11677938
Descripción
Test por Melanie Grynsztejn, actualizado hace más de 1 año
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Creado por Melanie Grynsztejn
hace casi 7 años
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Pregunta 1
Pregunta
Which beta blockers block both beta & alpha receptors?
Respuesta
-
Labetol
-
Carvedilol
-
Propanolol
-
Metroprolol
Pregunta 2
Pregunta
Beta‐1, found primarily in [blank_start]heart muscle[blank_end], results in increased heart rate, contractility, and atrioventricular (AV) conduction
Respuesta
-
heart muscle
-
bronchial & peripheral smooth muscle
-
adipose
Pregunta 3
Pregunta
Beta‐2, found in [blank_start]bronchial and peripheral vascular[blank_end] smooth muscle; results in vasodilatation and bronchodilation.
Respuesta
-
bronchial and peripheral vascular
-
heart muscle
-
adipose
Pregunta 4
Pregunta
Beta‐3, found in [blank_start]adipose tissue and the heart;[blank_end] may reduce cardiac contractility.
Respuesta
-
adipose tissue and the heart;
-
heart muscle
-
bronchial and peripheral vascular smooth
Pregunta 5
Pregunta
Beta blockers MOA:
Respuesta
-
Competitively inhibiting catecholamines from binding to these receptors.
-
Dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle
-
Act on vascular smooth muscle to reduce contraction of the arteries and cause vasodilation
Pregunta 6
Pregunta
Which of the following Beta Blockers are eliminated by hepatic metabolism and are lipid soluble
Respuesta
-
Propranolol
-
Metoprolol
-
Atenolol
-
Sotalol
Pregunta 7
Pregunta
Why is important to know which BB are eliminated by hepatic metabolism and more lipid soluble?
Respuesta
-
Enter CNS in high concentrations, possibly resulting in an increased incidence of CNS side effects
-
Are eliminated and do not as readily enter the CNS so can be prescribed more readily
-
Can cause hepatic damage if prescribed in too high a dosage
Pregunta 8
Pregunta
Which of the following beta blockers are excreted unchanged by the kidney?
Respuesta
-
Atenolol
-
Sotalol
-
Propranolol
-
Metoprolol
Pregunta 9
Pregunta
Metoprolol tartrate is [blank_start]shorter‐acting[blank_end] and dose [blank_start]*twice*[blank_end] daily and
Metoprolol succinate [blank_start]longer‐ acting[blank_end] and dosed [blank_start]*once*[blank_end] daily
Respuesta
-
shorter‐acting
-
longer-acting
-
*twice*
-
*once*
-
longer‐ acting
-
shorter-acting
-
*once*
-
*twice*
Pregunta 10
Pregunta
Atenolol and sotalol are more water soluble and are eliminated unchanged by the kidney. What is the effect of this on plasma half-lives & bioavailability?
Respuesta
-
Longer plasma half-life
-
Shorter plasma half-life
-
Greater bioavailability
-
Lesser bioavailability
Pregunta 11
Pregunta
True or False:
BB are first-line therapy to reduce angina episodes & increase exercise tolerance
Respuesta
- True
- False
Pregunta 12
Pregunta
BB & CCB are antianginal drugs proven to prevent reinfarction and improve survival in patients who have sustained a MI
Respuesta
- True
- False
Pregunta 13
Pregunta
BB should NOT be used in which type of angina patient
Respuesta
-
Stable
-
Unstable
-
Vasospastic (Prinzmetal)
Pregunta 14
Pregunta
It is important to [blank_start]taper[blank_end] BB when discontinuing BB therapy
Respuesta
-
taper
Pregunta 15
Pregunta
What are some potential Adverse Effects of Beta Blockers
Respuesta
-
Decreased heart rate, contractility & AV node conduction
-
Increased heart rate, contractility & AV node conduction
-
Bronchoconstriction
-
Bronchodilation
-
Nightmares, Insomnia, hallucinations
-
Depression
-
Weight loss
-
Weight gain
-
Erectile dysfunction
Pregunta 16
Pregunta
T or F
CCB are less effective than BB when treating stable angina
Respuesta
- True
- False
Pregunta 17
Pregunta
When are CCB used to treat stable angina?
Respuesta
-
When BB is not successful
-
When BB is contraindicated
-
When BB are causing SE
-
Are never combined with BB
Pregunta 18
Pregunta
What is the caution for using both non‐dihydropyridine and BB?
