2812487
Descripción
Test por Alexandra McCabe, actualizado hace más de 1 año
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Creado por Alexandra McCabe
hace alrededor de 9 años
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Pregunta 1
Pregunta
What is the best way to assemble a genome?
Respuesta
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Have a reference gene to different species
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Have a reference gene to same species
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Have a reference genome to same species
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Have a reference genome to different species
Pregunta 2
Pregunta
Which is better DNA plat forms?
Respuesta
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Shorter reads cause of lower accurancy
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Longer reads easier to assemble
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Shorter reads cause of higher accurancy
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Longer reads harded to assemble
Pregunta 3
Pregunta
What happens next after you have fragments?
Respuesta
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Place contigs together to see where they fit on the reference genome
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Place contigs together next to eachother
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Analyse each contig
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Place contigs far apart
Pregunta 4
Pregunta
How do you increase the coverage for genome sequencing?
Respuesta
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Decrease the number of sequencing
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Increase the number of sequencing
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Use more DNA
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Use reference DNA
Pregunta 5
Pregunta
Sequence gap:
Respuesta
-
Don't have enough sequence but know the order and orientation of the contigs
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No information about the adjacent gap or spanning gap
Pregunta 6
Pregunta
Physical Gaps:
Respuesta
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No information about the adjacent gap or spanning gap
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Know the order and orientation of the contigs but dont have enough sequence
Pregunta 7
Pregunta
What is the function of genome scaffolds?
Respuesta
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Rearrange the genome
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Rearrange gene
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Construct and arrange contigs in relation to one another
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Place contigs on a stiff sufface
Pregunta 8
Pregunta
What step is after contig production when you are trying to build a gemone?
Respuesta
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Genome scaffolds with gaps in between contigs
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Join contigs using evidence from pair end data
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Place the contigs right next to eachother with no gaps
Pregunta 9
Pregunta
Why would you no fill the gap that is found between contigs on the genome scaffold?
Respuesta
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A customer might only want a scaffold of the genome
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Gaps can be over looked
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Customer might want to fill it in himself
Pregunta 10
Pregunta
What does N50 mean?
Respuesta
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The value of which 50% of nucleotides sequences are represented
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The percentage of gaps in the scaffold
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The number of genes produced
Pregunta 11
Pregunta
A k-mer are nucleotides that have been cut down to a certain size
Respuesta
- True
- False
Pregunta 12
Pregunta
What is the function of a contig?
Respuesta
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Represent a consensus region of DNA
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Represent the genome
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Represent the gene
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Represent a consensus region of RNA
Pregunta 13
Pregunta
How can you guess gap sizes on scaffold?
Respuesta
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Incorporating info from pair ends of the contigs
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Randomly guess
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Place all the contigs beneath each other
Pregunta 14
Pregunta
Long insert library
Respuesta
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4-40 kb library that has 100 bp on each end
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4-8 kb library that has 100 bp on each end
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4-40 kb library that has 10 bp on each end
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4-8 kb library that has 10 bp on each end
Pregunta 15
Pregunta
Why is De Novo genome assembly useful?
Respuesta
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Suitable for short coverage and long reads
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Suitable for long coverage and long reads
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Suitable for long coverage and short reads
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Suitable for short coverage and short reads
Pregunta 16
Pregunta
Why is the De Bruijn Graph useful?
Respuesta
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Suitable for high coverage and long reads
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Suitable for high coverage and short reads
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Suitable for short coverage and long reads
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Suitable for short coverage and short reads
Pregunta 17
Pregunta
How long do the k-mers need to be in overlap-layout-consensus?
Respuesta
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approx 24
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approx 2
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approx 240
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approx 2400
Pregunta 18
Pregunta
Why do the k mers in the De Bruijn model need to be similar sizes?
Respuesta
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If they are too small, it won't show overlaps
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If they are too long, it won't show overlaps
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If they are too small is easier to sequence
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If they are too long is easier to sequence
Pregunta 19
Pregunta
What is problem that arises when assembling fragments?
Respuesta
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Repeats
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mRNA
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cDNA
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gDNA
Pregunta 20
Pregunta
How do you solve the problem of repeats in genome assembly?
Respuesta
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Increase reading length which decreases sequence error rate
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Increase reading length which increases sequence error rate
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Decrease reading length which decreases sequence error rate
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Decrease reading length which increases sequence error rate
Pregunta 21
Pregunta
What takes up 45% of the genome?
Respuesta
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Large duplications
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Simple repeats
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Introns and Exons
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Transposons
Pregunta 22
Pregunta
Intergenic DNA have parasitic DNA that often fail to replicate properly
Respuesta
- True
- False
Pregunta 23
Pregunta
What is the name of the process whereby an exon from Gene A is placed in Gene B?
Respuesta
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Exon duplication
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Exon Shuffling
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Intron Duplication
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Intron Shuffling
Pregunta 24
Pregunta
What is the process whereby an exon is repeated and forms a new gene variant?
Respuesta
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Exon Duplication
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Exon Shuffling
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Intron Duplication
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Intron Shuffling
Pregunta 25
Pregunta
Entire gene families can be duplicated
Respuesta
- True
- False
Pregunta 26
Pregunta
What happens when entire gene super families get duplicated?
Respuesta
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Can double the number of copies of every gene and gene family
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Can half the number of copies of every gene and gene family
Pregunta 27
Pregunta
What happens when misaligned chromatids
Respuesta
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Repeats
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Transposons
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Exons
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Introns
Pregunta 28
Pregunta
Homologous genes in different organisms that encode proteins with the same function and have evolved by direct vertical descent
Respuesta
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Orthologous Genes
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Paralogous Genes
Pregunta 29
Pregunta
Homologous genes within an organism encoding proteins with related functions and often arise due to gene duplication
Respuesta
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Orthologous genes
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Paralogous genes
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