Pregunta 1
Pregunta
Loss of WT-1 gene results in what cancer?
Respuesta
-
Neuroblastoma
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Wilms tumor
Pregunta 2
Pregunta
All of the following are Autosomal recessive cancer predisposition disorders except?
Pregunta 3
Pregunta
All of the following are features of fanconi anemia except
Pregunta 4
Pregunta
Glioblastoma multiforme is due to 100x expression of an miRNA true or false?
Pregunta 5
Pregunta
Translocation in Burkitt's lymphoma
Respuesta
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8:14
-
9:22
-
11:22
-
none of the above
Pregunta 6
Pregunta
All of the following are true statements except
Respuesta
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Kaposis sarcoma caused by HHV-8
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Non-Hodgkin lymphoma - EBV
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Cervical cancer - HPV
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T-Cell leukemia - HTLV-I retrovirus
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CML - HPV
Pregunta 7
Pregunta
HPV oncogenes E6 & E7 act by?
Pregunta 8
Pregunta
In which cells telomeres are renewed (by activation of telomerase)?
Respuesta
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Germ cells
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cancer cells
-
all of the above
-
None of the above
Pregunta 9
Pregunta
Replicative senescence is due to the absence of telomerase - true or false
Pregunta 10
Pregunta
TERC : reverse transcriptase and TERT : RNA template true or false
Pregunta 11
Pregunta
Upregulation of what gene upregulates telomerase
Pregunta 12
Pregunta
Telomerase reactivation in cancer is the initiating event true or false
Pregunta 13
Pregunta
Telomerase reactivation in cancer is an important step in cancer progression true or false
Pregunta 14
Pregunta
Which of the following receptors belong to RTK family (receptor tyrosine kinases)
Respuesta
-
GFR
-
Insulin receptor
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both
-
none of the above
Pregunta 15
Pregunta
Activated RTKs phosphorylate what effector proteins?
Respuesta
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PLC
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PI3K
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both PLC PI3K
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Adenylate cyclase
Pregunta 16
Pregunta
RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false
Pregunta 17
Pregunta
Her2/EGFR2 genes are amplified in 30% breast cancers true or false
Pregunta 18
Pregunta
RAS-Gap gene codes for neurofibromin (NF1) true or false
Pregunta 19
Pregunta
Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false
Pregunta 20
Pregunta
Tamoxifen is an estrogen receptor antagonist true or false
Pregunta 21
Pregunta
Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false
Pregunta 22
Pregunta
Flutamide and bicalutamide are androgen receptor antagonists true or false