12973931
Descripción
Test por Melanie Grynsztejn, actualizado hace más de 1 año
|
Creado por Melanie Grynsztejn
hace más de 6 años
|
|
Pregunta 1
Pregunta
The following are early onset EPS symptoms
Respuesta
-
Dystonia
-
Akathisia
-
Parkinsonism
-
Tardive dyskensia
Pregunta 2
Pregunta
Which EPS symtom can appear within days
Respuesta
-
Dystonia
-
Akatsia
-
Parkinsonism
-
Tardive dyskinesia
Pregunta 3
Pregunta
Which EPS symptom can appear within weeks?
Respuesta
-
Dystonia
-
Akathisia
-
Parkinsonsism
-
Tardive dyskenia
Pregunta 4
Pregunta
Which EPS symptom can appear within months?
Respuesta
-
Dystonia
-
Akathisia
-
Parkinsonism
-
Tardive dyskinesia
Pregunta 5
Pregunta
Which EPS symtoms can take years to appear?
Respuesta
-
Dystonia
-
Akathisia
-
Parkinsonism
-
Tardive dyskensia
Pregunta 6
Pregunta
Types of drug-induced movement disorders:
[blank_start]Acute:[blank_end] Occur within a short duration of treatment onset or dose increase
[blank_start]Chronic:[blank_end] Symptoms persist throughout treatment
[blank_start]Tardive[blank_end]: Delayed onset of symptoms
[blank_start]Withdrawal:[blank_end] Occur in the absence of treatment. May resolve
Respuesta
-
Acute:
-
Withdrawal:
-
Chronic:
-
Tardive
-
Tardive
-
Withdrawal
-
Withdrawal:
-
Tardive
Pregunta 7
Pregunta
Dopamine system pathways include:
Mesolimbic: arousal, memory, behavior
Mesocortical: cognition, socializaiont
Tuberoinfundibular: regulation of prolactin
Nigrostriatal: modulation of EPS
Respuesta
- True
- False
Pregunta 8
Respuesta
-
Dopamine deficiency in the basal ganglia and striatum
-
Overactive cholinergic system
-
Dopaminergic/serotonergic or dopaminergic/cholinergic imbalance in the nucleus accumbens
-
Blockade of the striatal dopamine receptors
Pregunta 9
Pregunta
What are risk factors for dystonia
Respuesta
-
Young age
-
H/O ECT
-
Male gender
-
High potency neuroleptics - Haldol, Prolixin
-
Comorbid medical conditions
Pregunta 10
Respuesta
-
Opisthotonos
-
Blepharospasm
-
Torticollis
-
Oculogyric crisis
-
Oro-mandibular
Pregunta 11
Pregunta
The MOA for akathisia, from the Greek meaning "inability to sit", is:
Respuesta
-
Dopamine deficiency in the basal ganglia and striatum
-
Dopaminergic/serotonergic or dopaminergic/cholinergic imbalance in the nucleus accumbens, Overstimulation of locus coeruleus.
-
Blockade of the striatal dopamine receptors
-
Striatal dopaminergic hypersensitivity
Pregunta 12
Pregunta
Which of the following agents cause akathisia
Respuesta
-
SSRI
-
Second generation antipsychotics
-
Antiemetics
-
CCB
-
Anti-anxiolytics
Pregunta 13
Pregunta
What are some differentials for akathisia
Respuesta
-
GAD
-
ADHD
-
Agitation
-
MDD
Pregunta 14
Pregunta
What are clinical presentation of akathisia
Respuesta
-
Restlessness
-
Breaking out into song & dance for no reason
-
Fidgety movements/leg swinging
-
Marching in place
-
Rocking from one foot to another
-
Picking
Pregunta 15
Pregunta
The risk factors for akathisia include
Respuesta
-
Advanced age
-
Affective disorder
-
Cognitive impairment
-
Female impersonator performer
-
Female
-
H/O akathisia
-
Iron deficiency
-
High dose/potency/neuroleptics
Pregunta 16
Pregunta
Pathophysiology of pseudoparkinsonism is:
Respuesta
-
Dopamine deficiency in the basal ganglia and striatum
-
Dopaminergic/serotonergic or dopaminergic/cholinergic imbalance in the nucleus accumbens
-
Blockade of the striatal dopamine receptors and depletion of pre-synaptic celft
-
Striatal dopaminergic hypersensitivity and cholinergic deficiency in the basal ganglia
Pregunta 17
Pregunta
Parkinsonism = [blank_start]bradykesia[blank_end]
Pseudoparkinsonism = [blank_start]apraxic slowness[blank_end]
Respuesta
-
bradykesia
-
apraxic slowness
-
bradykinesia
-
apraxic slowness
Pregunta 18
Pregunta
Parkinsonism = [blank_start]resting tremor[blank_end]
Pseudoparkinsonism = [blank_start]essential tremor, myoclonus[blank_end]
Respuesta
-
resting tremor
-
essential tremor, myoclonus
-
resting tremor
-
essential tremor, myoclonus
Pregunta 19
Pregunta
Parkinsonism = [blank_start]lead pipe rigidity[blank_end]
Pseudoparkinsonism = [blank_start]paratonic rigidity[blank_end]
Respuesta
-
lead pipe rigidity
-
paratonic rigidity
-
lead pipe rigidity
-
paratonic rigidity
Pregunta 20
Pregunta
Parkinsonism = [blank_start]postural instability[blank_end]
Pseudoparkinsonism = [blank_start]frontal ataxia[blank_end]
Respuesta
-
postural instability
-
frontal ataxia
-
postural instability
-
frontal ataxia
Pregunta 21
Pregunta
Parkinsonism = [blank_start]Slow, shuffling gait with festination[blank_end]
Pseudoparkinsonism = [blank_start]Slow, shuffling apraxic gait[blank_end]
Respuesta
-
Slow, shuffling gait with festination
-
Slow, shuffling apraxic gait
-
Slow, shuffling gait with festination
-
Slow, shuffling apraxic gait
Pregunta 22
Pregunta
What are risk factors for pseudoparkinsonism?
