3216761
Descripción
Test por shadow_spiers, actualizado hace más de 1 año
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Creado por shadow_spiers
hace más de 9 años
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Pregunta 1
Pregunta
Which of the following is NOT an advantage of solution dosage form as compared to solid dosage form?
Respuesta
-
Greater Bioavailability
-
Ease of Transportation
-
Ease of Administration
-
Pediatric Use
Pregunta 2
Pregunta
Which of the following is true with regards to the solubility of a weak acid?
Respuesta
-
Solubility increases with decreasing pH
-
Solubility increases with increasing pH
-
Solubility decreases with increasing pH
-
Solubility remains constant with increasing pH
Pregunta 3
Pregunta
A novel compound dissolves in water and the solution becomes cold. Which of the following will further increase the solubility of this compound in water?
Respuesta
-
Decrease in temperature
-
Decreased amount of water
-
Increase in temperature
-
Increased amount of novel compound
Pregunta 4
Pregunta
__________ are dispersions of liquid drugs in liquid vehicles.
Respuesta
-
Suspension
-
Emulsion
-
Colloid
-
Gel
Pregunta 5
Pregunta
Which of the following has the least aqueous solubility
Respuesta
-
CHCl3
-
CCl4
-
CH2Cl2
-
CH3Cl
Pregunta 6
Pregunta
Syrup is a concentrated alcoholic solution with sweetener and medicinal agent ?
Respuesta
-
True
-
False
Pregunta 7
Pregunta
Which of the following is not an example of Cosolvent system?
Respuesta
-
Aromatic Elixir
-
Iodine Tincture
-
Acacia Syrup
-
Paregoric tincture
Pregunta 8
Pregunta
All of the following are advantages of Pharmaceutical solutions EXCEPT
Respuesta
-
Easier to swallow
-
Greater Bioavailability
-
More stable than solid dosage forms
-
Homogenous uniform dosing is possible
Pregunta 9
Pregunta
The two MAJOR factors affecting solubility are?
Respuesta
-
Temperature and agitation
-
pH and particle size
-
Polarity and agitation
-
Temperature and pH
Pregunta 10
Pregunta
To determine the ratio of buffer components to add to a solution to maintain a given pH you should use which equation?
Respuesta
-
pH= pKa + log (salt/acid)
-
pHmax = pKa + Log [(St-Sa)/Sa]
-
B= change in B/ change in pH
-
St= Sa(1+ [Ka/H])
Pregunta 11
Pregunta
All of the following are generally true about Organic Compound Solubility EXCEPT:
Respuesta
-
More carbon atoms decrease the aqueous solubility
-
Halogens decrease solubility
-
Polar groups increase solubility
-
Low melting point indicates low solubility
Pregunta 12
Pregunta
Which of the following would be considered an ethanol/ water cosolvent system.
Respuesta
-
Inverted syrup
-
Magic Mouthwash
-
Paregoric
-
Acacia Syrup
Pregunta 13
Pregunta
Which of the following is an example of a cosolvent?
Respuesta
-
Sodium Acetate
-
Oleic Acid
-
Sodium Benzoate
-
Saccharin Sodium
Pregunta 14
Pregunta
which of the following is NOT a force of attraction that affects dissolution?
Respuesta
-
Ion-dipole
-
Van Der Waals
-
Hydrogen Bonding
-
Ionic Bonding
Pregunta 15
Pregunta
Sedimentation increases with_______?
Respuesta
-
Particle size reduction
-
Increase in viscosity of dispersion medium
-
Increase in density of dispersed phase
-
Increase in density of dispersion medium
Pregunta 16
Pregunta
Which of the following is true when particle aize of an antibiotic powder is reduced from 50 micrometers to 5 micrometers?
Respuesta
-
Higher surface area, Lower surface energy
-
Lower surface area,Higher surface energy
-
Lower surface area, Lower surface energy
-
Higher surface area, higher surface energy
Pregunta 17
Pregunta
Flocculation occurs due to stronger forces of attraction between the particles of a suspension.
Respuesta
-
True
-
False
Pregunta 18
Pregunta
The Sedimentation Volume (F) for an ideal flocculated system is
Respuesta
-
0.5
-
1.0
-
0.7
-
0.3
Pregunta 19
Pregunta
Which of the following is responsible for charge on a neutral particle surface when suspended in water?
Respuesta
-
Adsorption of OH-
-
Adsorption of H2O
-
Particle wetting
-
Particle agglomeration
Pregunta 20
Pregunta
In an electrical double layer which layer is associated with the zeta potential?
