34387436
Descripción
Test por ACAPUN INSTITUTE, actualizado hace más de 1 año
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Creado por ACAPUN INSTITUTE
hace más de 2 años
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Pregunta 1
Pregunta
A pharmacologic agonist is a chemical substance that
Respuesta
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a. Binds to a specific receptor and produces a response
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b. Elicits a pharmacologic response without binding to a receptor
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c. Possesses the property of affinity but not of intrinsic activity
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d. Exhibits no activity except to oppose the effect of an antagonist
Pregunta 2
Pregunta
When comparing drugs with respect to intensity of response, the drug that produces the greatest maximum effect is the one with the highest
Respuesta
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a. Affinity
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b. Potency
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c. Efficacy
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d. Therapeutic index
Pregunta 3
Pregunta
If drug has a greater efficacy than drug B, then drug A
Respuesta
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a. Is more toxic than drug B
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b. Has a greater affinity for the receptor than drug B
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c. Has a greater margin of safety than drug B
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d. Is capable of producing a greater maximum effect than drug B
Pregunta 4
Pregunta
A drug with a high LD50 and a low ED50 has a
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a. High therapeutic index and is, therefore, very dangerous
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b. High therapeutic index and is, therefore, relatively safe
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c. Low therapeutic index and is, therefore, very dangerous
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d. Low therapeutic index and is, therefore, relatively safe
Pregunta 5
Pregunta
The ratio of the median lethal dose (LD50) to the median effective dose (ED50) is the
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a. Morbidity index
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b. Mortality index
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c. Anesthetic ratio
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d. Therapeutic index
Pregunta 6
Pregunta
The therapeutic index of a drug is the ratio of
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a. The effective dose to the toxic dose
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b. Half the toxic dose to half the effective dose
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c. The maximum tolerated dose to the minimum effective dose
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d. The lethal dose for 50% of animals to the effective dose for 50% of animals
Pregunta 7
Pregunta
The phenomenon in which two drugs produce opposite effects on a physiologic system but do not act at the same receptor site is
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a. Potentiation
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b. Chemical Antagonism
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c. Competitive antagonism
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d. Physiologic antagonism
Pregunta 8
Pregunta
Epinephrine antagonizes the effects of histamine by
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a. Preventing the release of histamine
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b. Acting on the central nervous system
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c. Producing physiologic actions opposite to that of histamine
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d. Competitively blocking histamine at the cellular receptor site
Pregunta 9
Pregunta
Interaction between nitroglycerin and epinephrine is what type of antagonism?
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a. Allosteric
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b. Physiologic
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c. Biochemical
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d. Competitive
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e. Pharmacologic
Pregunta 10
Pregunta
When the combined action of two drugs is greater than the sum of their individual actions, this is
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a. Induction
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b. Synergism
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c. Idiosyncrasy
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d. Hypersensitivity
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e. Cumulative action
Pregunta 11
Pregunta
Which of the following responses is least predictable in occurrence?
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a. Toxicity
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b. Side-effects
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c. Idiosyncrasy
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d. Tachyphylaxis
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e. Therapeutic effects
Pregunta 12
Pregunta
Idiosyncrasies to drugs are related to
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a. Species
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b. Genetic factors
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c. Age of the patient
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d. All of the above
Pregunta 13
Pregunta
Two drugs, A and B, have the same mechanism of action. Drug A in a dose of 5 mg. produces the same magnitude of response as drug B in a dose of 500 mg. Which of the following statements is correct?
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a. Drug A is less toxic
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b. Drug A is more efficacious
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c. Drug A is 100 times as potent
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d. Drug A has a shorter duration of action
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e. Drug A is a better drug to use when a maximal response is desired
Pregunta 14
Pregunta
According to the theory that agonists and antagonists occupy the same receptor site, an effective antagonist should exhibit
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a. High intrinsic activity and high affinity
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b. Low intrinsic activity and low affinity
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c. High intrinsic activity and low affinity
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d. No intrinsic activity and high affinity
Pregunta 15
Pregunta
All of the following statements are true regarding the occupation theory of drug-receptor interaction EXCEPT:
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a. The affinity of a drug is dependent on its intrinsic activity
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b. The maximum effect of a drug occurs when all receptors are occupied
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c. An antagonist has affinity for the receptor but not intrinsic activity
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d. The magnitude of the effect of a drug is proportional to the number of receptors occupied
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e. It follows the law of mass action
Pregunta 16
Pregunta
The occupational theory of drug-receptor interaction states that
a. The magnitude of the drug response is proportional to the number of receptors occupied
b. A partial agonist has intrinsic activity but no affinity for the receptor site
c. An antagonist drug has affinity but no intrinsic activity
d. The rate at which the drug-receptor complex associates and dissociates determines drug efficacy
e. The degree of drug action is dependent on the law of mass action
Respuesta
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a) (a), (b) and (c)
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b) (a), (c) and (e)
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c) (b), (c) and (d)
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d) (b) and (e)
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e) (c), (d) and (e)
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