Pregunta 1
Pregunta
The urinary excretion product measured as an indicator of epinephrine production is:
Pregunta 2
Pregunta
Which two conditions can 'physiologically" elevate serum alkaline phosphatase?
Respuesta
-
rickets, hyperparathyroidism
-
obstructive jaundice, biliary cirrhosis
-
growth, third trimester of pregnancy
-
viral hepatitis, infectious mononucleosis
Pregunta 3
Pregunta
The T3 resin uptake test is a measure of:
Pregunta 4
Pregunta
During an evaluation of adrenal function, a patient had plasma cortisol levels in the morning after awakening and in the evening. Laboratory results indicated that the morning value was higher than the evening concentration. This is indicative of:
Respuesta
-
a normal finding
-
Cushing's syndrome
-
Addison's disease
-
hypopituitarism
Pregunta 5
Pregunta
In the liver, bilirubin is converted to:
Pregunta 6
Pregunta
The following results were obtained in a creatinine clearance evaluation:
Urine concentration 84 mg/dL
Urine volume 1440 mLI24 hr
Serum concentration 1.4 mg/dL
Body surface area 1.60 m2 (average = 1.73 m2)
The creatinine clearance in mL/min is:
Pregunta 7
Pregunta
The electrophoretic pattern of a plasma sample compared with a serum sample show a:
Pregunta 8
Pregunta
The biuret reaction for the analysis of serum protein depends on the number of:
Respuesta
-
free amino groups
-
free carboxyl groups
-
peptide bonds
-
tyrosine residues
Pregunta 9
Pregunta
Total iron-binding capacity measures the serum iron transporting capacity of:
Respuesta
-
hemoglobin
-
ceruloplasmin
-
transferrin
-
ferritin
Pregunta 10
Pregunta
In the Jendrassik-Grof method for serum bilirubin, quantitation is obtained by measuring the green color of:
Respuesta
-
azobilirubin
-
bilirubin glucuronide
-
urobilin
-
urobilinogen
Pregunta 11
Pregunta
Absorbance (A) of a solution may be converted to percent transmittance (%T) using the formula:
Respuesta
-
1+log%T
-
2+log%T
-
1-log%T
-
2-log%T
Pregunta 12
Pregunta
Aspartate aminotransferase and alanine aminotransferase are both elevated in which of the following diseases?
Respuesta
-
muscular dystrophy
-
viral hepatitis
-
pulmonary emboli
-
infectious mononucleosis
Pregunta 13
Pregunta
Calcium concentration in the serum is regulated by:
Respuesta
-
insulin
-
parathyroid hormone
-
thyroxine
-
vitamin C
Pregunta 14
Pregunta
Which of the following steroids is an adrenal cortical hormone'?
Respuesta
-
angiotensinogen
-
corticosterone
-
progesterone
-
pregnanetriol
Pregunta 15
Pregunta
Blood PCO2 may be measured by:
Respuesta
-
direct colorimetric measurement of dissolved C02
-
calculations of blood pH and total CO2 concentration
-
measurement of C02-saturated hemoglobin
-
measurement of CO2 consumed at the cathode
Pregunta 16
Pregunta
In the potentiometric measurement of hydrogen ion concentration, reference electrodes that may be used include:
Respuesta
-
silver-silver chloride
-
quinhydrone
-
hydroxide
-
hydrogen
Pregunta 17
Pregunta
The osmolality of a urine or serum specimen is measured by a change in the:
Respuesta
-
freezing point
-
sediment point
-
midpoint
-
osmotic pressure
Pregunta 18
Pregunta
In a spectrophotometer, light of a specific wavelength can be isolated from white light with
Respuesta
-
double beam
-
diffraction grating
-
aperture
-
slit
Pregunta 19
Pregunta
Which of the following is unstable if a blood specimen is left standing at room temp. for 8 hours before processing?
Respuesta
-
cholesterol
-
triglyceride
-
creatinine
-
glucose
Pregunta 20
Pregunta
A urine screening test for porphobilinogen is positive The MC)~T likely disease state is'
Pregunta 21
Pregunta
in electrophoretic analysis buffers
Pregunta 22
Pregunta
A condition in which erythrocyte protoporphyrin is increased is:
Respuesta
-
a. acute intermittent porphyria
-
b. iron deficiency anemia
-
c. porphyria cutanea tarda
-
d. acute porphyric attack
Pregunta 23
Pregunta
The stimulant that causes localized sweating for the sweat test is:
Respuesta
-
a. polyvinyl alcohol
-
b. lithium sulfate
-
c. potassium sulfate
-
d. pilocarpine nitrate
Pregunta 24
Pregunta
In the sweat test, the sweating stimulant is introduced to the skin by application of:
Pregunta 25
Pregunta
The formula for calculating serum osmolality that incorporates a correction for the water content of plasma is:
Respuesta
-
a. 2 Na x (GlucoseI2O) x (BUN/3) ½
-
b. Na + [(2 x Glucose)/20] x (BUN/3)
-
c. 2 Na + Glucose/20 + (BUN/3)
-
d. 2 Na + Glucose/3 + (BUN/20)
Pregunta 26
Pregunta
Osmolal gap is the difference between:
Respuesta
-
a. ideal and real osmolality values
-
b. calculated and measured osmolality values
-
c. plasma and water osmolality values
-
d. molality and molarity at 40C
Pregunta 27
Pregunta
Erroneous ammonia levels can be eliminated by all of the following EXCEPT:
Respuesta
-
a. ensuring water and reagents are ammonia-free
-
b. separating plasma from cells and performing test analysis as soon as possible
-
c. drawing the specimen in a pre-chilled tube and immersing the tube in ice
-
d. storing the specimen protected from light until the analysis is done
Pregunta 28
Pregunta
Which of the following applies to cryoscopic osmometry?
