34387436
Description
Quiz by ACAPUN INSTITUTE, updated more than 1 year ago
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Created by ACAPUN INSTITUTE
about 3 years ago
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Question 1
Question
A pharmacologic agonist is a chemical substance that
Answer
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a. Binds to a specific receptor and produces a response
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b. Elicits a pharmacologic response without binding to a receptor
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c. Possesses the property of affinity but not of intrinsic activity
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d. Exhibits no activity except to oppose the effect of an antagonist
Question 2
Question
When comparing drugs with respect to intensity of response, the drug that produces the greatest maximum effect is the one with the highest
Answer
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a. Affinity
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b. Potency
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c. Efficacy
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d. Therapeutic index
Question 3
Question
If drug has a greater efficacy than drug B, then drug A
Answer
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a. Is more toxic than drug B
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b. Has a greater affinity for the receptor than drug B
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c. Has a greater margin of safety than drug B
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d. Is capable of producing a greater maximum effect than drug B
Question 4
Question
A drug with a high LD50 and a low ED50 has a
Answer
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a. High therapeutic index and is, therefore, very dangerous
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b. High therapeutic index and is, therefore, relatively safe
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c. Low therapeutic index and is, therefore, very dangerous
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d. Low therapeutic index and is, therefore, relatively safe
Question 5
Question
The ratio of the median lethal dose (LD50) to the median effective dose (ED50) is the
Answer
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a. Morbidity index
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b. Mortality index
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c. Anesthetic ratio
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d. Therapeutic index
Question 6
Question
The therapeutic index of a drug is the ratio of
Answer
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a. The effective dose to the toxic dose
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b. Half the toxic dose to half the effective dose
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c. The maximum tolerated dose to the minimum effective dose
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d. The lethal dose for 50% of animals to the effective dose for 50% of animals
Question 7
Question
The phenomenon in which two drugs produce opposite effects on a physiologic system but do not act at the same receptor site is
Answer
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a. Potentiation
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b. Chemical Antagonism
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c. Competitive antagonism
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d. Physiologic antagonism
Question 8
Question
Epinephrine antagonizes the effects of histamine by
Answer
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a. Preventing the release of histamine
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b. Acting on the central nervous system
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c. Producing physiologic actions opposite to that of histamine
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d. Competitively blocking histamine at the cellular receptor site
Question 9
Question
Interaction between nitroglycerin and epinephrine is what type of antagonism?
Answer
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a. Allosteric
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b. Physiologic
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c. Biochemical
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d. Competitive
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e. Pharmacologic
Question 10
Question
When the combined action of two drugs is greater than the sum of their individual actions, this is
Answer
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a. Induction
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b. Synergism
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c. Idiosyncrasy
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d. Hypersensitivity
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e. Cumulative action
Question 11
Question
Which of the following responses is least predictable in occurrence?
Answer
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a. Toxicity
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b. Side-effects
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c. Idiosyncrasy
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d. Tachyphylaxis
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e. Therapeutic effects
Question 12
Question
Idiosyncrasies to drugs are related to
Answer
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a. Species
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b. Genetic factors
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c. Age of the patient
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d. All of the above
Question 13
Question
Two drugs, A and B, have the same mechanism of action. Drug A in a dose of 5 mg. produces the same magnitude of response as drug B in a dose of 500 mg. Which of the following statements is correct?
Answer
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a. Drug A is less toxic
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b. Drug A is more efficacious
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c. Drug A is 100 times as potent
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d. Drug A has a shorter duration of action
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e. Drug A is a better drug to use when a maximal response is desired
Question 14
Question
According to the theory that agonists and antagonists occupy the same receptor site, an effective antagonist should exhibit
Answer
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a. High intrinsic activity and high affinity
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b. Low intrinsic activity and low affinity
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c. High intrinsic activity and low affinity
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d. No intrinsic activity and high affinity
Question 15
Question
All of the following statements are true regarding the occupation theory of drug-receptor interaction EXCEPT:
Answer
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a. The affinity of a drug is dependent on its intrinsic activity
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b. The maximum effect of a drug occurs when all receptors are occupied
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c. An antagonist has affinity for the receptor but not intrinsic activity
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d. The magnitude of the effect of a drug is proportional to the number of receptors occupied
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e. It follows the law of mass action
Question 16
Question
The occupational theory of drug-receptor interaction states that
a. The magnitude of the drug response is proportional to the number of receptors occupied
b. A partial agonist has intrinsic activity but no affinity for the receptor site
c. An antagonist drug has affinity but no intrinsic activity
d. The rate at which the drug-receptor complex associates and dissociates determines drug efficacy
e. The degree of drug action is dependent on the law of mass action
Answer
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a) (a), (b) and (c)
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b) (a), (c) and (e)
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c) (b), (c) and (d)
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d) (b) and (e)
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e) (c), (d) and (e)
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