Pregunta 1
Pregunta
Select all that apply. Which of the following are β-lactamase penicillins?
Respuesta
-
Ampicillin
-
Ticarcillin
-
Methicillin
-
Piperacillin
-
Nafcillin
-
Amoxicillin
Pregunta 2
Pregunta
What does PBP1A bind to?
Respuesta
-
Transpeptidase
-
Carboxypeptidase
-
Endopeptidase
Pregunta 3
Pregunta
Penicillin G is stable in gastric acid.
Pregunta 4
Pregunta
Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
Respuesta
-
Penicillin G
-
Nafcillin
-
Ampicillin
-
Piperacillin
-
Amoxicillin
-
All of the above
Pregunta 5
Pregunta
One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
Pregunta 6
Pregunta
Select all that apply. The mechanism of action for penicillins are:
Respuesta
-
concentration dependent bactericidal action
-
time dependent bactericidal action
-
works best against rapidly dividing bacteria
-
works best against slowly dividing bacteria
-
inhibits transpeptidase activity of PBP3
Pregunta 7
Pregunta
Which of the following cause neutropenia?
Pregunta 8
Pregunta
Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
Respuesta
-
Binds to ribosome 30s to prohibit protein synthesis
-
Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
-
Inhibits the cross-linkages between the peptidoglycan polymer strands
-
Disrupts the integrity of the cell membrane by displacing calcium and magnesium
Pregunta 9
Pregunta
Which bacteria are susceptible to enzyme inactivation by beta lactamases?
Respuesta
-
Cephalosporins
-
Macrolides
-
Metronidazole
-
Tetracyclines
Pregunta 10
Pregunta
Penicillins are narrow spectrum drugs
Pregunta 11
Pregunta
Select all of the bactericidal antibiotics.
Respuesta
-
Macrolides
-
Penicillin
-
Tetracycline
-
Cephalexin
-
Aminoglycosides
-
Clindamycin
Pregunta 12
Pregunta
Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
Pregunta 13
Pregunta
Which of the following is incorrect regarding Penicillin G/Penicillin V
Respuesta
-
Used for mixed aerobic-anaerobic infections
-
Used against gram positive and gram negative bacteria
-
One of these two can be used for treatment of Rheumatic fever
-
These are all correct
Pregunta 14
Pregunta
Which of the following is not an antistaphylococcal penicillin?
Pregunta 15
Pregunta
Penicillins work by inhibiting with enzyme?
Respuesta
-
Integrase
-
Peptidyl transferase
-
Transpeptidase
-
Transcriptase
Pregunta 16
Pregunta
Penicillin V is administered by IV only
Pregunta 17
Pregunta
Which of the following is NOT a possible adverse effect from penicillins?
Respuesta
-
Allergy
-
Phlebitis
-
Fungal overgrowth
-
Hemolytic anemia
Pregunta 18
Pregunta
Which of the following is true regarding aminopenicillins?
Respuesta
-
Resistant to beta lactamases
-
Narrow spectrum
-
Ampicillin has less side effects than amoxicillin
-
Effective against gonorrhea and meningitis
Pregunta 19
Pregunta
Select the following that are ineffective against beta lactamases:
Respuesta
-
Penicillin V
-
Penicillin G
-
Dicloxacillin
-
Amoxicillin
Pregunta 20
Pregunta
Which of the following best represents first generation cephalosporins?
Respuesta
-
Includes Cefotaxime and Ceftriaxone
-
Used for UTI (urinary tract infections) and soft tissue abscesses
-
Effective against Klebsiella and H influenza
-
Used for treatment of community-acquired pneumonia
Pregunta 21
Pregunta
Which of the following best describes the second generation of cephalosporins?
Respuesta
-
Drug of choice for surgical prophylaxis
-
Used to treat meningitis
-
Includes the drug Cefuroxime
-
Includes the drug Cefepime
Pregunta 22
Pregunta
Protein synthesis inhibitors are considered narrow spectrum antibiotics
Pregunta 23
Pregunta
Tetracyclines are broad spectrum antibiotics
Pregunta 24
Pregunta
Which of the following best matches the mechanism of tetracyclines?
Respuesta
-
Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
-
Becomes mechanically reduced to toxic metabolite, interacting with DNA
-
Binds to 50s subunit, preventing binding of tRNA to mRNA
-
Binds to 30s subunit, preventing binding of tRNA to mRNA
Pregunta 25
Pregunta
Which of the following are targeted by tetracyclines?
