Classical Pathway

Which one of these cleaves C4 into C4a and C4b?

Which antibody/antibodies can activate the classical pathway?

[blank_start]1[blank_end] pentameric [blank_start]IgM[blank_end] or [blank_start]2[blank_end] [blank_start]IgG[blank_end] [blank_start]in close proximity to each other[blank_end] are required to activate the classical pathway.

C3 convertase cleaves [blank_start]C3[blank_end] into [blank_start]C3a[blank_end] and [blank_start]C3b[blank_end]

[blank_start]C3b[blank_end] [blank_start]covalently attaches to[blank_end] [blank_start]C3 convertase[blank_end]

C5 convertase of the classical pathway is also known as [blank_start]C4b2a3b[blank_end]

C5b initiates formation of [blank_start]MAC complex[blank_end]

MAC complex stands for [blank_start]Membrane[blank_end] [blank_start]Attack[blank_end] Complex

MAC complex is initiated by C5a

MAC complex is initiated by C5b

The classical pathway pf the complement system is independent of antibody.

The C3 convertase of the classical pathway is also known as [blank_start]C4b2a[blank_end].

The C3 convertase of the classical pathway is C3bBb.

What does C3a do in the classical pathway of the complement system?

What does C3b do in the classical pathway of the complement system?

C2 binds to membrane bound [blank_start]C4b[blank_end], and is cleaved by [blank_start]C1s[blank_end] into [blank_start]C2a[blank_end] and [blank_start]C2b[blank_end]. [blank_start]C2a[blank_end] remains bound to C4b.