14241210
Descripción
Test por Michael Jardine, actualizado hace más de 1 año
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Creado por Michael Jardine
hace más de 6 años
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Pregunta 1
Pregunta
(from end of L05 slides)
In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?
Respuesta
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Polymerase *probs* removes it, often via 3' exonuclease activity
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Polymerase *probs* removes it, often via 5' exonuclease activity
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Polymerase *probs* removes it, often via 3' endonuclease activity
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Polymerase *probs* removes it, often via 5' endonuclease activity
Pregunta 2
Pregunta
(from end of L05 slides)
How does a frameshift mutation differ from a missense mutation?
Respuesta
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Missense affects many codons; Frameshift mutation does not.
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Frameshift affects many codons; Missense mutation does not.
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Frameshift affects many codons; Missense mutation only affects 3.
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Missense affects many codons; Frameshift mutation only affects 3.
Pregunta 3
Pregunta
(from end of L05 slides)
Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain *here*, but be ready to)
Respuesta
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No.
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Yes.
Pregunta 4
Pregunta
DNA is replicated in:
Respuesta
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S phase
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M phase
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G phase
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Cytokinesis
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Telekinesis
Pregunta 5
Pregunta
UV:
Respuesta
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light has HIGH energy
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light has LOW energy
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damage forms a join between two adjacent bases, usually Thymine (forming a Thymine dimer)
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damage forms a join between two adjacent bases, usually Cytosine (forming a Cytosine dimer)
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damage forms a join between two adjacent bases, usually Adenosine (forming a Adenosine dimer)
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damage forms a join between two adjacent bases, usually Guanine (forming a Guanine dimer)
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damage forms a join between two adjacent bases, usually Adenine (forming a Adenine dimer)
Pregunta 6
Pregunta
Which of the following is NOT a type of DNA mutation (necessarily)?
Respuesta
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Indels
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Incels
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Transitions
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Transversions
Pregunta 7
Pregunta
Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks:
Silent mutation: [blank_start]________________[blank_end];
Missense mutation: [blank_start]________________[blank_end];
Nonsense mutation: [blank_start]________________[blank_end];
Frameshift [blank_start]________________[blank_end].
Respuesta
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bp change, NO amino acid sequence change
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bp change, amino acid change
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bp change, early stop codon
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1bp+ indel, alters reading frame
Pregunta 8
Pregunta
UV repair in humans is through:
Respuesta
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Nucleotide excision repair
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Enzyme photolyase
Pregunta 9
Pregunta
A mutation resulting in COPY NUMBER VARIATION can vary between identical twins. Therefore it happens during:
Respuesta
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Mitosis
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Meiosis
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Both of the above
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None of the above
Pregunta 10
Respuesta
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Gene expression of different members of a gene family varying in different parts of the same plant
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Gene expression of different members of a gene family varying in different stages of the same plant's development
Pregunta 11
Pregunta
(from end of L06 slides)
Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:
Respuesta
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promoters
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introns
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5’-UTR
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3’-UTR
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exons
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5’-URT
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3’-URT
Pregunta 12
Pregunta
Blonde vs brown-hair is an example of variation in:
Respuesta
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gene expression
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aa sequence
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gene splicing
Pregunta 13
Pregunta
(from end of L06 slides)
Define a gene family:
Respuesta
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A set of several similar genes, formed by duplication of a single original gene
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A set of several copies of identical genes, responsible for varying levels of a single trait
Pregunta 14
Pregunta
(from end of L06 slides)
What is a pseudogene?
Respuesta
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A non-functional copy of a gene including a regulatory mutation that prevents its expression
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A non-functional copy of a gene including a premature stop codon within the gene that prevents its expression
Pregunta 15
Pregunta
(from end of L06 slides)
What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)
Respuesta
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Variation in amino acid sequences
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Regulatory sequences
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Variation in gene number
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Variation in splicing
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Novel genes
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