Protein trafficking

Description

Quiz on Protein trafficking, created by Chau Tran on 17/11/2019.
Chau Tran
Quiz by Chau Tran, updated more than 1 year ago
Chau Tran
Created by Chau Tran almost 5 years ago
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Resource summary

Question 1

Question
Which trafficking pathway is highlighted in the picture?
Answer
  • Biosynthetic pathway
  • Endocytic pathway
  • Secretory pathway
  • Nuclear export pathway

Question 2

Question
The depicted trafficking pathway is regulated by cellular signals.
Answer
  • True
  • False

Question 3

Question
Which experiment is a genetic approach to characterize the components and the molecular mechanism of the endomembrane system?
Answer
  • Cell-free systems
  • Live-cell imaging
  • Pulse-chase labelling
  • Mutant phenotype analysis

Question 4

Question
Which experiments make use of microsomes to study the endomembrane system?
Answer
  • Pulse-chase labelling
  • Cell-free systems
  • Subcellular fractionation
  • Live-cell imaging

Question 5

Question
Which is the organelle with the largest surface area?
Answer
  • Golgi
  • Endoplasmic reticulum
  • Plasma membrane
  • Nucleus

Question 6

Question
The signal sequence is a short stretch of [blank_start]hydrophobic[blank_end] amino acids at the [blank_start]N-terminus[blank_end] of a nascent protein that serves as an [blank_start]ER-targeting[blank_end] signal.
Answer
  • hydrophobic
  • hydrophilic
  • N-terminus
  • C-terminus
  • ER-targeting
  • nuclear export
  • Golgi-targeting

Question 7

Question
SRP stands for "[blank_start]signal recognition particle[blank_end]".
Answer
  • signal recognition particle

Question 8

Question
Which of the following is a multi-protein complex with an hour-glass shaped aqueous pore?
Answer
  • NPC
  • Sec61
  • SRP
  • Proteosome

Question 9

Question
TMD stands for "[blank_start]transmembrane domain[blank_end]".
Answer
  • transmembrane domain

Question 10

Question
TMD is a short stretch of hydrophobic amino acids which serves as a [blank_start]stop transfer sequence[blank_end].
Answer
  • stop transfer sequence

Question 11

Question
UPR ([blank_start]unfolded protein response[blank_end]) initiates pathways that lead to either the production of more chaperone protein or a global reduction in protein synthesis to alleviate ER stress.
Answer
  • unfolded protein response

Question 12

Question
The process in which misfolded proteins are shuttled out of the ER to the [blank_start]cytosol[blank_end] where the oligosaccharide chain is removed and the protein is degraded in the [blank_start]proteasome[blank_end] is called [blank_start]ERAD[blank_end] ([blank_start]ER-associated degradation[blank_end]).
Answer
  • proteasome
  • ERAD
  • ER-associated degradation
  • cytosol

Question 13

Question
During core modification of a glycoprotein, the last remaining glucose is removed by
Answer
  • Glycosidase I
  • Glycosidase II
  • Glycosidase III
  • Calnexin

Question 14

Question
UGGT is an ER chaperone which recognizes [blank_start]hydrophobic[blank_end] regions of misfolded proteins and tags them for refolding by adding back a [blank_start]glucose[blank_end] molecule.
Answer
  • hydrophobic
  • negatively charged
  • hydrophilic
  • glucose
  • fatty acid

Question 15

Question
In the endomembrane system, the new membrane can only arise from the existing membrane.
Answer
  • True
  • False

Question 16

Question
According to current knowledge, which of the following are not components of the endomembrane system?
Answer
  • Nucleus
  • Golgi
  • ER
  • Lysosome
  • Endosome
  • Clathrin-coated vesicle
  • Mitochondria
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