Brain imaging

Descripción

Lecture 4
Jennifer Khouw
Test por Jennifer Khouw, actualizado hace más de 1 año
Jennifer Khouw
Creado por Jennifer Khouw hace alrededor de 6 años
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Resumen del Recurso

Pregunta 1

Pregunta
Which are structural techniques?
Respuesta
  • X-ray and CT
  • MRI
  • Contrast agents
  • Diffusion Tensor Imaging
  • PET
  • fMRI
  • EEG
  • MEG
  • ECoG

Pregunta 2

Pregunta
Which are functional techniques?
Respuesta
  • PET
  • fMRI
  • EEG
  • MEG
  • ECoG
  • MRI
  • CT

Pregunta 3

Pregunta
X-ray and CT techniques are great at showing:
Respuesta
  • Blood vessels
  • Different brain regions
  • Ventricles
  • Electrical activity

Pregunta 4

Pregunta
_________ ventricles could be due to tumour; _________ ventricles could be due to schizophrenia
Respuesta
  • Shrunken; expanded
  • Expanded; shrunken

Pregunta 5

Pregunta
Which technique measures proton densities?
Respuesta
  • MRI
  • Contrast agents
  • PET
  • Electrocorticography

Pregunta 6

Pregunta
What is the most common contrast agent?
Respuesta
  • Gadolinium
  • TM tomato
  • Haemoglobin
  • Phosphorescents

Pregunta 7

Pregunta
What is true of Diffusion Tensor Imaging?
Respuesta
  • Shows fibre tracts
  • Measures hydrogen densities
  • Is a structural MRI technique
  • Water molecules diffuse more easily through the cross-section of neurons than along the long axis
  • Makes a lot of assumptions

Pregunta 8

Pregunta
Which technique involves the injection of a radioactive isotope?
Respuesta
  • CT
  • PET
  • Electrocorticography
  • MEG
  • Diffusion Tensor Imaging

Pregunta 9

Pregunta
What are examples of radioactive isotopes?
Respuesta
  • Oxygen
  • Glucose
  • Gadolinium
  • Tm tomato

Pregunta 10

Pregunta
The brain takes about [blank_start]3[blank_end]% of the body's weight, but uses about [blank_start]20[blank_end]% of its nutrients
Respuesta
  • 3
  • 20

Pregunta 11

Pregunta
What is true of Regional Cerebral Blood Flow (rCBF)?
Respuesta
  • Active regions release Nitrous Oxide to local arterioles
  • Nitrous Oxide released retroactively
  • Causes arterioles to constrict
  • Very slow change
  • Causes change in ratio of de:oxygenated blood

Pregunta 12

Pregunta
Which techniques are based on the close association between vasculature and metabolism?
Respuesta
  • fMRI
  • PET
  • EEG
  • MEG
  • Contrast agents

Pregunta 13

Pregunta
Which techniques measure electromagnetic fields generated by ionic current flow in active neurons?
Respuesta
  • EEG
  • MEG
  • fMRI
  • PET
  • Contrast agents

Pregunta 14

Pregunta
Which techniques are invasive?
Respuesta
  • MRI
  • PET
  • Electrocorticography
  • EEG
  • MEG

Pregunta 15

Pregunta
Which technique involves placing grids of electrodes directly on the surface of the brain?
Respuesta
  • Single-unit recording
  • Electrocorticography
  • Diffusion tensor imaging
  • Contrast X-ray angiography

Pregunta 16

Pregunta
When is Electrocorticography used?
Respuesta
  • Localise epileptic foci
  • Opportunistic research
  • Avoid eloquent areas during surgery
  • Research into language
  • Patients with mild clinical problems

Pregunta 17

Pregunta
What does MEG measure?
Respuesta
  • Strength of magnetic field
  • Strength of electrical field
  • Location of magnetic field
  • Location of electrical field

Pregunta 18

Pregunta
What is contained in a "dewer" and used to keep the SQUID close to absolute zero?
Respuesta
  • Liquid helium
  • Nitrous oxide
  • Dry ice
  • Hydrogen

Pregunta 19

Pregunta
Why do MRI scans have to be done after MEG?
Respuesta
  • Because MRI scans magnetize tissues for weeks
  • Due to risk of overheating the machine

Pregunta 20

Pregunta
Which technique induces electrical current flow by producing strong magnetic fields?
Respuesta
  • TMS
  • TES
  • TDS
  • tDCS

Pregunta 21

Pregunta
Which technique delivers a small electrical current?
Respuesta
  • TMS
  • tCDS
  • TES
  • EEG

