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CMB2001 Quiz

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lectures 1-4
Phil Oklam
Quiz by Phil Oklam, updated more than 1 year ago
Phil Oklam
Created by Phil Oklam about 9 years ago
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Resource summary

Question 1

Question
Where is the TATA box?
Answer
  • -31 to -26
  • -32 to -37
  • -2 to +4
  • +28 to +32

Question 2

Question
Where is Inr?
Answer
  • -2 to +4
  • -37 to -32
  • -31 to -26
  • +28 to +32

Question 3

Question
Where is DPE?
Answer
  • +28 to +32
  • -2 to +4
  • -37 to -32
  • -31 to -26

Question 4

Question
Where is BRE?
Answer
  • -37 to -32
  • -31 to -26
  • -2 to +4
  • +28 to +32

Question 5

Question
Which are true of CpG Islands?
Answer
  • rich in CG sequences
  • TXN occurs at a lower rate and at several start sites
  • C residues escape methylation
  • Methylation is associated with silencing of the gene
  • Extensively phosphorylated at CTD
  • Form a complex on TATA box to recruit RNA Pol II to the promoter

Question 6

Question
Which of the following are associated with RNA Pol II?
Answer
  • tRNA
  • snRNA
  • mRNA
  • miRNA
  • rRNA

Question 7

Question
Which RNA Polymerase is found in the nucleolus?
Answer
  • RNA Pol I
  • RNA Pol II
  • RNA Pol III

Question 8

Question
Which of the following is the correct sequence for the formation of PIC?
Answer
  • DABPolFEH
  • DBAPolFEH
  • DABPolEFH
  • DAPolEBFH

Question 9

Question
Which GTF interacts with RNA Pol II during formation of PIC?
Answer
  • TFIIB
  • TFIID
  • TFIIA
  • TFIIE
  • TFIIH
  • TFIIF

Question 10

Question
What happens to RNA Pol II as it transcribes along RNA?
Answer
  • Phosphorylated at CTD
  • Methylated at CTD
  • Acetylated at CTD
  • Phosphorylated at N terminal tail
  • Acetylatetd at N terminal tail

Question 11

Question
Which of the following are true of TFIIH?
Answer
  • It binds over Inr
  • It binds over TATA
  • It requires ATP to separate template strand
  • It requires NAD to separate template strand
  • It is released as RNA Pol II moves
  • It stays bound as RNA Pol II moves
  • Its CAK subunit contains kinase for phosphorylation
  • Its Core subunit contains kinase for phosphorylation
  • It contains helicases XPB and XPD
  • It contains helicases XPC and XPB

Question 12

Question
Which of the following is a trilobular structure containing TBP and TAFs?
Answer
  • TFIID
  • TFIIH
  • TFIIE
  • TFIIA
  • TFIIB
  • RNA Pol II

Question 13

Question
TBP directs assembly of PIC on the TATA complex and only requires TAFs to do so in a TATA-less promoter
Answer
  • True
  • False

Question 14

Question
Which of the following are UAS common sequence elements?
Answer
  • GC box
  • Octamer
  • CAAT box
  • HSE
  • SRE
  • BRE
  • DPE

Question 15

Question
What are leucine zippers, zinc fingers, homeodomains and helix loop helixes all examples of?
Answer
  • DNA binding domains
  • Activation domains
  • Enhancer elements
  • GTFs

Question 16

Question
Which of the following are true of Activation domains in activators?
Answer
  • They have a lack of sequence conservation
  • They are generally unstructured
  • They contain multiple short segments working together in an additive fashion
  • They can be gln rich, proline rich or acidic patches

Question 17

Question
How do activators work?
Answer
  • Promote binding of other activators
  • Stimulate complex assembly (Recruitment)
  • Release stalled RNA Pol II
  • Modulation of chromatin

Question 18

Question
Which of the following are true of Mediator?
Answer
  • 22 polypeptide complex
  • Comprised of a head, middle and tail
  • Associates with RNA Pol through CTD
  • Enhances PIC formation
  • Forms a bridge between RNA Pol II and activators

