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Ass 1.3. Nan

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Assessment 1.3 Nan Days
shadow_spiers
Quiz by shadow_spiers, updated more than 1 year ago
shadow_spiers
Created by shadow_spiers over 9 years ago
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Question 1

Question
Which of the following is NOT an advantage of solution dosage form as compared to solid dosage form?
Answer
  • Greater Bioavailability
  • Ease of Transportation
  • Ease of Administration
  • Pediatric Use

Question 2

Question
Which of the following is true with regards to the solubility of a weak acid?
Answer
  • Solubility increases with decreasing pH
  • Solubility increases with increasing pH
  • Solubility decreases with increasing pH
  • Solubility remains constant with increasing pH

Question 3

Question
A novel compound dissolves in water and the solution becomes cold. Which of the following will further increase the solubility of this compound in water?
Answer
  • Decrease in temperature
  • Decreased amount of water
  • Increase in temperature
  • Increased amount of novel compound

Question 4

Question
__________ are dispersions of liquid drugs in liquid vehicles.
Answer
  • Suspension
  • Emulsion
  • Colloid
  • Gel

Question 5

Question
Which of the following has the least aqueous solubility
Answer
  • CHCl3
  • CCl4
  • CH2Cl2
  • CH3Cl

Question 6

Question
Syrup is a concentrated alcoholic solution with sweetener and medicinal agent ?
Answer
  • True
  • False

Question 7

Question
Which of the following is not an example of Cosolvent system?
Answer
  • Aromatic Elixir
  • Iodine Tincture
  • Acacia Syrup
  • Paregoric tincture

Question 8

Question
All of the following are advantages of Pharmaceutical solutions EXCEPT
Answer
  • Easier to swallow
  • Greater Bioavailability
  • More stable than solid dosage forms
  • Homogenous uniform dosing is possible

Question 9

Question
The two MAJOR factors affecting solubility are?
Answer
  • Temperature and agitation
  • pH and particle size
  • Polarity and agitation
  • Temperature and pH

Question 10

Question
To determine the ratio of buffer components to add to a solution to maintain a given pH you should use which equation?
Answer
  • pH= pKa + log (salt/acid)
  • pHmax = pKa + Log [(St-Sa)/Sa]
  • B= change in B/ change in pH
  • St= Sa(1+ [Ka/H])

Question 11

Question
All of the following are generally true about Organic Compound Solubility EXCEPT:
Answer
  • More carbon atoms decrease the aqueous solubility
  • Halogens decrease solubility
  • Polar groups increase solubility
  • Low melting point indicates low solubility

Question 12

Question
Which of the following would be considered an ethanol/ water cosolvent system.
Answer
  • Inverted syrup
  • Magic Mouthwash
  • Paregoric
  • Acacia Syrup

Question 13

Question
Which of the following is an example of a cosolvent?
Answer
  • Sodium Acetate
  • Oleic Acid
  • Sodium Benzoate
  • Saccharin Sodium

Question 14

Question
which of the following is NOT a force of attraction that affects dissolution?
Answer
  • Ion-dipole
  • Van Der Waals
  • Hydrogen Bonding
  • Ionic Bonding

Question 15

Question
Sedimentation increases with_______?
Answer
  • Particle size reduction
  • Increase in viscosity of dispersion medium
  • Increase in density of dispersed phase
  • Increase in density of dispersion medium

Question 16

Question
Which of the following is true when particle aize of an antibiotic powder is reduced from 50 micrometers to 5 micrometers?
Answer
  • Higher surface area, Lower surface energy
  • Lower surface area,Higher surface energy
  • Lower surface area, Lower surface energy
  • Higher surface area, higher surface energy

Question 17

Question
Flocculation occurs due to stronger forces of attraction between the particles of a suspension.
Answer
  • True
  • False

Question 18

Question
The Sedimentation Volume (F) for an ideal flocculated system is
Answer
  • 0.5
  • 1.0
  • 0.7
  • 0.3

Question 19

Question
Which of the following is responsible for charge on a neutral particle surface when suspended in water?
Answer
  • Adsorption of OH-
  • Adsorption of H2O
  • Particle wetting
  • Particle agglomeration

