Question 1
Question
What enzyme partakes in the reversible reaction shown by the green question mark?
Answer
-
Phosphoglucose isomerase
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Enolase
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Aldolase
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Phosphofructo kinase
Question 2
Question
What enzyme partakes in the reversible reaction shown by the orange question mark?
Answer
-
Aldolase
-
Phosphoglucose isomerase
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Phosphoglycerate kinase
-
Enolase
Question 3
Question
What enzyme partakes in the reversible reaction shown by the red question mark?
Answer
-
Phosphoglycerate kinase
-
Enolase
-
Aldolase
-
Phosphoglucose isomerase
Question 4
Question
What enzyme partakes in the reversible reaction shown by the purple question mark?
Answer
-
Enolase
-
Aldolase
-
Phosphoglucose isomerase
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Phosphoglycerate kinase
Question 5
Question
What is the intermediate produced shown by the blue question mark?
Answer
-
3-Phosphoglycerate
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1-Phosphoglycerate
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1,3-diphosphoglycerate
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Succinate
Question 6
Question
What is the intermediate produced shown by the gray question mark?
Answer
-
Phosphoenol pyruvate
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1-Phosphoglycerate
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3-Phosphoglycerate
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Acetyl CoA
Question 7
Question
Define substrate level phosphorylation.
Answer
-
The generation of an energy rich phosphate bond resulting from the breakdown of a more energy rich substrate.
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The synthesis of ATP driven by the electron transport chain.
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The potential of a substance to donate its electrons.
Question 8
Question
Define oxidative phosphorylation
Answer
-
The synthesis of ATP driven by the electron transport chain.
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The formation of an energy rich phosphate bond from the breakdown of a more energy rich substrate.
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The potential of a substance to donate its electrons.
Question 9
Question
When is water produced in glycolysis?
Answer
-
2-Phosphoglycerate -> Phosphoenol pyruvate
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Glucose -> Glucose-6-phosphate
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Glyceraldehyde 3 phosphate -> 1,3-bisphosphoglycerate
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Fructose-6-phosphate -> Fructose-1,6-bisphosphate
Question 10
Question
A kinase enzyme catalyses the removal of a phosphate group from a molecule.
Question 11
Question
What molecule is shown by the red question mark?
Question 12
Question
What molecule is shown by the green question mark?
Question 13
Question
What molecule is shown by the purple question mark?
Question 14
Question
What molecule is shown by the orange question mark?
Question 15
Question
What molecule is shown by the blue question mark?
Question 16
Question
What intermediate does the red question mark show?
Question 17
Question
What intermediate does the blue question mark show?
Answer
-
Phosphoenolpyruvate
-
Oxaloacetate
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Citric acid
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Fumarate
Question 18
Question
What enzyme does the green question mark show?
Question 19
Question
What enzyme does the orange question mark show?
Answer
-
Pyruvate carboxylase
-
Pyruvate dehydrogenase
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Pyruvate anhydrase
-
Pyruvate carboxykinase
Question 20
Question
What cycle does the diagram show?
Answer
-
Cori cycle
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Krebs cycle
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Calvin cycle
Question 21
Question
Where is glucose converted to lactate in this cycle?
Answer
-
Skeletal muscle
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Liver
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Kidneys
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Adipose
Question 22
Question
Where is lactate converted to glucose in this cycle?
Answer
-
Skeletal muscle
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Liver
-
Kidneys
-
Adipose
Question 23
Question
The cori cycle uses more ATP in conversion of lactate to glucose than vice versa.
Question 24
Question
Von Gierke's disease leads to a deficiency in the enzyme glucose-6-phosphatase. How might this impact on glycogen levels in the liver?
Question 25
Question
Coenzyme A performs what function?
Answer
-
Activates acetyl groups so they can be transferred to other metabolites.
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Catalyse gluconeogenesis in the liver as part of the cori cycle.
-
Converts Pyruvate into Acetyl CoA
Question 26
Question
Pyruvate dehydrogenase complex is made up of what enzymes?
Answer
-
Pyruvate dehydrogenase
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Dihydrolipoyl transacetylase
-
Dihydrolipoyl dehydrogenase
-
Pyruvate carboxylase
-
Phosphoenolpyruvate carboxykinase
Question 27
Question
Vitamin B1 deficiency, sometimes known as "beri-beri" causes fatigue due to lack of pyruvate conversion into Acetyl CoA.
Question 28
Question
As well as pyruvate, fatty acids and amino acids can also be converted to Acetyl CoA
Question 29
Question
Acetyl CoA can be converted to Amino acids, explaining why a high carbohydrate diet can lead to high protein levels.
Question 30
Question
Electron loss during redox in the electron transport chain usually occurs when hydrogen is removed.