Respuesta
-
Bulk layer
-
Diffuse layer
-
Surface layer
-
Stern layer
Pregunta 21
Pregunta
Which of the following situations best represents a deflocculated system?
Respuesta
-
F=0.2
-
F=0.9
-
F=1.0
-
F=1.2
Pregunta 22
Pregunta
Flocculation is observed at extreme (+)ve and (-)ve values of zeta potential.
Respuesta
-
True
-
False
Pregunta 23
Pregunta
The structured vehicle approach is applicable to both flocculated and deflocculated particles.
Respuesta
-
True
-
False
Pregunta 24
Pregunta
Which of the following best represents the flow of flocculated suspension?
Respuesta
-
Newtonian Flow
-
Dilant Flow
-
Plastic Flow
-
Pseudoplastic Flow
Pregunta 25
Pregunta
In which of the following methods oil and emulsifier are mixed first followed by addition of water at once?
Respuesta
-
In-situ soap method
-
English Method
-
Auxiliary Method
-
Continental Method
-
Bottle Method
Pregunta 26
Pregunta
Skin permeation is a must for the component(s) of both medicated and non-medicated topical dosage forms.
Respuesta
- True
- False
Pregunta 27
Pregunta
A major skin permeation pathway for small hydrophilic molecule is?
Respuesta
-
Trans appendageal
-
Hair Follices
-
Transcellular
-
Intercellular
Pregunta 28
Pregunta
Absorption bases are associated with all of the following except?
Respuesta
-
Anhydrous
-
Absorb water
-
Water Washable
-
Hydrous
-
Occlusive
Pregunta 29
Pregunta
What is HFA?
Respuesta
-
Hydroflouroalkane
-
Hydroflorine Association
-
How Far Away
-
Happy Friend Association
Pregunta 30
Pregunta
Droplets decelerate as they leave the spray nozzle of a pressurized spray.
Respuesta
-
True
-
False
Pregunta 31
Pregunta
pDMIs can be sprayed in any orientation
Respuesta
-
True
-
False
Pregunta 32
Pregunta
All medical Aerosol products contain a propellant
Respuesta
-
True
-
False
Pregunta 33
Pregunta
All nasal sprays deliver the same dose independent of the orientation in which they are used
Respuesta
-
True
-
False
Pregunta 34
Pregunta
Which of the following is NOT an advantage of a topical antibiotic sprayed on the skin rather than delivered by a cream.
Respuesta
-
Convenient
-
Minimal contamination of unused product
-
Accurate dose metering
-
No need to touch skin
-
Smaller particle size
Pregunta 35
Pregunta
If inhaled, particles with a diameter of 6 micrometers would be expected to penetrate the respiratory system to the level of the:
Respuesta
-
Bronchioles
-
Alveoli
-
Nasal Cavity
-
Throat (pharynx)
Pregunta 36
Pregunta
For which type(s) of aerosol system(s) will the pressure drop as the product is used?
Respuesta
-
Compressed gas system
-
Three- phase system
-
Two-Phase system
-
B and C only
Pregunta 37
Pregunta
Which part of the valve assembly of an aerosol is responsible for preventing leakage of the formulation from the container?
Respuesta
-
Mounting Cap
-
Actuator
-
Gasket
-
Housing
Pregunta 38
Pregunta
Which of the following is NOT an example of a "surface Spray" aerosol?
Respuesta
-
Dermatological aerosols
-
Paint Sprays
-
Hair Sprays
-
Room deodorizers
Pregunta 39
Pregunta
What is the FDA recommended alcohol content limit in liquid OTC drug product for children 6-12 years?
Respuesta
-
10%
-
1%
-
0.5%
-
5%
Pregunta 40
Pregunta
Which of the following descriptive terms of relative solubility includes 12.5% w/v strength?
Respuesta
-
Very soluble
-
Soluble
-
Slightly soluble
-
Freely Soluble
Pregunta 41
Pregunta
Which of the following groups on organic molecules will NOT increase water solubility?
Respuesta
-
CH2F
-
NH2
-
COOH
-
SO3H
Pregunta 42
Pregunta
Which of the following is the pharmaceutical advantage of elixirs over syrups as liquid dosage forms?
Respuesta
-
Contains less sugar
-
Dissolve ionized and unionized drugs
-
Provide faster drug absorption
-
Are better at masking the taste of drugs
Pregunta 43
Pregunta
Which of the following minimum alcohol percentages is required in medicated syrups to prevent microbial growth?