Question 19

Question
Which of the following is not a core histone?
Answer
  • H1
  • H3
  • H4
  • H2A
  • H2B

Question 20

Question
N terminal tails of histones are highly acidic
Answer
  • True
  • False

Question 21

Question
What do nucleosomes consists of?
Answer
  • 2 x H2A-H2B dimers
  • H2A-H2B tetramer
  • H1 linker histones
  • H3-H4 tetramer
  • 2 x H3-H4 dimers
  • 147 bp DNA wrapped around the octamer
  • 471 bp DNA wrapped around the octamer

Question 22

Question
Mitotic chromosomes are condensed, interphase chromosomes occupy a distinct territory in the nucleus and are decondensed to about 100-400nm fibres
Answer
  • True
  • False

Question 23

Question
Which of the following switches off the Gal4 promoter?
Answer
  • Galactose
  • Glucose

Question 24

Question
Which of the following are methods of remodelling chromatin?
Answer
  • Histone variants
  • ATP dependent chromatin remodelling
  • Post translational modifications

Question 25

Question
Which histone does not express variants?
Answer
  • H4
  • H3
  • H1
  • H2A
  • H2B

Question 26

Question
Where do post translational modifications of histones occur?
Answer
  • N-terminal tail
  • Histone variants
  • C Terminal domain
  • DPD
  • TBP

Question 27

Question
The GNAT and MYST family are which enzymes?
Answer
  • HATs
  • HDACs
  • HKMTs
  • SWI/SNF ATPase

Question 28

Question
Histone methylation is readily reversible and has no affect on charge
Answer
  • True
  • False

Question 29

Question
Specific methylated lysines are recognised by specific proteins, which of the following are markers for repression?
Answer
  • H3 Lys 9
  • H3 Lys 27
  • H3 Lys 4
  • H3 Lys 36

Question 30

Question
Which of the following are SWI2/SNF2 ATPase subfamilies?
Answer
  • SWI2/SNF2
  • ISWI
  • CHD/Mi2
  • Ino80

Question 31

Question
What is the deletion of SWI/SNF associated with?
Answer
  • Tumours
  • Tumour suppression

Question 32

Question
Which class of HDACs is not zinc dependent?
Answer
  • Class III
  • Class I
  • Class II
  • Class IV

Question 33

Question
Regions of DNA that are hypoacetylated by HDACs are what?
Answer
  • Repressed
  • Activated

Question 34

Question
Which of the following is an example of an ATP dependent remodeller that commonly mediates repression?
Answer
  • NuRD
  • SWI/SNF
  • Ume3
  • Rpd3
  • Sin3
  • HP1

Question 35

Question
What is the name of the enzyme that methylates H3K9?
Answer
  • Suvar39
  • HP1
  • NuRD
  • Sin3
  • Ume6

Question 36

Question
Is Tsix or Xist on the antisense strand of DNA?
Answer
  • Tsix
  • Xist

Question 37

Question
What is the Role of NF-KB family of transcription factors?
Answer
  • Regulating inflammation, DNA damage, cell death, cell adhesion and proliferation.
  • The guardian of the genome.

Question 38

Question
NF-KB is pre-synthesised and retained within the cytoplasm in an active form bound to inhibitor protein IxB
Answer
  • True
  • False

Question 39

Question
Cellular [blank_start]stimulation[blank_end] > IkB phosphorylated > ubiquitination by E3 Ubiquitin ligase > degradation by 26S proteasome > NF-kB free to translocate to the nucleus.
Answer
  • stimulation
  • degradation

Question 40

Question
In diseased cells NF-kB control is lost (aberrantly nuclear)
Answer
  • True
  • False

Question 41

Question
Which of the following do all members of the mammalian NF-KB family contain?
Answer
  • Rel homology domains
  • Leucine zipper like domain
  • Non conserved transcription activation domains
  • PEST domains
  • ankyrin repeat motifs
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