank_end].
Question 11
Question
UPR ([blank_start]unfolded protein response[blank_end]) initiates pathways that lead to either the production of more chaperone protein or a global reduction in protein synthesis to alleviate ER stress.
Question 12
Question
The process in which misfolded proteins are shuttled out of the ER to the [blank_start]cytosol[blank_end] where the oligosaccharide chain is removed and the protein is degraded in the [blank_start]proteasome[blank_end] is called [blank_start]ERAD[blank_end] ([blank_start]ER-associated degradation[blank_end]).
Question 13
Question
During core modification of a glycoprotein, the last remaining glucose is removed by
Answer
-
Glycosidase I
-
Glycosidase II
-
Glycosidase III
-
Calnexin
Question 14
Question
UGGT is an ER chaperone which recognizes [blank_start]hydrophobic[blank_end] regions of misfolded proteins and tags them for refolding by adding back a [blank_start]glucose[blank_end] molecule.
Answer
-
hydrophobic
-
negatively charged
-
hydrophilic
-
glucose
-
fatty acid
Question 15
Question
In the endomembrane system, the new membrane can only arise from the existing membrane.
Question 16
Question
According to current knowledge, which of the following are not components of the endomembrane system?
Answer
-
Nucleus
-
Golgi
-
ER
-
Lysosome
-
Endosome
-
Clathrin-coated vesicle
-
Mitochondria