11684434
Descripción
Test por Melanie Grynsztejn, actualizado hace más de 1 año
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Creado por Melanie Grynsztejn
hace más de 6 años
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Pregunta 1
Pregunta
Pharmacogenetics is study of inherited genetics [blank_start]difference[blank_end] in drug [blank_start]metabolic[blank_end] pathways which can affect [blank_start]individual[blank_end] responses to drugs, both in terms of therapeutic effect as well as adverse effects
Respuesta
-
difference
-
sameness
-
metabolic
-
pharmacokinectic
-
individual
-
ethnic group's
Pregunta 2
Pregunta
Nearly [blank_start]90%[blank_end] of general population have CYP2D6 functional duplication allele
o [blank_start]10%[blank_end] has inactive copies of CYP2D6 = codeine has no analgesic effect
o [blank_start]2-5%[blank_end] ultrarapid metabolizer
Respuesta
-
90%
-
80%
-
70%
-
10%
-
20%
-
5%
-
2-5%
-
5-10%
-
10-15%
Pregunta 3
Pregunta
Codeine is metabolized by an enzyme that is genetically regulated called CYP2D6 in the liver that turns codeine into morphine
Respuesta
- True
- False
Pregunta 4
Pregunta
CYP2D6 is responsible for the metabolism of which drugs
Respuesta
-
Analgesics
-
BB
-
CCB
-
Antidepressants
-
Antispsychotics
Pregunta 5
Pregunta
The CYP2C19 metabolizes which drugs
Respuesta
-
Plavix (clopidogrel)
-
Coumadin (warfarin)
-
Dabigatran (Pradaxa)
-
Apixaban (Eliquis)
Pregunta 6
Pregunta
GeneSight Tests for
Respuesta
-
ADHD
-
Analgesic
-
MTHFR
-
Psychotropic
-
Anticoagulants
Pregunta 7
Pregunta
Genotype is
Respuesta
-
genetic constitution, alleles present at one locus
-
manifestation of genes
-
phenotypic differences
-
proportion of heterozygous population expressing the phenotype
Pregunta 8
Pregunta
Phenotype is:
Respuesta
-
genetic constitution, alleles present at one locus
-
manifestation of genotype
-
phenotypic differences in same genotype
-
proportion of heterozygous population expressing the phenotype
Pregunta 9
Pregunta
Variable expressivity is
Respuesta
-
genetic constitution, alleles present at one locus
-
manifestation of genotype
-
phenotypic differences in same genotype
-
proportion of heterozygous population expressing the phenotype
Pregunta 10
Pregunta
Penetrance is
Respuesta
-
genetic constitution, alleles present at one locus
-
manifestation of genotype
-
phenotypic differences in same genotype
-
proportion of heterozygous population expressing the phenotype
Pregunta 11
Pregunta
Autosomal dominant inheritance
Respuesta
-
Required one copy of gene mutation to express the associated condition
-
Phenotype is expressed in person heterozygous for a particular allele
-
Requires two copies of gene mutation (one from each parent) to manifest the condition
-
Phenotypes is expressed in person homozygous for a particular allele
Pregunta 12
Pregunta
Autosomal recessive:
Respuesta
-
Requires one copy of gene mutation to express the associated condition
-
Phenotype is expressed in person heterozygous for a particular allele
-
Requires two copies of gene mutation (one from each parent) to manifest the condition
-
Phenotypes is expressed in person homozygous for a particular allele
Pregunta 13
Pregunta
Breast cancer is [blank_start]5 - 10%[blank_end] hereditary
Respuesta
-
5 - 10%
-
0 - 5%
-
10 - 15%
-
15 - 20 %
Pregunta 14
Pregunta
Which a mutation in which BRCA gene has a 40% lifetime risk for ovarian cancer
Respuesta
-
BRCA-1
-
BRCA - 2
Pregunta 15
Pregunta
Tamoxifen is metabolized by
Respuesta
-
CYP2D6
-
CYP2CI9
Pregunta 16
Pregunta
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers including endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin
Respuesta
- True
- False
Pregunta 17
Pregunta
Amsterdam II criteria for HNPCC/Lynch Syndrome includes 3 relatives with CRC (colorectal cancer) and other HNPCC cancer in the family. Select the HNPCC cancers:
Respuesta
-
Hepatic
-
Colon
-
Endometrium
-
Small bowen
-
Pancreatic
-
Renal pelvis
Pregunta 18
Pregunta
Pharmacogenetics is the study of _________
Respuesta
-
germline mutations
-
x-linked mutations
-
autosomal dominant mutations
-
autosomal recessive mutations
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