Respuesta
-
a. temperature at equilibrium is a function of the number of particles in solution.
-
b. temperature plateau for a solution is horizontal.
-
c. freezing point of a sample is absolute.
-
d. initial freezing of a sample produces an immediate solid state.
Pregunta 29
Pregunta
The first step to be taken when attempting to repair a piece of electronic equipment is:
Respuesta
-
a. check all the electronic connections
-
b. reseat all the printed circuit boards
-
c. turn the instrument off
-
d. replace all the fuses
Pregunta 30
Pregunta
Most of the carbon dioxide present in blood is in the form of:
Respuesta
-
a. dissolved C02
-
b. carbonate
-
c. bicarbonate ion
-
d. carbonic acid
Pregunta 31
Pregunta
The degree to which the kidney concentrates the glomerular filtrate can be determined by:
Pregunta 32
Pregunta
How many grams of sulfosalicylic acid (MW = 254) are required to prepare 1 L of a 3% (w/v) solution?
Pregunta 33
Pregunta
A physician suspects his patient has pancreatitis. Which test(s) would be most indicative of this disease?
Respuesta
-
creatinine
-
LD isoenzymes
-
hydroxybutyrate
-
amylase
Pregunta 34
Pregunta
The statistical term for the average value is the:
Respuesta
-
mode
-
median
-
mean
-
coefficient of variation
Pregunta 35
Pregunta
An index of precision is statistically known as the:
Respuesta
-
median
-
mean
-
standard deviation
-
coefficient of variation
Pregunta 36
Pregunta
The most frequent value in a collection of data is statistically known as the:
Respuesta
-
mode
-
median
-
mean
-
standard deviation
Pregunta 37
Pregunta
The middle value of a data set is statistically known as the:
Respuesta
-
mean
-
median
-
mode
-
standard deviation
Pregunta 38
Pregunta
In a specimen collected for plasma glucose analysis, sodium fluoride:
Pregunta 39
Pregunta
In the international system of units serum urea is expressed in millimoles per liter. A serum urea nitrogen concentration of 28 mg/dL would be equivalent to what concentration of urea?
(Urea: NH2CONH2; atomic wt N = 14, C = 12, 0= 16, H = 1)
Respuesta
-
4.7mEqIL
-
5.0mEqIL
-
10.0mEqIL
-
20.0 mEqIL
Pregunta 40
Pregunta
The osmolal gap is defined as measured Osm/kg minus the calculated Osm/kg. The average osmolal gap is near:
Pregunta 41
Pregunta
To be analyzed by gas liquid chromatography, a compound must:
Pregunta 42
Pregunta
The solute that contributes the most to the total serum osmolality is:
Respuesta
-
glucose
-
sodium
-
chloride
-
urea
Pregunta 43
Pregunta
In automated methods utilizing a bichromatic analyzer, dual wavelengths are employed to:
Pregunta 44
Pregunta
Which of the following electrodes is based on the principle of amperometric measurement?
Pregunta 45
Pregunta
One international unit of enzyme activity is the amount of enzyme that, under specified reaction conditions of substrate concentration, pH, and temperature, causes utilization of substrate at the rate of:
Respuesta
-
1 mole/min
-
1 millimole/min
-
1 micromole/min
-
1 nanomole/min
Pregunta 46
Pregunta
The Porter-Silber method (phenylhydrazine in alcohol and sulfuric acid) involves which part of the steroid molecule?
Pregunta 47
Pregunta
Which family of steroid hormones is characterized by an unsaturated A ring?
Respuesta
-
progestins
-
estrogens
-
androgens
-
glucocorticoids
Pregunta 48
Pregunta
Which of the following statements about immunoassays using enzyme-labeled antibodies or antigens is correct?
Respuesta
-
Inactivation of the enzyme is required.
-
The enzyme label is less stable than an isotopic label.
-
Quantitation of the label can be carried out with a spectrophotometer.
-
The enzyme label is not an enzyme found naturally in serum.
Pregunta 49
Pregunta
Which of the following chemical determinations may be of help in establishing the presence of seminal fluid?
Pregunta 50
Pregunta
Which of the following serum protein fractions is most likely to be elevated in patients with nephrotic syndrome?
Respuesta
-
alpha-I globulin
-
alpha-I globulin and alpha-2 globulin
-
alpha-2 globulin and beta globulin
-
beta globulin and gamma globulin
Pregunta 51
Pregunta
Which of the following enzyme substrates for prostatic acid phosphatase results in the highest specificity?
