34387436
Descripción
Test por ACAPUN INSTITUTE, actualizado hace más de 1 año
|
Creado por ACAPUN INSTITUTE
hace alrededor de 3 años
|
|
Pregunta 1
Pregunta
A pharmacologic agonist is a chemical substance that
Respuesta
-
a. Binds to a specific receptor and produces a response
-
b. Elicits a pharmacologic response without binding to a receptor
-
c. Possesses the property of affinity but not of intrinsic activity
-
d. Exhibits no activity except to oppose the effect of an antagonist
Pregunta 2
Pregunta
When comparing drugs with respect to intensity of response, the drug that produces the greatest maximum effect is the one with the highest
Respuesta
-
a. Affinity
-
b. Potency
-
c. Efficacy
-
d. Therapeutic index
Pregunta 3
Pregunta
If drug has a greater efficacy than drug B, then drug A
Respuesta
-
a. Is more toxic than drug B
-
b. Has a greater affinity for the receptor than drug B
-
c. Has a greater margin of safety than drug B
-
d. Is capable of producing a greater maximum effect than drug B
Pregunta 4
Pregunta
A drug with a high LD50 and a low ED50 has a
Respuesta
-
a. High therapeutic index and is, therefore, very dangerous
-
b. High therapeutic index and is, therefore, relatively safe
-
c. Low therapeutic index and is, therefore, very dangerous
-
d. Low therapeutic index and is, therefore, relatively safe
Pregunta 5
Pregunta
The ratio of the median lethal dose (LD50) to the median effective dose (ED50) is the
Respuesta
-
a. Morbidity index
-
b. Mortality index
-
c. Anesthetic ratio
-
d. Therapeutic index
Pregunta 6
Pregunta
The therapeutic index of a drug is the ratio of
Respuesta
-
a. The effective dose to the toxic dose
-
b. Half the toxic dose to half the effective dose
-
c. The maximum tolerated dose to the minimum effective dose
-
d. The lethal dose for 50% of animals to the effective dose for 50% of animals
Pregunta 7
Pregunta
The phenomenon in which two drugs produce opposite effects on a physiologic system but do not act at the same receptor site is
Respuesta
-
a. Potentiation
-
b. Chemical Antagonism
-
c. Competitive antagonism
-
d. Physiologic antagonism
Pregunta 8
Pregunta
Epinephrine antagonizes the effects of histamine by
Respuesta
-
a. Preventing the release of histamine
-
b. Acting on the central nervous system
-
c. Producing physiologic actions opposite to that of histamine
-
d. Competitively blocking histamine at the cellular receptor site
Pregunta 9
Pregunta
Interaction between nitroglycerin and epinephrine is what type of antagonism?
Respuesta
-
a. Allosteric
-
b. Physiologic
-
c. Biochemical
-
d. Competitive
-
e. Pharmacologic
Pregunta 10
Pregunta
When the combined action of two drugs is greater than the sum of their individual actions, this is
Respuesta
-
a. Induction
-
b. Synergism
-
c. Idiosyncrasy
-
d. Hypersensitivity
-
e. Cumulative action
Pregunta 11
Pregunta
Which of the following responses is least predictable in occurrence?
Respuesta
-
a. Toxicity
-
b. Side-effects
-
c. Idiosyncrasy
-
d. Tachyphylaxis
-
e. Therapeutic effects
Pregunta 12
Pregunta
Idiosyncrasies to drugs are related to
Respuesta
-
a. Species
-
b. Genetic factors
-
c. Age of the patient
-
d. All of the above
Pregunta 13
Pregunta
Two drugs, A and B, have the same mechanism of action. Drug A in a dose of 5 mg. produces the same magnitude of response as drug B in a dose of 500 mg. Which of the following statements is correct?
Respuesta
-
a. Drug A is less toxic
-
b. Drug A is more efficacious
-
c. Drug A is 100 times as potent
-
d. Drug A has a shorter duration of action
-
e. Drug A is a better drug to use when a maximal response is desired
Pregunta 14
Pregunta
According to the theory that agonists and antagonists occupy the same receptor site, an effective antagonist should exhibit
Respuesta
-
a. High intrinsic activity and high affinity
-
b. Low intrinsic activity and low affinity
-
c. High intrinsic activity and low affinity
-
d. No intrinsic activity and high affinity
Pregunta 15
Pregunta
All of the following statements are true regarding the occupation theory of drug-receptor interaction EXCEPT:
Respuesta
-
a. The affinity of a drug is dependent on its intrinsic activity
-
b. The maximum effect of a drug occurs when all receptors are occupied
-
c. An antagonist has affinity for the receptor but not intrinsic activity
-
d. The magnitude of the effect of a drug is proportional to the number of receptors occupied
-
e. It follows the law of mass action
Pregunta 16
Pregunta
The occupational theory of drug-receptor interaction states that
a. The magnitude of the drug response is proportional to the number of receptors occupied
b. A partial agonist has intrinsic activity but no affinity for the receptor site
c. An antagonist drug has affinity but no intrinsic activity
d. The rate at which the drug-receptor complex associates and dissociates determines drug efficacy
e. The degree of drug action is dependent on the law of mass action
Respuesta
-
a) (a), (b) and (c)
-
b) (a), (c) and (e)
-
c) (b), (c) and (d)
-
d) (b) and (e)
-
e) (c), (d) and (e)
¿Quieres crear tus propios Tests gratis con GoConqr? Más información.