Therapeutic Index

therapeutic index: disease cured, measurable improvementex 1. diabetes - decrease blood glucoseex 2. hypertension- decrease in blood pressure**therapeutic index not affected by half life of the drug** save drugs have a ti of > 1000The graph: therapeutic index(ti)= LD5/ED95LD5(lethal dose): dose that is lethal to 5% of the populationED95(effective dose): dose that produces a therapeutic response or desired effect in 95% of the populationx (horizontal)- the dose of the drugy (vertical)- % patients respondingblack: therapeuticred: toxic effect (death or some kind of severe side effects)