Pregunta 22

Pregunta
Which is true of children's Fusiform gyrus response to faces, compared to adults:
Respuesta
  • Equally strong but later
  • Weaker and later
  • Stronger and earlier
  • Children's fusiform gyrus does not respond to face stimuli

Pregunta 23

Pregunta
What is true of standard template brains?
Respuesta
  • Normalise brains
  • Allows statistical analyses on brain maps
  • Is a standard size and shape
  • Used for structural brain images

Pregunta 24

Pregunta
Which standard template brain is based on a single well-characterised brain?
Respuesta
  • Talairach atlas
  • MNI atlas
  • Tesseract atlas
  • Monoamine atlas

Pregunta 25

Pregunta
Which standard template brain is based on an average of hundreds of MRI scans?
Respuesta
  • MNI atlas
  • Talairach atlas
  • Tesseract atlas

Pregunta 26

Pregunta
When is fMRI mostly used?
Respuesta
  • Clinically
  • Research
  • Pre-surgical and radiotherapy planning
  • Identify eloquent cortices

Pregunta 27

Pregunta
When is MEG usually used?
Respuesta
  • Rarely in hospitals
  • Localising epileptic foci
  • Pre-surgery mapping of eloquent cortices
  • Research

Pregunta 28

Pregunta
What is true of hippocampal theta oscillations?
Respuesta
  • Very active in novel environments
  • Ties together place cells
  • Tuned to specific locations in an environment
  • Different place cells fire at different phases of the theta oscillation
  • Important for semantic memory
  • Measured by EEG

Pregunta 29

Pregunta
Which regions make up the Default Mode Network?
Respuesta
  • Cingulate
  • Parietal
  • Frontal
  • Temporal
  • Occipital
  • Limbic
  • Diencephalonic

Pregunta 30

Pregunta
Which techniques are based on machine-learning?
Respuesta
  • Connectivity
  • Decoding
  • Connectomics
  • Machine reading

Pregunta 31

Pregunta
What is true of Connectivity analysis?
Respuesta
  • Based on graph theory
  • Emphasises brain structures over brain networks
  • Multi-voxel pattern analysis
  • Based on machine-learning

Pregunta 32

Pregunta
What is true of Decoding techniques?
Respuesta
  • Multi-voxel pattern analysis
  • Analyses patterns of activity to complex stimuli
  • Analyses patterns of activity to simple stimuli
  • Based on graph theory
  • Based on machine-learning

Pregunta 33

Pregunta
Why is the reproducibility crisis particularly acute in neuroimaging?
Respuesta
  • Huge amount of data
  • Increased possibilty of false positives
  • Too expensive to have large samples
  • Large researcher degrees of freedom
  • Statistical double-dipping
  • Results tend to have a large impact on society
  • Pre-registration of hypotheses
  • Data sharing

Pregunta 34

Pregunta
How has fMRI improved?
Respuesta
  • Gone from 1.5 T to 7 T
  • Better image stability
  • Better signal:noise ratio
  • Strongest magnets can reslve activity in different cortical layers
  • Higher temporal resolution

Pregunta 35

Pregunta
How has MEG improved?
Respuesta
  • Moving from SQUID to Optically Pumped Magnetometers
  • Human Neocortical Neurosolver
  • Dramatically improved data acquisition capabilities
  • Strongest magnets can resolve activity in different cortical layers

Pregunta 36

Pregunta
What are Optically Pumped Magnetometers?
Respuesta
  • Require liquid helium
  • Sensors placed directly on scalp
  • But reduced signal:noise ratio
  • Uses computers to map underlying circuit-level activity
  • Only one place in the world has them

Pregunta 37

Pregunta
Why isn't neuroimaging useful for psychiatric diagnosis?
Respuesta
  • Low specificity
  • High sensitivity
  • High standardization
  • Most psychiatric imaging studies are done on groups
  • Different disorders have similar neural patterns
  • DSM has much higher validity

Pregunta 38

Pregunta
Who said that we are currently not able to use brain imaging for psychiatric diagnoses, and may not ever be?
Respuesta
  • Farah & Gillihan
  • Aubertin & Bouillaud
  • Flouren & Gerschwind

Pregunta 39

Pregunta
Aside from diagnosis, why might brain imaging be useful in psychiatry?
Respuesta
  • Can suggest new treatments
  • DBS came from identifying deep brain areas that are hypoactive in depression
  • Quantifying and predicting treatment response
  • Classifying syndromes based on neuroimaging profile
  • Real-time neurofeedback may be a treatment in itself
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