Respuesta
-
Additive bradycardia
-
Orthostatic hypotension
-
Weakness
-
N/V/D
Pregunta 19
Pregunta
CCB improve anginal symptoms by causing coronary and [blank_start]peripheral[blank_end] vasodilatation and [blank_start]reducing[blank_end] contractility
Respuesta
-
peripheral
-
central
-
reducing
-
increasing
Pregunta 20
Pregunta
Select the non-dihydropyridine CCB:
Respuesta
-
Diltiazem
-
Verapamil
-
Amlodipine
-
Felodipine
-
Nifedipine
Pregunta 21
Pregunta
Which types of CCB are preferred for angina
Respuesta
-
Long-acting non-dihydropyridine CCB - Verapamil & Diltiazem
-
Second generation CCB - Amlodipine or Felodipine
-
1st generation CCB - Nifidepine
Pregunta 22
Pregunta
What is the most concerning adverse effect of dihyrdropyridine (amlodipine, felodipine, nifedipine
Respuesta
-
Peripheral edema
-
Lightheadedness
-
Flushing
Pregunta 23
Pregunta
What are potential adverse effects of Dihydropyridines
Respuesta
-
Constipation
-
Bradycardia
-
Peripheral edema
-
Lightheadness
-
Flushing
-
Headache
Pregunta 24
Pregunta
What are potential adverse effects of non-dihydropyridines
Respuesta
-
Bradycardia
-
Constipation
-
Peripheral edema
-
Headache
-
Lightheadedness
-
Flushing
Pregunta 25
Pregunta
What are a prescribers options if a patient gets peripheral edema on a dihydropyridines?
Respuesta
-
Reduce dose
-
Add an angiotensin‐converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB)
-
Switch to a non‐dihydropyridine agent
-
Add a metered dose spray nitrate
Pregunta 26
Pregunta
MOA for nitrate used for stable angina is
Respuesta
-
Dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle.
-
Competitively inhibiting catecholamines from binding to these receptors.
-
Act on vascular smooth muscle reducing contraction of the arteries and causing vasodilation
Pregunta 27
Pregunta
Select the cardioselective beta blockers
Respuesta
-
Atenolol
-
Metoprolol
-
Propranolol
Pregunta 28
Pregunta
Select the non-cardioselective beta blockers
Respuesta
-
Meoprolol
-
Atenolol
-
Propranolol
Pregunta 29
Pregunta
Nitrates are used as
Respuesta
-
First‐line therapy for the treatment of acute anginal
-
Prophylactically for activities known to elicit angina
-
Ongoing management of stable angina
Pregunta 30
Pregunta
Usually in the form of a sublingual preparation, nitrates onset of action is within [blank_start]2‐5 minutes[blank_end] and duration of action [blank_start]15‐30 minutes[blank_end]
Respuesta
-
2‐5 minutes
-
5 - 10 minutes
-
1 - 2 minutes
-
15 ‐ 30 minutes
-
5 - 10 minutes
-
10 - 20 minutes
-
15 - 20 minutes
Pregunta 31
Pregunta
Select the potential adverse effects of nitrates
Respuesta
-
Hypotension
-
Flushing
-
Bradycardia
-
Headache
-
N/V/D
-
LIghtheadedness
Pregunta 32
Pregunta
American College of Cardiology/American Heart Association (ACC/AHA) guidelines for calling the emergency services are
Respuesta
-
Contact EMS if chest pain or discomfort is unimproved or worsening 5 minutes after *one* nitroglycerin dose has been taken sublingually
-
Take one nitroglycerin dose sublingually every 5 minutes for up to *3 doses* before calling for emergency medical services evaluation.
Pregunta 33
Pregunta
Nitroglycerin tablets are both [blank_start]heat[blank_end] and [blank_start]light[blank_end] sensitive
Respuesta
-
heat
-
light
Pregunta 34
Pregunta
Nitroglycerin tablets should be stored in a tightly capped dark bottle in the refrigerator with only a small supply being carried by the patient and discarded after 12 months
Respuesta
- True
- False
Pregunta 35
Pregunta
The following are longer-acting nitrate therapies
Respuesta
-
Nitroglycerin table
-
Isosorbide dinitrate
-
Isosorbide mononitrate
-
Transdermal nitroglycerin patch
Pregunta 36
Pregunta
How can a patient address the issue of nitrate tolerance with long-term therapies like the transdermal nitroglycerin patch?
Respuesta
-
Nitrate‐free interval (at least approx 8‐10 hours)
-
Use patch on different sites on the body
-
Increase dosage of transdermal patch
-
Switch to short-term nitroglycerin tablet
Pregunta 37
Pregunta
What is a REALLY IMPORTANT nitrate contraindication drug
Respuesta
-
Warfarin (Coumadin)
-
Erectile dysfunction drugs, PDE-5, Sildenafil, Vardenafil or Tadalafil within 24 hours
-
Second generation dihydropyridine CCB drugs Amlodipine and Felodipine
-
Cardioselective BB drugs Atenolol and Metoprolol
Pregunta 38
Pregunta
Ranolazine is a new drug for stable angina that is recommended for patients that have failed all other antianginal therpies. However, it is contraindicated for the following patients
Respuesta
-
Pre-existing QT interval
-
Hepatic disease
-
Renal disease
-
Tachycardia
Pregunta 39
Pregunta
The following are angina PREVENTIVE therapies
Respuesta
-
ASA
-
Clopidogrel (Plavix) if allergic to aspirin
-
Verapamil if allergic to aspirin
-
Propranolol if allergic to aspiring
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