Pregunta 52
Pregunta
The following laboratory results were obtained on arterial blood:
Sodium l36mEq/L
pH 7.32
Potassium 4.4 mEq/L
PCO~ 79 mm Hg
Chloride 92 mEq/L
Bicarbonate 40 mEq/L
These results are most compatible with:
Respuesta
-
a. respiratory alkalosis
-
b. respiratory acidosis
-
c. metabolic alkalosis
-
d. metabolic acidosis
Pregunta 53
Pregunta
Increased total serum lactic dehydrogenase activity, confined to fractions 4 and 5, is most likely associated with:
Respuesta
-
a. pulmonary infarction
-
b. hemolytic anemia
-
c. myocardial infarction
-
d. acute viral hepatitis
Pregunta 54
Pregunta
Regan isoenzyme has the same properties as alkaline phosphatase that originates in the:
Respuesta
-
skeleton
-
kidney
-
intestine
-
placenta
Pregunta 55
Pregunta
Assay of transketolase activity in blood is used to detect deficiency OL
Respuesta
-
thiamine
-
b. folic acid
-
c. ascorbic acid
-
d. riboflavin
Pregunta 56
Pregunta
The substance that is measured to estimate the serum concentration of triglycerides by MOST methods is:
Respuesta
-
a. phospholipids
-
b. glycerol
-
c. fatty acids
-
d. pre-beta lipoprotein
Pregunta 57
Pregunta
The most Sensitive enzymatic indicator for liver damage from ethanol intake is:
Respuesta
-
a. alanine aminotransferase (ALT)
-
b. aspartate aminotransferase (AST)
-
c. gamma-glutamyl transferase (GGT)
-
d. alkaline phosphatase
Pregunta 58
Pregunta
Refer to the following illustration:
Patient Values Reference Values
Total Protein 7.3 g/dL 6.0-8.0 g/dL
Albumin 4.2 g/dL 3.6-5.2 g/dL
Alpha-1 0.0 g/dL 0.1-0.4 g/dL
Alpha-2 0.9 g/dL 0.4-1.0 g/dL
Beta 0.8 g/dL 0.5-1.2 g/dL
Gamma 1.4g/dL 0.6-1.6g/dL
This electrophoresis pattern is consistent with:
Respuesta
-
cirrhosis
-
b. monoclonal gammopathy
-
c. polyclonal gammopathy (eg, chronic inflammation)
-
d. alpha-l antitrypsin deficiency; severe emphysema
Pregunta 59
Pregunta
Patients with Cushing's syndrome exhibit:
Respuesta
-
a. decreased plasma 17-hydroxysteroid concentration
-
b. decreased urinary 17-hydroxysteroid excretion
-
c. serum cortisol concentrations greater than 15 mg/dL
-
d. decreased cortisol secretory rate
Pregunta 60
Pregunta
60. A one molal solution is equivalent to:
Respuesta
-
a. a solution containing one mole of solute per kg of solvent
-
b. 1000 mL of solution containing one mole of solute
-
c. a solution containing one gram-equivalent weight of solute in one liter of solution
-
d. a 1-L solution containing 2 moles of solute
Pregunta 61
Pregunta
Refer to the following illustration:
Patient Values Reference Values
Total Protein 8.9 g/dL 6.0-8.0 g,dL
Albumin 4.8 g/dL 3.6-5.2 g/dL
Alpha-1 0.3 g/dL 0.1-0.4 g/dL
Alpha-2 0.7 g/dL 0.4-1.0 g/dL
Beta 0.8 g/dL 0.5-1.2 g/dL
Gamma 2.3 g/dL 0.6-1.6 g/dL
The serum protein electrophoresis pattern is consistent with:
Pregunta 62
Pregunta
Refer to the following pattern:
Patient Values Reference Values
Total Protein 6.1g/dL 6.0-8.0g/dL
Albumin 2.3 g/dL 3-5.2 g/dL
Alpha-1 0.2 g/dL 0.1-0.4 g/dL
Alpha-2 0.5 g/dL 0-1.0 g/dL
Beta 1.2g/dL 0.5-l.2g/dL
Gamma l.9g/dL 0-1.6g/dL
This pattern is consistent with:
Respuesta
-
a. cirrhosis
-
b. acute inflammation
-
c. polyclonal gammopathy (eg, chronic inflammation)
-
d. alpha-1 antitrypsin deficiency; severe emphysema
Pregunta 63
Pregunta
63. Given the following results:
Alkaline phosphatase Slight increase
Alanine transferase. Marked increase
Aspartate transferase Marked increase
Gamma-glutamyl transferase. Slight increase
This is most consistent with:
Respuesta
-
a. acute hepatitis
-
b. chronic hepatitis
-
c. obstructive jaundice
-
d. liver hemangioma
Pregunta 64
Pregunta
Given the following results:
Alkaline phosphatase Marked increase
Alanine transferase Slight increase
Aspartate aminotransferase Slight increase
Gamma-glutamyl transferase Marked increase
This is most consistent with:
Respuesta
-
a. acute hepatitis
-
b. osteitis fibrosa
-
c. chronic hepatitis
-
d. obstructive jaundice
Pregunta 65
Pregunta
Given the following results:
Alkaline phosphatase Slight increase
Alanine transferase Slight increase
Aspartate aminotransferase Slight increase
Gamma-glutamyl transferase Slight increase
This is most consistent with:
Respuesta
-
a. acute hepatitis
-
b. chronic hepatitis
-
c. obstructive jaundice
-
d. liver hemangioma
Pregunta 66
Pregunta
66. Which of the following statements about fluorometry are true?
Respuesta
-
a. A compound is said to fluoresce when it absorbs light at one wavelength and emits light at a second wavelength.
-
b. Detectors in fluorometers are placed 1800 from the excitation source.
-
c. It is less sensitive than spectrophotometry.
-
d. It avoids the necessity for complexing of components because fluorescence is a native property.
Pregunta 67
Pregunta
A benefit of microassays includes:
Respuesta
-
a. increased analytical reliability
-
b. reduced reagent requirements
-
c. increased diagnostic specificity
-
d. reduced numbers of repeated tests
Pregunta 68
Pregunta
Refer to the following illustration:
This illustration represents the change in absorbance at 340 nm over a period of 8 minutes in an assay for lactate dehydrogenase. True statements about this figure include:
Respuesta
-
The reaction follows zero order kinetics between 5 and 8 minutes.
-
The reaction is proceeding from lactate to pyruvate.
-
Non-linearity after 6 minutes is due to substrate exhaustion
-
The change in absorbance is due to reduction of NAD to NADH.
Pregunta 69
Pregunta
A serum sample drawn in the emergency room from a 42-year-old man yielded the follow¬ing laboratory results:
CK 185 Units (Normal = 15-160)
AST 123 Units (Normal = 0-48)
CK-MB 6 Units (Normal = 2-12)
Which of the following conditions might account for these values?
