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Coagulation and Coagulation Disorders

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Haematology and Anatomy (Coagulation) Quiz on Coagulation and Coagulation Disorders, created by gina_evans0312 on 09/01/2014.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 almost 11 years ago
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Resource summary

Question 1

Question
The Extrinsic Pathway operates on the initiating cell
Answer
  • True
  • False

Question 2

Question
What is the role of the Extrinsic Pathway?
Answer
  • Coagulation initiation
  • Formation of the fibrin plug
  • Activation of Factor V

Question 3

Question
The Intrinsic Pathway works on...
Answer
  • The endothelium
  • The vW factor
  • The platelet surface

Question 4

Question
The Intrinsic pathway is designed to generate thrombin bursts
Answer
  • True
  • False

Question 5

Question
Name the three steps of Coagulation
Answer
  • Initiation
  • Amplification
  • Propagation

Question 6

Question
What begins the Initiation phase?
Answer
  • Vascular injury initiates trigger factor
  • Vascular injury exposes collagen for platelets to bind
  • Vascular injury causes blood cells to lyse

Question 7

Question
Trigger factor activates VII, which activates smal amounts of
Answer
  • IX
  • X
  • XI

Question 8

Question
X & XI bind to platelets and produce small amounts of Thrombulin
Answer
  • True
  • False

Question 9

Question
Thrombin initiates Amplification
Answer
  • True
  • False

Question 10

Question
The platelets act as a surface for the assembly of what factor complexes?
Answer
  • IX & VIII
  • Prethrombinase (X & V)

Question 11

Question
What happens in Propogation
Answer
  • Activated platelets/complexes generate Thrombin Burst
  • Activated platelets/complexes generate Thrombulin Burst
  • Activated platelets/complexes generate Thromblin Burst

Question 12

Question
What two things are required for Fibrin Clot formation?
Answer
  • Fibrinogen --> Fibrin
  • F IIa
  • F III
  • F V

Question 13

Question
Thrombin production is the crucial step in haemostasis
Answer
  • True
  • False

Question 14

Question
The first step in Coagulation Disorder diagnosis is a family & drug history
Answer
  • True
  • False

Question 15

Question
Name the two main clinical presentation of coagulation disorders
Answer
  • Bleeding in deep tissues
  • Bleeding in joints
  • Flushed skin
  • Easy cutting of skin

Question 16

Question
Prethrombin Time is anassessment of the _ Pathway
Answer
  • Extrinsic
  • Instrinsic

Question 17

Question
Prethrombin time is expressed as an international, normalised ratio
Answer
  • True
  • False

Question 18

Question
Activated Partial Thromboplastin Time is an indicator of...
Answer
  • Intrinsic pathway
  • Extrinsic pathway

Question 19

Question
Which of the following are not Coagulation Disorder investigations?
Answer
  • Fibrinogen Assay
  • FXIII Screen
  • Thrombin Clotting Time
  • Fibin Clotting Time

Question 20

Question
How do you evaluate increased prethrombin time?
Answer
  • Mix with normal platelets (50:50)
  • Remove half the platelets from a sample
  • Then a Factor VII assay

Question 21

Question
How do you evaluate Activated Partial Thromboplastin Time (APPT)?
Answer
  • Mix with normal plasma
  • Then do a Factor VIII, IX, XI assay
  • Then a FXII assay

Question 22

Question
Lack o Factor X causes no symptoms
Answer
  • True
  • False

Question 23

Question
Factor I assay is used if bot PT and APTT is elevated
Answer
  • True
  • False

Question 24

Question
If both PT and APTT is normal, what is tested for?
Answer
  • Factor XIII
  • TCT
  • Factor X

Question 25

Question
Aquired Coagulation Deficiencies are caused by a lack of what?
Answer
  • Vit A
  • Vit B
  • Vic D
  • Vit K

Question 26

Question
What can cause Aquired Vit K deficiency?
Answer
  • DIC
  • Massive Transfusion Effect
  • Malabsorption

Question 27

Question
Vit-K deficiency can be drug induced i.e. in the case of liver disease
Answer
  • True
  • False

Question 28

Question
Haemophilia A is caused by what?
Answer
  • Factor VIII deficiency
  • Factor VI deficiency
  • Factor V deficiency

Question 29

Question
Haemophilia A is sex linked
Answer
  • True
  • False

Question 30

Question
Haemophilia B is a Factor IX deficiency
Answer
  • True
  • False

Question 31

Question
The mutations for Haemophilia A & B are found on which chromosome?
Answer
  • X
  • Y

Question 32

Question
How do you identify Haemophilia B?
Answer
  • Inc PT
  • Inc APTT
  • Factor IX assay

Question 33

Question
Von Willebrands disease is caused by a lack of factor
Answer
  • VIII
  • VII
  • VI

Question 34

Question
vW disease is detected by
Answer
  • FVIII Assay
  • vWF assay

Question 35

Question
Since many things can effect the levels of vWF, testing is difficult
Answer
  • True
  • False

Question 36

Question
vW disease can be qualitative or quantitative
Answer
  • True
  • False
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