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Cancer 2

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Cancer questions
ivenkat
Quiz by ivenkat, updated more than 1 year ago
ivenkat
Created by ivenkat almost 9 years ago
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Resource summary

Question 1

Question
Loss of WT-1 gene results in what cancer?
Answer
  • Neuroblastoma
  • Wilms tumor

Question 2

Question
All of the following are Autosomal recessive cancer predisposition disorders except?
Answer
  • Xeroderma Pigmentosum (XP)
  • Bloom syndrome
  • Fanconi anemia
  • Ataxia Telengiectasia
  • Breast cancer associated with BRCA2

Question 3

Question
All of the following are features of fanconi anemia except
Answer
  • Pancytopenia (bone marrow failure)
  • Risk of AML
  • Upper limb skeletal abnormalities
  • DNA repair defect
  • none of the above

Question 4

Question
Glioblastoma multiforme is due to 100x expression of an miRNA true or false?
Answer
  • True
  • False

Question 5

Question
Translocation in Burkitt's lymphoma
Answer
  • 8:14
  • 9:22
  • 11:22
  • none of the above

Question 6

Question
All of the following are true statements except
Answer
  • Kaposis sarcoma caused by HHV-8
  • Non-Hodgkin lymphoma - EBV
  • Cervical cancer - HPV
  • T-Cell leukemia - HTLV-I retrovirus
  • CML - HPV

Question 7

Question
HPV oncogenes E6 & E7 act by?
Answer
  • inactivating p53 thereby activating cell proliferation
  • activating P21 Transciption

Question 8

Question
In which cells telomeres are renewed (by activation of telomerase)?
Answer
  • Germ cells
  • cancer cells
  • all of the above
  • None of the above

Question 9

Question
Replicative senescence is due to the absence of telomerase - true or false
Answer
  • True
  • False

Question 10

Question
TERC : reverse transcriptase and TERT : RNA template true or false
Answer
  • True
  • False

Question 11

Question
Upregulation of what gene upregulates telomerase
Answer
  • MYC
  • ABL
  • BCR
  • RET

Question 12

Question
Telomerase reactivation in cancer is the initiating event true or false
Answer
  • True
  • False

Question 13

Question
Telomerase reactivation in cancer is an important step in cancer progression true or false
Answer
  • True
  • False

Question 14

Question
Which of the following receptors belong to RTK family (receptor tyrosine kinases)
Answer
  • GFR
  • Insulin receptor
  • both
  • none of the above

Question 15

Question
Activated RTKs phosphorylate what effector proteins?
Answer
  • PLC
  • PI3K
  • both PLC PI3K
  • Adenylate cyclase

Question 16

Question
RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false
Answer
  • True
  • False

Question 17

Question
Her2/EGFR2 genes are amplified in 30% breast cancers true or false
Answer
  • True
  • False

Question 18

Question
RAS-Gap gene codes for neurofibromin (NF1) true or false
Answer
  • True
  • False

Question 19

Question
Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false
Answer
  • True
  • False

Question 20

Question
Tamoxifen is an estrogen receptor antagonist true or false
Answer
  • True
  • False

Question 21

Question
Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false
Answer
  • True
  • False

Question 22

Question
Flutamide and bicalutamide are androgen receptor antagonists true or false
Answer
  • True
  • False
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