Pregunta 70
Pregunta
In competitive inhibition of an enzyme reaction the:
Respuesta
-
inhibitor binds to the enzyme at the same site as the substrate
-
inhibitor often has a chemical structure different from that of the substrate
-
activity of the reaction can be decreased by increasing the concentration of the substrate
-
activity of the reaction can be increased by decreasing the temperature
Pregunta 71
Pregunta
Kernicterus is an abnormal accumulation of bilirubin in:
Respuesta
-
heart tissue
-
brain tissue
-
liver tissue
-
kidney tissue
Pregunta 72
Pregunta
Two standard deviations is the acceptable limit of error in the chemistry laboratory. If you run the normal control 100 times, how many of the values would be out of control due to random error?
Pregunta 73
Pregunta
Serum haptoglobin:
Respuesta
-
is decreased in patients with tissue injury and neoplasia
-
is increased in patients with prosthetic heart valves
-
can be separated into distinct phenotypes by starch-gel electrophoresis
-
binds heme
Pregunta 74
Pregunta
Which of the following serum proteins migrates with the beta-globulins on cellulose acetate at pH 8.6?
Pregunta 75
Pregunta
Fasting serum phosphate concentration is controlled primarily by the:
Respuesta
-
pancreas
-
skeleton
-
parathyroid glands
-
small intestine
Pregunta 76
Pregunta
Serum “anion gap" is increased in patients with:
Pregunta 77
Pregunta
Increased serum lactic dehydrogenase activity due to elevation of fast fraction (1 and 2) on electrophoretic separation is caused by:
Respuesta
-
nephrotic syndrome
-
hemolytic
-
pancreatitis
-
hepatic damage
Pregunta 78
Pregunta
The nanometer is used as a measure of:
Pregunta 79
Pregunta
Major actions of angiotensin II include:
Respuesta
-
a. increased pituitary secretion of renin
-
b. increased vasoconstriction
-
c. increased parathyroid hormone secretion by the parathyroid
-
d. decreased adrenal secretion of aldosterone
Pregunta 80
Pregunta
The presence of increased CK- MB activity on a CK electrophoresis pattern is most likely found in a patient suffering from:
Pregunta 81
Pregunta
What is the molarity of a solution that contains 18.7 g of KCl (MW 74.5) in 500 mL of water?
Pregunta 82
Pregunta
In the total bilirubin assay, bilirubin reacts with diazotized sulfanilic acid to form:
Respuesta
-
diazo bilirubin
-
biliverdin
-
azobilirubin
-
bilirubin glucuronide
Pregunta 83
Pregunta
Total glycosylated hemoglobin levels in a hemolysate reflect the:
Respuesta
-
a. average blood glucose levels of the past 2-3 months
-
b. average blood glucose levels for the past week
-
c. blood glucose level at the time the sample is drawn
-
d. hemoglobin A1C level at the time the sample is drawn
Pregunta 84
Pregunta
The identification of Bence Jones protein is best accomplished by:
Pregunta 85
Pregunta
The anion gap is useful for quality control of laboratory results for:
Respuesta
-
a. amino acids and proteins
-
b. blood gas analyses
-
c. sodium, potassium, chloride, and total C02
-
d. calcium, phosphorus, and magnesium
Pregunta 86
Pregunta
Which percentage of total serum calcium is nondiffusible protein bound?
Respuesta
-
a. 80%-90%
-
b. 51%-60%
-
c. 40%-50%
-
d. 10%-30%
Pregunta 87
Pregunta
The buffering capacity of blood is maintained by a reversible exchange process between bicarbonate and:
Respuesta
-
Sodium
-
potassium
-
calcium
-
chloride
Pregunta 88
Pregunta
Which of the following electrolytes is the chief plasma cation whose main function is main¬taining osmotic pressure?
Respuesta
-
Chloride
-
calcium
-
potassium
-
sodium
Pregunta 89
Pregunta
A reciprocal relationship exists between:
Respuesta
-
sodium and potassium
-
calcium and phosphorus
-
chloride and C02
-
calcium and magnesium
Pregunta 90
Pregunta
An assay calls for 0.1 mL serum, 5 mL of reagent and 4.9 mL of water. What is the serum dilution in the final solution?
Pregunta 91
Pregunta
At blood pH 7.40 what is the ratio between bicarbonate and carbonic acid?
Pregunta 92
Pregunta
The bicarbonate and carbonic acid ratio is calculated from an equation by:
Respuesta
-
a. Siggaard-Andersen
-
b. Gibbs-Donnan
-
c. Natelson
-
d. Henderson-Hasselbaich
Pregunta 93
Pregunta
Acidosis and alkalosis are best defined as fluctuations in blood pH and C02 content due to changes in:
Respuesta
-
a. Bohr's effect
-
b. 02 content
-
c. bicarbonate buffer
-
d. carbonic anhydrase
Pregunta 94
Pregunta
A common cause of respiratory alkalosis is:
Respuesta
-
a. vomiting
-
b. starvation
-
c. asthma
-
d. hyperventilation
Pregunta 95
Pregunta
Metabolic acidosis is described as a(n):
Respuesta
-
a. increase in CO2 content and PCO2 with a decreased pH
-
b. decrease in CO2 content with an increased pH
-
c. increase in CO2 with an increased pH
-
d. decrease in CO2 content and PCO2 with a decreased pH
Pregunta 96
Pregunta
Respiratory acidosis is described as a(n):
Respuesta
-
a. increase in CO2 content and PCO2 with a decreased pH
-
b. decrease in CO2 content with an increased pH
-
c. increase in CO2 content with an increased pH
-
d. decrease in CO2 content and PCO2 with a decreased pH
Pregunta 97
Pregunta
With a bicarbonate of 24 mEq/L and a carbonic acid of 1.2 mEq/L, calculate the pH
Pregunta 98
Pregunta
The normal range for the pH of arterial blood measured at 37ºC is:
Respuesta
-
a. 7.28-7.34
-
b. 7.33-7.37
-
c. 7.35-7.45
-
d. 7.45-7.50
Pregunta 99
Pregunta
Unless blood gas measurements are made immediately after sampling, in vitro glycolysis of the blood causes a:
Respuesta
-
a. rise in pH and PCO2
-
b. fall in pH and a rise in P02
-
c. rise in pH and fall in P02
-
d. fall in pH and a rise in PCO2
Pregunta 100
Pregunta
Hydrogen ion concentration (pH) in blood is usually determined by means of which of the following electrodes?