Respuesta
-
Female
-
Male
-
Advanced age
-
Central DA receptor binding agents, Metclopramide, phenothiazines
-
AIDS
-
Cancer
Pregunta 23
Pregunta
Tardive dyskinesia
Respuesta
-
If identified early can be reversed
-
is not reversible
-
increased risk with increased use
-
increased use does not cause increases risk
-
early onset
-
late onset
Pregunta 24
Pregunta
MOA for tardive dyskinesia
Respuesta
-
Striatal dopaminergic hypersensitivity
-
Cholinergic deficiency within basal ganglia
-
Oxidative stress and cell injur
-
Genetic susceptibility
-
Glutamate-induced excitotoxicity
-
GABA mediated neuronal dysfunction
-
Blockade of the striatal dopamine receptors
Pregunta 25
Pregunta
Which medications most commonly cause tardive dyskinesia?
Respuesta
-
Meoclopramide
-
Alpha adrenergic agonists
-
SGA
-
FGA
Pregunta 26
Pregunta
Clinical presention of tardive dyskinesia
Respuesta
-
Choreiform - characterized by jerky, involuntary movements, chiefly of the face and extremitiesImage:Chorea (binary/octet-stream)
-
Athetoid - characterized by slow, involuntary, convoluted, writhing movements of the fingers, hands, toes, and feet and in some cases, arms, legs, neck and tongue
-
Stereotypic - petitive, nonfunctional motor behavior (e.g., hand waving or head banging), that markedly interferes with normal activities or results in bodily injury.
Pregunta 27
Pregunta
EPS can be caused by antiemetics, antieliptics, psychotropics, cardiovascular agents and Levodopa
Respuesta
- True
- False
Pregunta 28
Pregunta
EPS can be caused by antiemetics, antieliptics, psychotropics, cardiovascular agents and Levodopa
Respuesta
- True
- False
Pregunta 29
Pregunta
The following drugs cause all four movement disorders: dystonia, akathisia, Parkinsonism, tardive dyskinesia
Respuesta
-
Metoclopramide
-
Prochloraperazine
-
Amoxapine
-
Neuroleptics
-
SSRI
-
Levodopa
Pregunta 30
Pregunta
How often should the Abnormal Involuntary Movement Scale (AIMS) be administered?
Respuesta
-
Baseline then every week x4 then every 3 months
-
Baseline then every week x2 then every 12 months
-
Baseline then every week x2 then every 6 months
Pregunta 31
Pregunta
What are overall tips for treatment of EPS?
Respuesta
-
Stop offending agen (if possible)
-
Reduce the dose
-
Switch to a second generation antipsychotic
-
Treat prophylactically
-
A wing and prayer and refer to anyone else
Pregunta 32
Pregunta
Dystonia put in order of line of treatment
First line = [blank_start]anticholinergic agents[blank_end]
Second line = [blank_start]Baclofen[blank_end]
Third line = [blank_start]Benzo[blank_end]
Fourth line - [blank_start]Botox[blank_end]
Respuesta
-
anticholinergic agents
-
Baclofen
-
Benzo
-
Botox
Pregunta 33
Respuesta
- True
- False
Pregunta 34
Pregunta
Drug of choice for dystonia is
Respuesta
-
Beta-blockers, anticholinergics, benzodiazepines, 5-HT2A receptor antagonist, mirtazapine
-
Anticholinergics (benztropine, diphenhydramine, trihexyphenidyl)
-
Clonzaepam, ginkgo biloba
Pregunta 35
Pregunta
Drugs of choice for akathisia include
Respuesta
-
Anticholinergics (benztropine, diphenhydramine, trihexyphenidyl)
-
Beta-blockers, benzodiazepines, 5-HT2A receptor antagonist, mirtazapine
-
Clonazepam, ginkgo biloba
Pregunta 36
Pregunta
Mirtazapine (Remeron)
Respuesta
-
Used in low doses to treat akathisa
-
Used in low doses to treat dystonia
-
Alpha-adrenergic receptor antagonist
-
Alpha-adrenergic receptor agonist
-
Antagonizes 5-HT2 and 3 receptors
Pregunta 37
Respuesta
- True
- False
Pregunta 38
Pregunta
Which drugs are used to treat pseudoparkinsonism?
