34371671
Description
Quiz by ACAPUN INSTITUTE, updated more than 1 year ago
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Created by ACAPUN INSTITUTE
almost 3 years ago
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Question 1
Question
The therapeutic effect of the salicylates is explained on the basis of the ability of the drug to
Answer
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A) Activate autonomic reflexes
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B) Uncouple oxidative phosphorylation
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C) Inhibit the synthesis of prostaglandins
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D) Competitively antagonize prostaglandins at the receptor site
Question 2
Question
The mechanism of the antipyretic action of salicylates probably results from
Answer
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A) Inhibition of prostaglandin synthesis in the CNS affecting hypothalamic temperature regulation
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B) Inhibition of bradykinin in the periphery leading to sweating
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C) Depression of oxidative enzymes leading to decreased heat production
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D) Suppression of cholinergic mediators in the hypothalamus
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E) Stimulation of norepinephrine in the hypothalamus
Question 3
Question
The antipyretic action of salicylates is explained in part by
Answer
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A) Analgesia leading to sedation
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B) Increased blood flow through the hypothalamus
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C) Cutaneous vasodilation leading to increased heat loss
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D) Depression of oxidative processes leading to decreased heat production
Question 4
Question
The locus of action of aspirin’s central antipyretic effect is the
Answer
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a. Brain stem
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b. Hypothalamus
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c. Basal ganglia
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d. Limbic system
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e. Cerebral cortex
Question 5
Question
A patient who has been taking large quantities of aspirin might show increased postoperative bleeding because aspirin inhibits
Answer
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a. Synthesis of thromboxane A2 and prevents platelet aggregation
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b. Synthesis of prostacyclin and prevents platelet aggregation
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c. Synthesis of prostaglandin and prevents production of blood platelets
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d. Thrombin and prevents formation of the fibrin network
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e. G.I. absorption of vitamin K and prevents synthesis of blood clotting factors
Question 6
Question
Anti-inflammatory agents, such as aspirin, interfere with hemostasis by
Answer
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a. Activating antithrombin
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b. Preventing vasoconstriction
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c. Inhibiting thrombin generation
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d. Inhibiting platelet aggregation
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e. Inhibiting polymerization of fibrin
Question 7
Question
Which of the following anti-inflammatory agents does NOT act primarily by inhibiting activity of prostaglandin synthetase?
Answer
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a. Diflunisal
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b. Ibuprofen
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c. Triamcinolone
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d. Oxyphenbutazone
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e. Acetylsalicylic acid
Question 8
Question
A nonsteroidal, anti-inflammatory agent that appears to produce fewer gastrointestinal disturbances than high does of aspirin is
Answer
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a. Ibuprofen
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b. Probenecid
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c. Pentazocine
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d. Acetaminophen
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e. Phenylbutazone
Question 9
Question
Prolonged use of which of the following drugs does NOT cause a predisposition to gastric irritation and bleeding?
Answer
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a. Phenytoin
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b. Ibuprofen
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c. Indomethacin
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d. Phenylbutazone
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e. Acetylsalicylic acid
Question 10
Question
Each of the following agents has been associated with gastric irritation EXCEPT
Answer
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a. Aspirin
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b. Alcohol
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c. Ibuprofen
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d. Indomethacin
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e. Acetaminophen
Question 11
Question
Which of the following is NOT produced by excessive doses of acetylsalicylic acid?
Answer
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a. Delirium
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b. Tinnitus
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c. Hypothermia
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d. Hyperventilation
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e. Metabolic acidosis
Question 12
Question
All of the following are pharmacologic and toxicologic properties of aspirin EXCEPT
Answer
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a. Tinnitus
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b. Analgesia
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c. Salicylism
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d. Antipyresis
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e. Suppression of the immune response
Question 13
Question
Therapeutic effects of aspirin include
a. Analgesia
b. Tranquilization
c. Pyretic action
d. Anti-inflammatory action
e. Antirheumatic action
Answer
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A) (a), (b) and (c)
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B) (a), (c) and (d)
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C) (a), (d) and (e)
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D) (b), (c) and (d)
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E) (b), (d) and (e)
Question 14
Question
All of the following are pharmacologic or toxicologic properties of acetylsalicylic acid EXCEPT
Answer
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a. Tinnitus
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b. Analgesia
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c. Antipyresis
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d. Methemoglobinemia
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e. Inhibition of prostaglandin synthesis
Question 15
Question
All of the following are possible effects of aspirin EXCEPT
Answer
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a. Reduction of fever
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b. Shortening of bleeding time
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c. Suppression of inflammatory response
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d. Bleeding from the gastronintestinal tract
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e. Increase in the renal excretion of uric acid at high doses
Question 16
Question
Of the following, aspirin does NOT cause
Answer
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a. Occult bleeding
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b. Nausea and vomiting
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c. Acid-base disturbance
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d. Suppression of the cough reflex
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e. Decreased tubular reabsorption of uric acid
Question 17
Question
Which of the following is NOT true regarding acetaminophen?
Answer
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a. It has antipyretic properties
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b. It may induce methemoglobinemia
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c. It can be combined with codeine
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d. It has anti-inflammatory properties
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e. It is not cross-allergenic with aspirin
Question 18
Question
The most prominent acute toxic effect associated with acetaminophen use is
Answer
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a. Hemorrhage
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b. Renal necrosis
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c. Hepatic necrosis
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d. Gastric ulceration
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e. Respiratory alkalosis
Question 19
Question
Which of the following anti-inflammatory agents does NOT act primarily by inhibiting the activity of cyclooxygenase?
Answer
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a. Ibuprofen
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b. Diflunisal
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c. Prednisone
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d. Indomethacin
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e. Phenylbutazone
Question 20
Question
Which of the following is the most appropriate drug to use to lower fever in a child under 12?
Answer
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a. Aspirin
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b. Ibuprofen
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c. Acetaminophen
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d. Salicylate
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e. Diflunisal
Question 21
Question
Which analgesic from the following list has the longest half-life?
Answer
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a. Acetaminophen
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b. Aspirin
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c. Diflunisal (Dolobid)
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d. Ibuprofen
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