Respuesta
-
Silver
-
glass
-
platinum
-
platinum-lactate
Pregunta 101
Pregunta
In the immunoinhibition phase of the CK-MB procedure:
Pregunta 102
Pregunta
The conversion of glucose or other hexoses into lactate or pyruvate is called:
Respuesta
-
a. glycogenesis
-
b. glycogenolysis
-
c. gluconeogenesis
-
d. glycolysis
Pregunta 103
Pregunta
Different water content of erythrocytes and plasma makes true glucose concentrations in whole blood a function of :
Respuesta
-
a. hematocrit
-
b. leukocyte count
-
c. erythrocyte count
-
d. erythrocyte indices
Pregunta 104
Pregunta
In the fasting state, arterial and capillary blood glucose varies from the venous glucose by how many mg/dL?
Respuesta
-
a. 2 mg/dL higher
-
b. 5 mg/dL higher
-
c. 10mg/dL lower
-
d. 12mg/dL lower
Pregunta 105
Pregunta
Which of the following hemoglobins has glucose-6-phosphate on the amino-terminal valine of the beta chain?
Pregunta 106
Pregunta
Increased concentrations of ascorbic acid inhibit chromogen production in which of the fol¬lowing glucose methods?
Pregunta 107
Pregunta
The function of the major lipid components of the very low density lipoproteins (VLDL) js to transport:
Respuesta
-
a. cholesterol from peripheral cells to the liver
-
b. cholesterol and phospholipids to peripheral cells
-
c. exogenous triglycerides
-
d. endogenous triglycerides
Pregunta 108
Pregunta
The most widely used support medium for electrophoretic separation of lipoproteins is:
Respuesta
-
a. agar gel
-
b. starch gel
-
c. paper
-
d. agarose gel
Pregunta 109
Pregunta
A hospitalized patient is experiencing tetany. Which test should be ordered immediately?
Respuesta
-
a. calcium
-
b. phosphorus
-
c. BUN
-
d. glucose
Pregunta 110
Pregunta
Analysis of CSF for oligoclonal bands is used to screen for which of the following disease states?
Pregunta 111
Pregunta
Sixty to seventy-five percent of the plasma cholesterol is transported by:
Respuesta
-
a. chylomicrons
-
b. very low density lipoprotein
-
c. low density lipoprotein
-
d. high density lipoprotein
Pregunta 112
Pregunta
The major fraction of organic iodine in the circulation is in the form of:
Respuesta
-
a. thyroglobulin
-
b. thyroxine
-
c. triiodothyronine
-
d. diiodotyrosine
Pregunta 113
Pregunta
Measurement of total T4 by competitive protein binding or displacement is based on specific binding properties of:
Respuesta
-
a. thyroxine-binding prealbumin
-
b. albumin
-
c. thyroxine-binding globulin
-
d. thyroid-stimulating hormone
Pregunta 114
Pregunta
Which of the following methods employs a highly specific antibody to thyroxine?
Pregunta 115
Pregunta
A mean value of 100 and a standard deviation of 1.8 mg/dL were obtained from a set of glucose measurements on a control solution. The 95% confidence interval in mg/dL would be:
Respuesta
-
a. 94.6-105.4
-
b. 96.4-103.6
-
c. 97.3-102.7
-
d. 98.2-101.8
Pregunta 116
Pregunta
The extent to which measurements agree with the true value of the quantity being measured is known as:
Respuesta
-
a. reliability
-
b. accuracy
-
c. reproducibility
-
d. precision
Pregunta 117
Pregunta
When myocardial infarction occurs, the first enzyme to become elevated is:
Pregunta 118
Pregunta
In the assay of lactate dehydrogenase at 340 nm, using pyruvate as the substrate, one actually measures a:
Respuesta
-
a. decrease in pyruvate
-
b. decrease in NADH
-
c. increase in lactate
-
d. increase in NADH
Pregunta 119
Pregunta
In the Jaffe reaction, creatinine reacts with:
Respuesta
-
a. alkaline sulfasalazine solution to produce an orange-yellow complex
-
b. potassium iodide to form a reddish-purple complex
-
c. sodium nitroferricyanide to yield a reddish-brown color
-
d. alkaline picrate solution to yield an orange-red complex
Pregunta 120
Pregunta
Which of the following represents the end product of purine metabolism in humans?
Respuesta
-
a. AMP and GMP
-
b. DNA and RNA
-
c. allantoin
-
d. uric acid
Pregunta 121
Pregunta
In protein electrophoresis where the sample is placed in an electric field with a buffer of pH 8.6, all of the proteins:
Respuesta
-
a. have a positive charge
-
b. have a negative charge
-
c. are electrically neutral
-
d. migrate toward the cathode
Pregunta 122
Pregunta
Maple syrup urine disease is characterized by an increase in which of the following urinary amino acids?
