Question 1
Question
The Na/K transporter (pump) is blocked by:
Answer
-
TTX
-
local anesthetics
-
TEA
-
none of the above
-
all of the above
Question 2
Question
nAChR channels at the endplate:
Answer
-
open when the endplate is depolarized
-
are non-selective in that they allow positive and negative ions to pass through
-
ions pass through them by simple diffusion
-
open when serotonin or glutamate is present
-
none of the above
Question 3
Question
Axons X and Y are myelinated and of equal diameter, suppose that, in X the internodal distance is 10 nm while in Y the internodal distance is 20 nm. Based on this information:
Answer
-
axon X is faster conducting than Y
-
axon Y is faster conducting than X
-
axons X and Y have equal conduction velocity
-
axon X save more energy than axon Y
-
axons X and Y save same amount of energy
Question 4
Question
As a result of repetitive activity the K concentration immediately outside the nerve terminal rises to 10 meq whereas the K concentration inside decreases to 100 meq. Thus: (hint: log 10=1)
Answer
-
a type of presynaptic inhibition results
-
the nerve terminal is depolarized
-
the incoming action potential is decreased in amplitude
-
the amount of transmitter released is less
-
All of the above
Question 5
Question
The fate of Na and K ions that enter and leave respectively during the action potential:
Answer
-
Na ions exit through their channels just before they close
-
K ions enter through the delayed rectifier channels before they close
-
the Na/K pump returns the ions to their original concentrations
-
Na ions are trapped, but they slowly diffuse out across the membrane.
-
all of the above
Question 6
Question
Which of the following statements is/are incorrect:
Answer
-
alkalosis can cause excitation of the CNS
-
termination of epileptic seizures can be due to Wedensky inhibition
-
in the Renshaw circuit activity of one motor neuron result in self-inhibition as well as inhibition of an antagonist second motor neuron
-
removal of Ca from the vicinity of a synapse causes increased excitability of the axon but also causes inhibition of synaptic transmission
-
none of the above
Question 7
Question
Which of the following statements is/are incorrect:
Answer
-
the motor endplate is electrically not excitable
-
pinocytosis is the reverse of phagocytosis
-
demarcation (injury) potential is a monophasic action potential
-
water is a polar molecule but can cross the cell membrane freely
-
all of the above
Question 8
Question
If the voltage-regulated sodium channels failed to become inactivated, then the duration of action potential
Question 9
Question
What would happen to a muscle action potential if 50% of the sodium channels are blocked?
Answer
-
it would be similar to a pacemaker action potential
-
it would be similar to a heart ventricular muscle action potential
-
it would be the same but with no relative refractory period
-
it would be the same but with no absolute refractory period
-
it would be of much smaller amplitude
Question 10
Question
Postsynaptic density (opacity) is due to the presence of ______ in the membrane:
Answer
-
mitochondria
-
myelin
-
receptors
-
synaptic vesicles
-
all of the above
Question 11
Question
Multiple sclerosis (MS):
Answer
-
lesions are more diffused than they are in ALS
-
occurs both in the CNS and the PNS
-
is commonly known as Lou Gehrig’s disease
-
occurs in the PNS only
-
none of the above
Question 12
Question
The resting membrane potential of a nerve is:
Answer
-
less negative when Na+ concentration in extracellular fluid [Na]o is decreased
-
more negative when [K+]o is increased
-
more negative when [Na+]o is increased
-
more negative when [Ca2+]o is increased
-
none of the above
Question 13
Question
Which of the following statement(s) is/are True?
Answer
-
Compound action potentials are seen only when a nerve bundle containing a large number of axons of different conduction velocities is stimulated
-
Extracellular fluid contains more Ca2+ than intracellular fluid
-
Transfer of electrical signal across synapses is called transmission, whereas
travel of signal along axons is called conduction
-
specific Na+ channels are not the same as acetylcholine channels.
-
all of the above
Question 14
Question
The inhibitory postsynaptic potential (IPSP):
Answer
-
is the result of positive ions moving through ligand-gated channels
-
has a brief refractory period
-
is propagated
-
is the cause of stimulus artifact
-
none of the above
Question 15
Question
The refractory periods (RP):
Answer
-
the absolute RP is due to complete closure and inactivation of Na channels
-
are due to opening of the delayed rectifier
-
can be seen in nerve action potentials but not in muscle action potentials
-
choices 1 & 2
-
choices 2 & 3
Question 16
Question
Long-term potentiation (LTP)
Answer
-
is a form of structural synaptic plasticity
-
is manifested as an increase in synaptic strength (i.e. increased EPSP)
-
is same a perforated synapses
-
choices 1 & 2
-
choices 1, 2 & 3
Question 17
Question
Depolarization of the terminal button leads to release of neurotransmitter in the following way:
Answer
-
neurotransmitter in the neuroplasm diffuses across the terminal membrane through the synaptic cleft and onto the postsynaptic membrane.
-
the vesicles are released into the synaptic cleft where they diffuse and fuse into the postsynaptic membrane.
-
neurotransmitter diffuses through gap junction from the presynaptic to postsynaptic membrane
-
none of the above
Question 18
Question
Presynaptic inhibition:
Question 19
Question
While studying the transport of molecule B across the cell membrane, you discover that as you increase the concentration of B in the extracellular fluid, the rate of transport also initially increases. If the concentration of extracellular B is further increased, the rate becomes constant. Based on this information, which of the following statements best describe this situation?
Answer
-
molecule B is transported from outside to the cytoplasm.
-
the transport process involves a carrier protein.
-
the system exhibits saturation.