Respuesta
-
Cogentin (benztropine)
-
Symmetrel (amantadine)
-
Benzodiazepines
-
Mirtazapine (Remeron)
-
Diphenhydramine (Benadryl)
Pregunta 39
Pregunta
MOA for amantadine (Symmetrel) is
Respuesta
-
Dopamine agonist
-
Dopamine antagonist
-
5-HT2 agonist
-
5-HT2 antagonist
Pregunta 40
Pregunta
Side effects for benztropine (Cogentin) include
Respuesta
-
Dry mouth
-
Hypotension
-
Diarrhea
-
Constipation
-
Cognitive impairment
-
Sialorrhea
Pregunta 41
Pregunta
Side effects for amantadine (Symmetrel) include:
Respuesta
-
Hypotension
-
Hypertension
-
Agitation
-
Sedation
-
Worsening s/s of psychosis
Pregunta 42
Pregunta
Which drugs are used in the treatment of tardive dyskinesia
Respuesta
-
Diltiazem
-
Baclofen
-
Galantamine
-
Clonazepam
-
Ginkgo biloba
Pregunta 43
Pregunta
What is the first FDA approved medication for Tardive Dyskinesia
Respuesta
-
Velbeazine (Ingrezza)
-
Benztropine (Cogentin)
-
Trihexphenidyl (Artane)
-
Amantadine (Symmetrel)
Pregunta 44
Pregunta
What is the MOA for valbenazine (Ingrezza)?
Respuesta
-
Blocks alpha-adrenergic receptors and antagonizes 5-HT2 and 3 receptors
-
Reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release
-
Increase in synthesis and release of dopamine, and inhibition of dopamine uptake.
-
Selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular)
Pregunta 45
Pregunta
Acute [blank_start]laryngeal[blank_end] dystonia is considered a medical emergency.
Must seek treatment immediately. May require IV diphenhydramine
Respuesta
-
laryngeal
Pregunta 46
Pregunta
Velbenazine is extensively metabolized by hydrolysis to form active metabolite
and by oxidative metabolism to form mono-oxidized valbenazine and other minor metabolites
Respuesta
- True
- False
Pregunta 47
Pregunta
High fat meals may [blank_start]decrease[blank_end] absorption of valbenazine (Ingrezza)
Respuesta
-
decrease
-
increase
Pregunta 48
Pregunta
Common adverse side effects of valbenazine (Ingrezza) include:
Respuesta
-
Fatigue
-
HA
-
Constipation
-
Diarrhea
-
UTI
-
Somnolence
Pregunta 49
Pregunta
Warnings for valbenazine (Ingrezza) include:
Respuesta
-
Somnolence
-
QTc prolongation
-
Pregnancy/breastfeeding
-
Hypertension
Pregunta 50
Pregunta
Valbenazine should not be used in:
Respuesta
-
Severe renal impairment (< 30 mL/min)
-
CHF
-
Cirrhosis
-
Pancreatitis
Pregunta 51
Pregunta
Strong 3A4/2D6 inhibitors: [blank_start]Increase[blank_end] valbenazine concentration
Strong 3A4 inducer: [blank_start]Decrease[blank_end] valbenazine concentration
Respuesta
-
Increase
-
Decrease
-
Increase
-
Decrease
Pregunta 52
Pregunta
Valbenazine (Ingrezza) interacts with MAOIs by [blank_start]increasing[blank_end] the monamine NT in the synapse
Respuesta
-
increasing
-
decreasing
Pregunta 53
Pregunta
Valbenazine (Ingrezza) interacts with digoxin and [blank_start]increase[blank_end]s the digoxin concentration by p-glycoprotein [blank_start]inhibtion[blank_end]
Respuesta
-
increase
-
decreases
-
inhibtion
-
inducer
Pregunta 54
Pregunta
Deutetrabenazine (Austedo) is used for the treatment of chorea and schizophrenia/schizoaffective disorder. It is metabolized by CYP2D6
Respuesta
- True
- False
¿Quieres crear tus propios Tests gratis con GoConqr? Más información.