Question 20

Question
In an electrical double layer which layer is associated with the zeta potential?
Answer
  • Bulk layer
  • Diffuse layer
  • Surface layer
  • Stern layer

Question 21

Question
Which of the following situations best represents a deflocculated system?
Answer
  • F=0.2
  • F=0.9
  • F=1.0
  • F=1.2

Question 22

Question
Flocculation is observed at extreme (+)ve and (-)ve values of zeta potential.
Answer
  • True
  • False

Question 23

Question
The structured vehicle approach is applicable to both flocculated and deflocculated particles.
Answer
  • True
  • False

Question 24

Question
Which of the following best represents the flow of flocculated suspension?
Answer
  • Newtonian Flow
  • Dilant Flow
  • Plastic Flow
  • Pseudoplastic Flow

Question 25

Question
In which of the following methods oil and emulsifier are mixed first followed by addition of water at once?
Answer
  • In-situ soap method
  • English Method
  • Auxiliary Method
  • Continental Method
  • Bottle Method

Question 26

Question
Skin permeation is a must for the component(s) of both medicated and non-medicated topical dosage forms.
Answer
  • True
  • False

Question 27

Question
A major skin permeation pathway for small hydrophilic molecule is?
Answer
  • Trans appendageal
  • Hair Follices
  • Transcellular
  • Intercellular

Question 28

Question
Absorption bases are associated with all of the following except?
Answer
  • Anhydrous
  • Absorb water
  • Water Washable
  • Hydrous
  • Occlusive

Question 29

Question
What is HFA?
Answer
  • Hydroflouroalkane
  • Hydroflorine Association
  • How Far Away
  • Happy Friend Association

Question 30

Question
Droplets decelerate as they leave the spray nozzle of a pressurized spray.
Answer
  • True
  • False

Question 31

Question
pDMIs can be sprayed in any orientation
Answer
  • True
  • False

Question 32

Question
All medical Aerosol products contain a propellant
Answer
  • True
  • False

Question 33

Question
All nasal sprays deliver the same dose independent of the orientation in which they are used
Answer
  • True
  • False

Question 34

Question
Which of the following is NOT an advantage of a topical antibiotic sprayed on the skin rather than delivered by a cream.
Answer
  • Convenient
  • Minimal contamination of unused product
  • Accurate dose metering
  • No need to touch skin
  • Smaller particle size

Question 35

Question
If inhaled, particles with a diameter of 6 micrometers would be expected to penetrate the respiratory system to the level of the:
Answer
  • Bronchioles
  • Alveoli
  • Nasal Cavity
  • Throat (pharynx)

Question 36

Question
For which type(s) of aerosol system(s) will the pressure drop as the product is used?
Answer
  • Compressed gas system
  • Three- phase system
  • Two-Phase system
  • B and C only

Question 37

Question
Which part of the valve assembly of an aerosol is responsible for preventing leakage of the formulation from the container?
Answer
  • Mounting Cap
  • Actuator
  • Gasket
  • Housing

Question 38

Question
Which of the following is NOT an example of a "surface Spray" aerosol?
Answer
  • Dermatological aerosols
  • Paint Sprays
  • Hair Sprays
  • Room deodorizers

Question 39

Question
What is the FDA recommended alcohol content limit in liquid OTC drug product for children 6-12 years?
Answer
  • 10%
  • 1%
  • 0.5%
  • 5%

Question 40

Question
Which of the following descriptive terms of relative solubility includes 12.5% w/v strength?
Answer
  • Very soluble
  • Soluble
  • Slightly soluble
  • Freely Soluble

Question 41

Question
Which of the following groups on organic molecules will NOT increase water solubility?
Answer
  • CH2F
  • NH2
  • COOH
  • SO3H

Question 42

Question
Which of the following is the pharmaceutical advantage of elixirs over syrups as liquid dosage forms?
Answer
  • Contains less sugar
  • Dissolve ionized and unionized drugs
  • Provide faster drug absorption
  • Are better at masking the taste of drugs