Question 31
Question
The less negative a substances redox potential, the greater the tendency to donate electrons.
Question 32
Question
Carriers of different redox potentials pass their electrons on to carriers with a less negative redox potential.
Question 33
Question
Loss of hydrogen indicates oxidation.
Question 34
Question
NADH has a less negative redox potential and therefore less ATP is generated from NADH's contribution to the ETC than FADH2.
Question 35
Question
What is the chemiosmotic coupling hypothesis?
Answer
-
The energy from electron transport drives the efflux of hydrogen ions from the matrix into the intermembrane space. This establishes a proton electrochemical gradient. ATP synthesis is driven by ATP synthase using this proton gradient (proton motor force).
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The energy from electron transport drives the efflux of hydrogen ions from the intermembrane space into the matrix. This establishes a proton electrochemical gradient. ATP synthesis is driven by ATP synthase using this proton gradient (proton motor force).
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The energy from electron transport drives the efflux of hydrogen ions from the matrix into the intermembrane space. This establishes a proton electrochemical gradient. ADP synthesis is driven by ADP synthase using this proton gradient (proton motor force).
Question 36
Question
What is meant by an uncoupled system such as brown adipose?
Answer
-
The H+ gradient generated by the energy that is released from the electron transport chain is dissipated as heat instead of being coupled to drive oxidative phosphorylation.
-
The energy released from the electron transport chain is dissipated as heat instead of being coupled to drive oxidative phosphorylation.
Question 37
Question
How does ATP synthase generate ATP?
Answer
-
It allows the proton gradient, established from the energy generated by the electron transport chain, to pass through the membrane and uses this kinetic energy to phosphorylate ADP into ATP.
-
ATP synthase phosphorylates ADP into ATP from the energy from the electron transport chain.
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ATP synthase phosphorylates cAMP into ATP using the proton gradient established from the energy from the electron transport chain.
Question 38
Question
NADH has direct access to reduce the electron transport chain.
Question 39
Question
Brown adipose is important in thermoregulation in neonats and for animals that hibernate.
Question 40
Question
How does an uncoupler such as dinitrophenol work?
Answer
-
It carrys the H+ back into the matrix therefore the proton gradient that is established is not used to make ATP via ATP synthase.
-
It blocks the ATP synthase membrane bound enzyme, therefore stopping oxidative phosphorylation.
Question 41
Question
What molecule is part of the glycerol phosphate shuttle and labelled by the red question mark?
Question 42
Question
What reduces the red question mark molecule to glycerol-3-phosphate?
Answer
-
NADH -> NAD+
-
FADH2 -> FAD+
Question 43
Question
What is the first membrane bound complex shown by the green question mark?
Answer
-
NADH-Q reductase
-
Cytochrome C
-
Succinate-Q reductase
-
Cytochrome C reductase
Question 44
Question
What is the second membrane bound complex shown by the red question mark?
Answer
-
Succinate-Q reductase
-
NADH-Q reductase
-
Cytochrome C
-
Cytochrome C reductase
Question 45
Question
What is the third membrane bound complex shown by the purple question mark?
Answer
-
Cytochrome reductase
-
Succinate-Q reductase
-
NADH-Q reductase
-
Cytochrome C
Question 46
Question
What name is given to the electron carriers labelled by the orange triangles?
Answer
-
Membrane bound carriers
-
Mobile carriers
-
Oxidising enzymes
-
Fluid carriers
Question 47
Question
ATP is produced during the krebs cycle.
Question 48
Question
How many molecules of NADH are produced during the krebs cycle?
Question 49
Question
Why can the krebs cycle not occur without O2?
Answer
-
Although the TCA/krebs cycle does not need O2 directly, regeneration of NAD+ and FAD depend upon O2 as a terminal electron acceptor at the end of the ETC. Without O2 as the terminal electron acceptor, the ETC cannot proceed as electrons are not being terminally accepted and thus FADH2 and NADH cannot reduce the ETC carriers as electrons are not passing through the system. Without NAD+ and FAD available, conversion of certain intermediates cannot occur in the TCA cycle but more importantly Glyceraldehyde-3-phosphate cannot be converted to 1,3-bisphosphoglycerate.
-
Although the TCA/krebs cycle does not need O2 directly, regeneration of NAD+ and FAD depend upon O2 as a terminal electron acceptor at the end of the ETC. Without O2 as the terminal electron acceptor, the ETC cannot proceed as electrons are not being terminally accepted and thus FADH2 and NADH cannot reduce the ETC carriers as electrons are not passing through the system. Without NAD+ and FAD available, conversion of certain intermediates cannot occur in the TCA cycle but more importantly 1,3-bisphosphoglycerate cannot be converted to Glyceraldehyde-3-phosphate.