Pregunta 123
Pregunta
The hemoglobin that is resistant to alkali (KOH) denaturation is:
Pregunta 124
Pregunta
The parent substance in the biosynthesis of androgens and estrogens is:
Respuesta
-
a. cortisol
-
b. catecholamines
-
c. progesterone
-
d. cholesterol
Pregunta 125
Pregunta
The biologically most active, naturally occurring androgen is:
Pregunta 126
Pregunta
A 24-hour urine specimen (total volume = 1136 m) is submitted to the laboratory for quantitative urine protein. Calculate the amount of protein excreted per day, if the total protein is 52 mg/dL.
Respuesta
-
a. 591 mg
-
b. 487 mg
-
c. 220mg
-
d. 282 mg
Pregunta 127
Pregunta
Which of the following is secreted by the placenta and used for the early detection of pregnancy?
Respuesta
-
a. follicle-stimulating hormone (FSH)
-
b. human chorionic gonadotropin (HCG)
-
c. luteinizing hormone (LH)
-
d. progesterone
Pregunta 128
Pregunta
Decreased serum iron associated with increased TIBC is compatible with which of the following disease states?
Pregunta 129
Pregunta
A characteristic of the Bence Jones protein that is used to distinguish it from other urinary proteins is its solubility:
Respuesta
-
a. in ammonium sulfate
-
b. in sulfuric acid
-
c. at 40ºC-60ºC
-
d. at 100ºC
Pregunta 130
Pregunta
130. Which of the following is an example of a peptide bond?
Pregunta 131
Pregunta
The principal excretory form of nitrogen is:
Respuesta
-
a. ammo acids
-
b. creatinine
-
c. urea
-
d. uric acid
Pregunta 132
Pregunta
A 45-year-old male of average height / weight was admitted for renal function studies with the following lab results:
Urine creafinine 120 mgidL
Serum creafinine 1.5 mg/dL
Total urine volume in 24 hours 1 800/niL
Calculate the creatinine clearance for this patient in mL/min.
Pregunta 133
Pregunta
In the determination of bilirubin. the reagent that is reacted with bilirubin to form azobilirubin is:
Pregunta 134
Pregunta
Bile acid concentrations are useful to assess:
Pregunta 135
Pregunta
Which of the following enzymes catalyzes the conversion of starch to glucose and maltose?
Pregunta 136
Pregunta
A scanning of a CK isoenzyme fractionation revealed two peaks: a slow cathodic peak (CK-MM) and an intermediate peak (CK-MB). A possible interpretation for this pattern is:
Respuesta
-
a. brain tumor
-
b. muscular dystrophy
-
c. myocardial infarction
-
d. viral hepatitis
Pregunta 137
Pregunta
Which of the following enzymes are used in the diagnosis of acute pancreatitis?
Respuesta
-
a. amylase and lipase
-
b. aspartate transferase and alanine transferase
-
c. 5'-nucleotidase and gamma-glutamyl transferase
-
d. aspartate aminotransferase and lactate dehydrogenase
Pregunta 138
Pregunta
Which of the following is a glycolytic enzyme that catalyzes the cleavage of fructose-1,
6-diphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate?
Pregunta 139
Pregunta
The greatest activities of serum AST and ALT are seen in:
Pregunta 140
Pregunta
An electrophoretic separation of lactate dehydrogenase isoenzymes that demonstrates an elevation in LD-1 and LD-2 in a “flipped" pattern is consistent with:
Respuesta
-
a. myocardial infarction
-
b. viral hepatitis
-
c. pancreatitis
-
d. renal failure
Pregunta 141
Pregunta
Which of the following is a characteristic shared by lactate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, and hydroxybutyrate dehydrogenase?
Respuesta
-
a. They are liver enzymes.
-
b. They are cardiac enzymes.
-
c. They catalyze oxidation-reduction reactions.
-
d. They are class III enzymes.
Pregunta 142
Pregunta
The protein portion of an enzyme complex is called the:
Respuesta
-
a. apoenzyme
-
b. coenzyme
-
c. holoenzyme
-
d. proenzyme
Pregunta 143
Pregunta
The most heat labile fraction of alkaline phosphatase is obtained from:
Respuesta
-
liver
-
bone
-
intestine
-
placenta
Pregunta 144
Pregunta
Refer to the following illustration:
Which of the following is the most likely interpretation of the LD isoenzyme scan illustrated above?
Respuesta
-
a. myocardial infarction
-
b. megaloblastic anemia
-
c. acute pancreatitis
-
d. viral hepatitis
Pregunta 145
Pregunta
Blood specimens for digoxin assays should be obtained between 8 hours or more after drug administration because:
Respuesta
-
a. tissue and serum levels need to reach equilibrium
-
b. serum digoxin concentration will be falsely low prior to 6 hours
-
c. all of the digoxin is in the cellular fraction prior to 6 hours
-
d. digoxin protein-binding interactions are minimal prior to 6 hours
Pregunta 146
Pregunta
Bioavailability of a drug refers to the:
Respuesta
-
a. availability for therapeutic administration
-
b. availability of the protein-bound fraction of the drug
-
c. drug transformation
-
d. the fraction of the drug absorbed into the systemic circulation
Pregunta 147
Pregunta
The cyclic antidepressants are classified as:
Pregunta 148
Pregunta
Zinc protoporphyrin or free erythrocyte protoporphyrin measurements are useful to assess blood concentrations of:
Respuesta
-
lead
-
mercury
-
arsenic
-
beryllium
Pregunta 149
Pregunta
Gas chromatography with a nitrogen/phosphorus detector is the most commonly used technique for analysis of:
Respuesta
-
digoxin
-
acetylsalicylic acid
-
ethyl alcohol
-
cyclic antidepressants
Pregunta 150
Pregunta
The most widely employed screening technique for drug abuse is:
Respuesta
-
a. high-performance liquid chromatography
-
b. gas-liquid chromatography
-
c. thin layer chromatography
-
d. UV spectrophotometry
Pregunta 151
Pregunta
Malic dehydrogenase is added to the aspartate transaminase reaction to catalyze the conversion of:
Respuesta
-
a. alpha-ketoglutarate to aspartate
-
b. alpha-ketoglutarate to malate
-
c. aspartate to oxalacetate
-
d. oxalacetate to malate
Pregunta 152
Pregunta
Phenobarbital is a metabolite of:
Respuesta
-
a. primidone
-
b. phenytoin
-
c. amobarbital
-
d. secobarbital
Pregunta 153
Pregunta
Increased serum albumin concentrations are seen in which of the following conditions?
