Adrenegic Drugs- Pharmacology 4th Year- PMU

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Adrenegic Drugs- Pharmacology 4th Year- PMU
Med Student
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Med Student
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Resumen del Recurso

Pregunta 1

Pregunta
According to their mechanism of action the adrenergic agonists can be divided in:
Respuesta
  • direct agonists
  • indirect agonists
  • agonists with mixed mechanism of action
  • natural compounds

Pregunta 2

Pregunta
α1-adrenoceptors are located on:
Respuesta
  • presynaptic neuronal endings
  • postsynaptic neuronal endings
  • blood vessels
  • iris dilator muscle

Pregunta 3

Pregunta
β1-adrenoceptors are located on:
Respuesta
  • postsynaptic neuronal endings
  • presynaptic neuronal endings
  • myocardial cells
  • juxtaglomerular apparatus in the kidney

Pregunta 4

Pregunta
β2-adrenoceptors are located on:
Respuesta
  • postsynaptic neuronal endings
  • bronchial smooth muscles
  • liver
  • uterus (womb)

Pregunta 5

Pregunta
β3-adrenoceptors are located in:
Respuesta
  • adipose tissue
  • urinary bladder
  • presynaptic neuronal endings
  • bronchial smooth muscles

Pregunta 6

Pregunta
Pharmacological effects of Epinephrine are:
Respuesta
  • positive chronotropic effect
  • blood pressure elevation
  • bronchial smooth muscles dilation
  • elevated levels of blood sugar

Pregunta 7

Pregunta
Indications for the clinical use of Epinephrine are:
Respuesta
  • anaphylactic shock
  • hypoglycaemia
  • arrhythmia
  • glaucoma with wide iridocorneal angle

Pregunta 8

Pregunta
Potential adverse drug reactions of Epinephrine are:
Respuesta
  • hypoglycaemia
  • arrhythmia
  • tremor
  • anxiety and restlessness

Pregunta 9

Pregunta
Clinical indications for prescribing α1-agonists are:
Respuesta
  • arterial hypotension
  • acute rhinitis
  • asthma attack
  • heart block

Pregunta 10

Pregunta
Pharmacological effects of the selective β2-agonists are:
Respuesta
  • pupillary dilation
  • bronchial dilation
  • blood pressure elevation
  • relaxation of uterine muscle

Pregunta 11

Pregunta
Which of the following drugs are selective β2-agonists?
Respuesta
  • lsoprenalini sulfas
  • Orciprenalini sulfas
  • Salbutamol
  • Salmeterol

Pregunta 12

Pregunta
β2-agonists are indicated in:
Respuesta
  • bronchial asthma
  • digitalis intoxication
  • arterial hypertension
  • threatening abortion

Pregunta 13

Pregunta
Adverse drug reactions of β2-agonists are:
Respuesta
  • finger tremor
  • bronchial dilatation
  • hyperglycemia
  • tolerance

Pregunta 14

Pregunta
What are the main features of the indirect-acting adrenergic agonists?
Respuesta
  • stimulation of central nervous system
  • drug tolerance and dependence
  • have no effect on the cardio-vascular system
  • used for treatment of narcolepsy and attention deficiency hyperactivity disorder (ADHD)

Pregunta 15

Pregunta
Clinically desirable interactions can occur between β2-agonists and:(find correct answer)
Respuesta
  • tricyclic antidepressants
  • inhaled corticosteroids
  • inhaled antimuscarinic drugs
  • beta blockers

Pregunta 16

Pregunta
Mechanisms of action of the presynaptic adrenolytics are:
Respuesta
  • blockade of the presynaptic α2-receptors
  • activation of the presynaptic α2-receptors
  • conversion to a “false“ neurotransmitter
  • blockade of the phosphodiesterase enzyme

Pregunta 17

Pregunta
Which of the following drugs act as agonists of the presynaptic α2-adrenoceptors?
Respuesta
  • Salbutamol
  • Clonidini hydrochloridum
  • α-Methyldopum (Dopegyt)
  • Sotalol

Pregunta 18

Pregunta
Pharmacological effects of Clonidin are:
Respuesta
  • decreased peripheral vascular resistance
  • antihypertensive
  • inhibition of gastric secretion
  • antiarrhythmic

Pregunta 19

Pregunta
Adverse drug reactions of Clonidin are:
Respuesta
  • Dry mouth
  • Drowsiness and depression
  • Hypertensive attacks following abrupt cessation of treatment
  • CNS stimulation

Pregunta 20

Pregunta
For Methyldopa is true:
Respuesta
  • has antihypertensive effect
  • it is safe in pregnancy
  • could cause drug-induced parkinsonism
  • used to treat threatening abortion

Pregunta 21

Pregunta
Which of the following drugs are α1-adrenoblockers?
Respuesta
  • Prazosin
  • Doxazosin
  • Clonidin
  • Chlorpromazin

Pregunta 22

Pregunta
Pharmacological effects of Prazosin are:
Respuesta
  • dilation of the resistive and capacitive vessels
  • antihypertensive
  • relaxation of the muscles in the prostate and bladder neck
  • hyperglycaemia

Pregunta 23

Pregunta
Adverse drug reactions of α1-adrenoblockers are:
Respuesta
  • orthostatic collapse
  • hypokalemia
  • fluid retention
  • hypoglycaemia

Pregunta 24

Pregunta
Which of the following drugs are non-selective β-blockers?
Respuesta
  • Atenolol
  • Pindolol
  • Acebutolol
  • Propranolol

Pregunta 25

Pregunta
Which of the following drugs are selective β1-blockers?
Respuesta
  • Atenolol
  • Pindolol
  • Propranolol
  • Metoprolol

Pregunta 26

Pregunta
β-blockers are indicated in case of:
Respuesta
  • hypertension
  • bronchial asthma
  • arrhythmia
  • ischaemic heart disease

Pregunta 27

Pregunta
Pharmacological effects of B-blockers are:
Respuesta
  • bronchodilation
  • negative inotropic effect
  • positive chronotropic effect
  • negative chronotropic effect

Pregunta 28

Pregunta
β-blocker approved for topical use in treatment of glaucoma is:
Respuesta
  • Bisoprolol
  • Metoprolol
  • Timolol
  • Propranolol

Pregunta 29

Pregunta
When applied topically in the eye the B-blocker Timolol will:
Respuesta
  • increase the intraocular pressure
  • decrease the intraocular pressure
  • cause miosis
  • cause mydriasis

Pregunta 30

Pregunta
Potential adverse drug reactions of β-blockers are.
Respuesta
  • hypoglycaemia
  • bronchoconstriction
  • hyperglycaemia
  • nightmares

Pregunta 31

Pregunta
For long-term treatment with β-blockers is true:
Respuesta
  • up-regulation of B-adrenergic receptors
  • down-regulation of B-adrenergic receptors
  • the therapy should be ceased abruptly
  • the therapy should not be ceased abruptly
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