-
choices 1 & 2
-
choices 1, 2 & 3
Question 20
Question
A man falls into deep sleep with one arm under his head. This arm is paralyzed when he awakens, but it tingles, and he can feel pain sensation in it. The reason for the loss of motor function without loss of pain sensation is that:
Answer
-
A fibers are more susceptible to hypoxia than B fibers
-
A fibers are more susceptible to pressure than B fibers
-
A fibers are more susceptible to hypoxia than C fibers
-
A fibers are more susceptible to pressure than C fibers
Question 21
Question
Which of the following statement(s) is/are False?
Answer
-
compound action potential is seen when a single axon is stimulated
-
Schwann cells provide myelin for CNS nerve axons
-
a compound action potential is an all-or-none phenomenon
-
choices 1 and 2
-
choices 1, 2 and 3
Question 22
Question
When an action potential depolarizes a terminal button, Ca2+:
Answer
-
enters the synaptic vesicles
-
is released into the synaptic cleft
-
enters the terminal button
-
enters the postsynaptic membrane to generate an EPSP
-
generates the coated vesicles
Question 23
Question
Presynaptic facilitation (i.e. increased transmitter release) occurs when:
Answer
-
extracellular concentration of sodium increases
-
extracellular concentration of potassium increases
-
calcium channels in the presynaptic membrane are inhibited
-
calcium channels in the presynaptic membrane remain open longer
-
temporal summation occurs
Question 24
Answer
-
occurs only in A type nerve axon
-
of the dendrites (unlike axons) continues uninterrupted (no nodes of Ranvier)
-
action potentials occur at the nodes of Ranvier along the axon
-
choices 1 and 3
-
choices 2 and 3
Question 25
Question
In the CNS, a severed or injured axon undergoes Wallerian degeneration but virtually no regeneration takes place because:
Answer
-
astrocytes produce certain chemicals that prevent regeneration
-
astrocytes produce scar tissue to block regeneration
-
there are no glial cells to lay the track for a growing axon
-
choices 1 and 2
-
choices 1, 2 and 3
Question 26
Question
Which of the following comparisons between neurons and muscle tissue is incorrect?
Answer
-
resting potentials are greater in muscle fibers
-
muscle fibers conduct action potentials at relatively slower speeds
-
action potentials last longer in muscle fibers
-
muscle fibers conduct action potentials only by saltatory conduction
Question 27
Question
How would the ventricular muscle action potential be affected if calcium channels were blocked?
Answer
-
it would look like a pacemaker action potential
-
it would look like a nerve action potential
-
it would be the same
-
it would be the same but with no absolute refractory period
-
none of the above
Question 28
Question
The generation of an action potential occurs when the following the main steps take place:
a. sodium channels are inactivated
b. voltage-regulated potassium channels open and potassium moves out of the
cell initiating repolarization
c. sodium channels regain their normal properties
d. a graded depolarization brings an area of an excitable membrane to threshold
e. a temporary hyperpolarization occurs
f. sodium channel activation occurs
g. sodium ions enter the cell and depolarization occurs,
the proper sequence of event is:
Answer
-
d, f, g, c, b, e, a
-
d, f, g, a, b, c, e
-
f, g, d, a, b, c, e
-
b, d, f, g, a, c, e
-
d, b, e, f, g, c, a
Question 29
Question
Lysosomes are stabilized by:
Answer
-
asbestos
-
endomethacin
-
high vitamin A intake
-
choices 1 & 2
-
choices 2 & 3
Question 30
Question
Action potential is recorded from a length of squid axon that has a conduction velocity of 100 m/sec; the latent period is 1 msec and the amplitude of the action potential is 100mV. With this information in hand the length of the axon must be:
Question 31
Question
synaptic transmission decreases when:
Answer
-
a calcium ion chelating agent is present
-
postsynaptic receptors are blocked
-
the RMP of the presynaptic terminal is slightly (e.g. 3-5 mV) more negative
-
choices 1 & 2
-
choices 2 & 3
Question 32
Question
About Receptors:
Answer
-
ionotropic receptors exist only on postsynaptic membrane
-
metabotropic receptors exist only on presynaptic membrane
-
metabotropic receptors, which are G-protein coupled, exist on postsynaptic membrane of fast synapses
-
ionotropic receptors, which are not G-protein coupled, exist on postsynaptic membrane of fast synapses
-
none of the above
Question 33
Question
The All-or-nothing rule applies to:
Answer
-
IPSP
-
mEPP
-
EPSP
-
EPP
-
none of the above
Question 34
Answer
-
result in local depolarizations
-
result in local hyperpolarizations
-
increase membrane permeability to sodium ions
-
prevent the efflux of potassium ions
-
prevent the efflux of calcium ions
Question 35
Question
When a second EPSP arrives at a single synapse before the effects of the first have disappeared, what occurs is:
Question 36
Question
Exocytosis is involved in:
Question 37
Question
Which of the following is not normally embedded in the plasma membrane?
Answer
-
neurotransmitter receptors e.g. ACh receptors
-
K+ channels
-
Glucose transporters in insulin-sensitive cells.
-
Microtubules transporting synaptic vesicles
-
the Na-K pump
Question 38
Question
The resting potential is due, in part, to the:
Answer
-
insulating effect of the Schwann cell
-
large negatively charged proteins on the outside
-
activity of the Na-K pump
-
Na+ equilibrium potential
-
Ca2+ equilibrium potential
Question 39
Question
Threshold for an action potential:
Answer
-
is the same for different nerves
-
is a measure of conduction velocity of the nerve
-
the higher it is the more excitable the nerve is.
-
is dependent on the number of Na channels in the nerve; the higher the
number the lower the threshold.
-
All of the above.
Question 40
Question
The amplitude of action potential in an axon is dependent on:
Answer
-
extracellular Na+
-
extracellular K+
-
intracellular Ca2+
-
extracellular Cl-
-
none of the above