Respuesta
-
a. nephrotic syndrome
-
b. acute hepatitis
-
c. chronic inflammation
-
d. dehydration
Pregunta 154
Pregunta
Which of the following amino acids is associated with a sulfhydryl group?
Respuesta
-
cysteine
-
glycine
-
serine
-
tyrosine
Pregunta 155
Pregunta
Beriberi is associated with deficiency of:
Respuesta
-
a. vitamin A
-
b. vitamin C
-
c. niacin
-
d. thiamine
Pregunta 156
Pregunta
Night blindness is associated with deficiency of which of the following vitamins?
Pregunta 157
Pregunta
Scurvy is associated with deficiency of which of the following vitamins?
Pregunta 158
Pregunta
Pellagra is associated with deficiency of which of the following vitamins?
Pregunta 159
Pregunta
Rickets is associated with deficiency of which of the following vitamins?
Pregunta 160
Pregunta
The regulation of calcium and phosphorus metabolism is accomplished by which of the following glands?
Respuesta
-
a. thyroid
-
b parathyroid
-
c. adrenal glands
-
d. pituitary
Pregunta 161
Pregunta
Lithium therapy is widely used in the treatment of:
Respuesta
-
a. hypertension
-
b. hyperactivity
-
c. aggression
-
d. manic-depression
Pregunta 162
Pregunta
The anticonvulsant used to control tonic-clonic (grand mal) seizures is:
Respuesta
-
a. digoxin
-
b. acetaminophen
-
c. lithium
-
d. phenytoin
Pregunta 163
Pregunta
A drug that relaxes the smooth muscles of the bronchial passages is:
Respuesta
-
acetaminophen
-
lithium
-
phenytoin
-
theophylline
Pregunta 164
Pregunta
A cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of myocardial contraction is:
Respuesta
-
digoxin
-
acetaminophen
-
lithium
-
phenytoin
Pregunta 165
Pregunta
A carbonate salt used to control manic-depressive disorders is:
Respuesta
-
digoxin
-
acetaminophen
-
lithium
-
phenytoin
Pregunta 166
Pregunta
In which of the following disease states is conjugated bilirubin a major serum component?
Respuesta
-
biliary obstruction
-
hemolysis
-
neonatal jaundice
-
erythroblastosis fetalis
Pregunta 167
Pregunta
Spectrophotometers isolate a narrow band pass by means of:
Pregunta 168
Pregunta
Refer to the following illustration:
The serum protein electrophoresis pattern shown below was obtained on cellulose acetate at pH 8.6. Identify the serum protein fraction on the far right of the illustration.
Respuesta
-
gamma globulin
-
albumin
-
alpha-1 globulin
-
alpha-2 globulin
Pregunta 169
Pregunta
The creatinine clearance (mL/min) is equal to:
Respuesta
-
urinary creatinine (mg/L)/[volume of urine (mL/ruin) x plasma creatinine (mg/L)]
-
[urinary creatinine (mg/L) x volume (mL/min)]/plasma creatinine (mg/L)
-
urinary creatinine (mg/L)/[volume of urine (mL/hour) x plasma creatinine (mg/L)]
-
[urinary creatinine (mg/L) x volume (mL/hour)]/plasma creatinine (mg/L)
Pregunta 170
Pregunta
A solution contains 20 g of solute dissolved in 0.5 L of water. What is the percentage of this solution?
Pregunta 171
Pregunta
Which of the following is the formula for calculating the unknown concentration based on Beer’s law (A=absorbance C=concentration)?
Pregunta 172
Pregunta
Which of the following is the formula for calculating absorbance given the percent transmittance (%T) of a solution?
Respuesta
-
1 – log of %%
-
log of %T/2
-
2 x log of %T
-
2 – log of %T
Pregunta 173
Pregunta
Which of the following is the formula for calculating the amount of moles of a chemical?
Respuesta
-
g/GMW
-
g x GMW
-
GMW/g
-
(g x l00)/GMW
Pregunta 174
Pregunta
How many milliliters of a 3% solution can be made if 6 g of solute are available?
Respuesta
-
100 mL
-
200 mL
-
400 mL
-
600 mL
Pregunta 175
Pregunta
Which of the following is the formula for calculating the gram equivalent weight of a chemical?
Respuesta
-
a. MW x oxidation number
-
b. MW/oxidation number
-
c. MW + oxidation number
-
d. MW - oxidation number
Pregunta 176
Pregunta
Which of the following is the formula for calculating the dilution of a solution (V=volume, C=concentration)?
Respuesta
-
a. V1 + C1 = V2 + C2
-
b. V1 + C2 = V2 + C1
-
c. V1 x C1 = V2 x C2
-
d. V1 x V2 = -V1 x C2
Pregunta 177
Pregunta
Which of the following is the Henderson-Hasselbach equation?
Respuesta
-
a. pKa = pH + log(acid/salt)
-
b. pKa = pH + log(salt/acid)
-
c. pH = pKa + log(acid/salt)
-
d. pH = pKa + log(salt/acid)
Pregunta 178
Pregunta
Which of the following is the formula for calculating a percent (w/v) solution?