Question 43

Question
Which of the following minimum alcohol percentages is required in medicated syrups to prevent microbial growth?
Answer
  • 5%
  • 0.1%
  • 15%
  • 1%

Question 44

Question
Water cannot dissolve which of the following organic compounds by intermolecular hydrogen bonds?
Answer
  • Esters
  • Alcohol
  • Acids
  • Hydrocarbons

Question 45

Question
Besides accurately and conveniently measuring dosage volume which of the following factors is important when making drug solutions for oral administration?
Answer
  • Color
  • Bioavailability
  • Stability
  • Taste

Question 46

Question
Which of the following is an example of an ingredient in an organogel?
Answer
  • Sodium alginate
  • Hydrocarbon waxes
  • Polyethylene glycol
  • Carboxylmethylcellulose

Question 47

Question
Which of the following describes the action of a flocculating agent in drug suspensions?
Answer
  • Enable loose interparticle attraction
  • Dissolve the suspended particles
  • Prevent interparticle attraction
  • Reduce the particle size

Question 48

Question
Which of the following is a correct statement regarding inhalation drug products (aerosols)?
Answer
  • Each successive dose is slightly smaller as the pressure decreases with each actuation.
  • The total quantity of accurate dose from a metered dose inhaler is limited by depletion of the liquid phase of the propellant
  • The total quantity of accurate doses from a metered dose inhaler is limited by depletion of the active drug.
  • chlorofluorocarbon are federally prohibited for use as propellants

Question 49

Question
Which of the following blends of surfactants would favor a stable O/W emulsion?
Answer
  • 0.5 parts Myrj 45 + 0.5 parts Brij 30
  • 0.4 parts Span40 +0.6 parts Tween 20
  • 0.6 parts span60 +0.4 parts Tween80
  • 0.7 parts span80 + 0.3 parts Tween60

Question 50

Question
Which of the following terms describes a fluid drug preparation that would increasingly flow more freely as it is agitated?
Answer
  • Pseudoplastic
  • Plastic
  • Dilant
  • Thixotropic

Question 51

Question
Stoke's Law equation does NOT include which of the following factors?
Answer
  • Interparticle Attraction
  • Fluid Density
  • Particle Diameter
  • Gravitational Constant

Question 52

Question
When treating a topical condition, all of the following are suitable criteria for selecting an ointment base for drug delivery EXCEPT:
Answer
  • Degree of Occlusion provided
  • Therapeutic systemic blood levels of drug
  • Stability of drug in an ointment base
  • Characteristics of the skin that will be treated.

Question 53

Question
Which of the following is an example of a water soluble base
Answer
  • White ointment USP
  • Lanolin USP
  • Polyehtylene Glycol Ointment USP
  • Hydrophillic Ointment USP

Question 54

Question
Which of the following is NOT an appropriate pharmacist counseling point to a patient before applying ophthalmic ointment?
Answer
  • Tip of the tube should be placed in gentle contact with the conjunctival sac
  • Patient should wash and dry hands before application
  • Improperly handled ophthalmic products can lead to eye infection
  • After application blurred vision is normal and will likely occur

Question 55

Question
Which of the following is FALSE regarding levigating agents which are used to reduce drug particle size?
Answer
  • Glycerin is an appropriate levigating agent for O/W bases
  • The levigating agent must be physically and chemically compatible with the drug and the ointment base
  • The drug for levigation should be soluble in the liquid used as the levegating agent
  • Mineral oil is a good levigating agent for W/O ointment bases

Question 56

Question
Which of the following TDDS products is permitted to be cut into smaller pieces for patient specific therapy?
Answer
  • Nitro-Dur
  • Nicoderm
  • Duragesic
  • Fentanyl Patch
  • All of the above
  • None of the above

Question 57

Question
All of the following factors predict favorable transdermal drug absorption for systemic therapy EXCEPT:
Answer
  • Full hydration of stratum corneum
  • A high aqueous solubility of the drug
  • Molecular weight of drug of about 100-400
  • A high partition coefficient of the drug

Question 58

Question
Wearing a TDDS for longer than the approved duration can result in unsafe plasma drug concentration
Answer
  • True
  • False
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