Respuesta
-
5%
-
0.1%
-
15%
-
1%
Pregunta 44
Pregunta
Water cannot dissolve which of the following organic compounds by intermolecular hydrogen bonds?
Respuesta
-
Esters
-
Alcohol
-
Acids
-
Hydrocarbons
Pregunta 45
Pregunta
Besides accurately and conveniently measuring dosage volume which of the following factors is important when making drug solutions for oral administration?
Respuesta
-
Color
-
Bioavailability
-
Stability
-
Taste
Pregunta 46
Pregunta
Which of the following is an example of an ingredient in an organogel?
Respuesta
-
Sodium alginate
-
Hydrocarbon waxes
-
Polyethylene glycol
-
Carboxylmethylcellulose
Pregunta 47
Pregunta
Which of the following describes the action of a flocculating agent in drug suspensions?
Respuesta
-
Enable loose interparticle attraction
-
Dissolve the suspended particles
-
Prevent interparticle attraction
-
Reduce the particle size
Pregunta 48
Pregunta
Which of the following is a correct statement regarding inhalation drug products (aerosols)?
Respuesta
-
Each successive dose is slightly smaller as the pressure decreases with each actuation.
-
The total quantity of accurate dose from a metered dose inhaler is limited by depletion of the liquid phase of the propellant
-
The total quantity of accurate doses from a metered dose inhaler is limited by depletion of the active drug.
-
chlorofluorocarbon are federally prohibited for use as propellants
Pregunta 49
Pregunta
Which of the following blends of surfactants would favor a stable O/W emulsion?
Respuesta
-
0.5 parts Myrj 45 + 0.5 parts Brij 30
-
0.4 parts Span40 +0.6 parts Tween 20
-
0.6 parts span60 +0.4 parts Tween80
-
0.7 parts span80 + 0.3 parts Tween60
Pregunta 50
Pregunta
Which of the following terms describes a fluid drug preparation that would increasingly flow more freely as it is agitated?
Respuesta
-
Pseudoplastic
-
Plastic
-
Dilant
-
Thixotropic
Pregunta 51
Pregunta
Stoke's Law equation does NOT include which of the following factors?
Respuesta
-
Interparticle Attraction
-
Fluid Density
-
Particle Diameter
-
Gravitational Constant
Pregunta 52
Pregunta
When treating a topical condition, all of the following are suitable criteria for selecting an ointment base for drug delivery EXCEPT:
Respuesta
-
Degree of Occlusion provided
-
Therapeutic systemic blood levels of drug
-
Stability of drug in an ointment base
-
Characteristics of the skin that will be treated.
Pregunta 53
Pregunta
Which of the following is an example of a water soluble base
Respuesta
-
White ointment USP
-
Lanolin USP
-
Polyehtylene Glycol Ointment USP
-
Hydrophillic Ointment USP
Pregunta 54
Pregunta
Which of the following is NOT an appropriate pharmacist counseling point to a patient before applying ophthalmic ointment?
Respuesta
-
Tip of the tube should be placed in gentle contact with the conjunctival sac
-
Patient should wash and dry hands before application
-
Improperly handled ophthalmic products can lead to eye infection
-
After application blurred vision is normal and will likely occur
Pregunta 55
Pregunta
Which of the following is FALSE regarding levigating agents which are used to reduce drug particle size?
Respuesta
-
Glycerin is an appropriate levigating agent for O/W bases
-
The levigating agent must be physically and chemically compatible with the drug and the ointment base
-
The drug for levigation should be soluble in the liquid used as the levegating agent
-
Mineral oil is a good levigating agent for W/O ointment bases
Pregunta 56
Pregunta
Which of the following TDDS products is permitted to be cut into smaller pieces for patient specific therapy?
Respuesta
-
Nitro-Dur
-
Nicoderm
-
Duragesic
-
Fentanyl Patch
-
All of the above
-
None of the above
Pregunta 57
Pregunta
All of the following factors predict favorable transdermal drug absorption for systemic therapy EXCEPT:
Respuesta
-
Full hydration of stratum corneum
-
A high aqueous solubility of the drug
-
Molecular weight of drug of about 100-400
-
A high partition coefficient of the drug
Pregunta 58
Pregunta
Wearing a TDDS for longer than the approved duration can result in unsafe plasma drug concentration
Respuesta
-
True
-
False
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