Respuesta
-
a. grams of solute/volume of solvent x 100
-
b. grams of solute x volume of solvent x 100
-
c. volume of solvent/grams of solute x 100
-
d. (grams of solute x volume of solvent)/100
Pregunta 179
Pregunta
Which of the following is the formula for coefficient of variation?
Respuesta
-
(standard deviation x 100)/standard error
-
(mean x 100)/standard deviation
-
(standard deviation x 100)/mean
-
(variance x 100)/mean
Pregunta 180
Pregunta
Given the following values:
100
120
150
140
130
What is the mean?
Respuesta
-
a. 100
-
b. 128
-
c. 130
-
d. 640
Pregunta 181
Pregunta
Which of the following is the formula for arithmetic mean?
Respuesta
-
a. square root of the sum of values
-
b. sum of values x number of values
-
c. number of values/sum of values
-
d. sum of values/number of values
Pregunta 182
Pregunta
Which of the following is the formula for calculating the molarity of a solution?
Respuesta
-
a. number of moles of solute/L of solution
-
b. number of moles of solute x 100
-
c. 1 GEW of solute x 10
-
d. I GEW of solute/L of solution
Pregunta 183
Pregunta
The following results were obtained:
Urine creatiinine 90 mg/100 mL
Serum creatinine 0.90 mg/100 mL
Patient's total body surface 1.73 m2 (average = 1.73 m2)
Total urine volume in 24 hours 1500 mL
Given the above data, calculate the patient's creatinine clearance in ni/mm.
Respuesta
-
a. 104
-
b. 124
-
c. 144
-
d. 150
Pregunta 184
Pregunta
25 g of NaOH (MW = 40) is added to 0.5 L of water. What is the molarity of this solution if an additional 0.25 L of water is added to this solution?
Respuesta
-
a. 0.25 M
-
b. 0.50 M
-
c. 0.75 M
-
d. 0.83 M
Pregunta 185
Pregunta
4 mL of water is added to 1 mL of serum. This represents which of the following serum dilutions?
Respuesta
-
a. 1:3
-
b. 1:4
-
c. 1:5
-
d. 1:6
Pregunta 186
Pregunta
80 g of NaOH (MW = 40) is how many gram-equivalents?
Pregunta 187
Pregunta
How many grams of H2S04 (MW = 98) are in 750 mL of 3 N H2SO4
Respuesta
-
a. 36 g
-
b. 72 g
-
c. 110 g
-
d. 146g
Pregunta 188
Pregunta
what is the normality of a solution that contains 280 g of NaOH (MW = 40) in 2000 mL of solution?
Respuesta
-
a. 3.5N
-
b. 5.5N
-
c. 7.0N
-
d. 8.0N
Pregunta 189
Pregunta
A serum potassium is 19.5 mg/l00 mL. This value is equal to how many mEq/L (MW of K=39)?
Respuesta
-
a. 3.9
-
b. 4.2
-
c. 5.0
-
d. 8.9
Pregunta 190
Pregunta
How many milliliters of 0.25 N NaOH are needed to make 100 mL of a 0.05 N solution of NaOH?
Respuesta
-
a. 5 mL
-
b. 10 mL
-
c. 15 mL
-
d. 20 mL
Pregunta 191
Pregunta
An arterial blood specimen submitted for blood gas analysis was obtained at 8:30 AM but was not received in the laboratory until 11:00 AM. The technologist should:
Respuesta
-
a. perform the test immediately upon receipt
-
b. perform the test only if the specimen was submitted in ice water
-
c. request a venous blood specimen
-
d. request a new arterial specimen be obtained
Pregunta 192
Pregunta
A potassium level of 6.8 Eq/L is obtained. Before reporting the results, the first step the technologist should take is to:
Respuesta
-
a. check the serum for hemolysis
-
b. rerun the test
-
c. check the age of the patient
-
d. do nothing, simply report the result
Pregunta 193
Pregunta
Specimens for blood gas determination should be drawn into a syringe containing:
Respuesta
-
a. no preservative
-
b. heparin
-
c. EDTA
-
d. oxalate
Pregunta 194
Pregunta
A patient has the following test results:
Increased serum calcium levels
Decreased serum phosphorus levels
Increased levels of parathyroid hormone
This patient most likely has:
Respuesta
-
a. hyperparathyroidism
-
b. hypoparathyroidism
-
c. nephrosis
-
d. steatorrhea
Pregunta 195
Pregunta
If the total bilirubin is 4.3 mg/dL and the conjugated bilirubin is 2.1 mg/dL, the unconjugated bilirubin is:
Respuesta
-
1.1 mg/dL
-
2.2 mg/dL
-
4.2 mg/dL
-
6.3 mg/dL
Pregunta 196
Pregunta
The measurement of light scattered by particles in the sample is the principle of:
Respuesta
-
a. spectrophotometry
-
b. fluorometry
-
c. nephelometry
-
d. atomic absorption
Pregunta 197
Pregunta
The measurement of the amount of electricity passing between two electrodes in an electrochemical cell is the principle of:
Respuesta
-
a. electrophoresis
-
b. amperometry
-
c. nephelometry
-
d. coulometry
Pregunta 198
Pregunta
Coulometry is used to measure:
Respuesta
-
a. chloride
-
b. pH
-
c. bicarbonate
-
d. ammonia
Pregunta 199
Pregunta
Which of the following lipid results would be expected to be falsely elevated on a serum specimen from a nonfasting patient?
Respuesta
-
a. cholesterol
-
b. triglyceride
-
c. HDL
-
d. LDL
Pregunta 200
Pregunta
Turbidity in serum suggests elevation of:
Respuesta
-
a. cholesterol
-
b. total protein
-
c. chylomicrons
-
d. albumin