Pregunta 26
Pregunta
Which of the following is INCORRECT regarding macrolides?
Respuesta
-
Broad spectrum
-
Used as an alternative for patients allergic to penicillins
-
Can be bacteriostatic or bacteriocidal, depending on dose (concentration)
-
Kills gram positive and gram negative bacteria
Pregunta 27
Pregunta
Which of the following is incorrect regarding Chloramphenicol?
Pregunta 28
Pregunta
Chloramphenicol can cause gray baby syndrome.
Pregunta 29
Pregunta
Which of the following is NOT a use for Clindamycin?
Respuesta
-
Pseudomembranous colitis
-
Anthrax
-
Toxic shock syndrome
-
Odontogenic infection
Pregunta 30
Pregunta
Which of the following is NOT a concern for use of Clindamycin?
Pregunta 31
Pregunta
What is the clinical use of sulfonamides?
Pregunta 32
Pregunta
Sulfonamide is a structural analog of DFHR
Pregunta 33
Pregunta
Sulfonamides can cause which of the following adverse effects?
Respuesta
-
Photosensitivity
-
Pseudomembranous colitis
-
Neutropenia
-
Seizures
Pregunta 34
Pregunta
Clotrimazole can be used for UTI (urinary tract infections)
Pregunta 35
Pregunta
How do fluoroquinolones kill bacteria?
Respuesta
-
They bind to topoisomerase-DNA complexes and form an inactive complex
-
They bind to bacterial ribosomes 30s
-
They inhibit transpeptidases
-
They compromise the integrity of the bacterial cell membrane
Pregunta 36
Pregunta
Which of the following can cause Red Man Syndrome?
Respuesta
-
Penicillin
-
Erythromycin
-
Vancomycin
-
Sulfamethoxazole
Pregunta 37
Pregunta
Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
Respuesta
-
nephrotoxicity
-
vestibular toxicity
-
tooth discoloration
-
cochlear toxicity
Pregunta 38
Pregunta
Which of the following cannot be used to treatment of MRSA?
Respuesta
-
Linezolid
-
Vancomycin
-
Streptogramins
-
Clindamycin
Pregunta 39
Pregunta
MRSA is resistant to ALL penicillins and cephalosporins
Pregunta 40
Pregunta
Which of the following does NOT increase risk of nephrotoxicity?
Respuesta
-
Aminoglycosides
-
Amphoterecin B
-
Cisplatin
-
Macrolides
Pregunta 41
Pregunta
Nystatin is not related to Amphoterecin B and can therefore be used systemically.
Pregunta 42
Pregunta
What type of fungal infection does nystatin treat?
Respuesta
-
Cryptococcal meningitis
-
Candida infections
-
Histoplasmosis
-
Asperillosis
Pregunta 43
Pregunta
Choose all of the trizoles.
Respuesta
-
Ketoconazole
-
Itraconazole
-
Fluconazole
-
Voriconazole
-
Miconazole
-
Clotrimazole.
Pregunta 44
Pregunta
What is the correct mechanism of azoles?
Respuesta
-
Disrupts microtubule function and inhibits dermatophyte growth
-
Binds to membrane Ergosterol
-
Inhibits viral DNA polymerase
-
Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane
Pregunta 45
Pregunta
Which of the following is NOT an adverse effect of Azoles
Pregunta 46
Pregunta
Which of the following antifungals are used to disrupt microtubule (spindle) function?
Respuesta
-
Terbinafine
-
Griseofulvin
-
Echinocandins
-
Ketoconazole
Pregunta 47
Pregunta
Which of the following antifungals is used for onychomychosis and tinea?
Respuesta
-
Griseofulvin
-
Terbinafine
-
Echinocandins
-
Ketoconazole
Pregunta 48
Pregunta
Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
Respuesta
-
Acyclovir
-
Ganciclovir
-
Raltegravir
-
Retrovir
Pregunta 49
Pregunta
Ganciclovir causes myelosuppression
Pregunta 50
Pregunta
What is the therapeutic use for Penicillin?
Respuesta
-
Drug of choice for streptococci, pneumococcal, and staphylococcal infections
-
Treat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
-
Treatment of a broad range of gram positive and gram negative organisms
-
Treatment of patients who are unable to tolerate penicillins
Pregunta 51
Pregunta
What is the pharmacological class for Penicillin G?
Respuesta
-
Aminoglycoside, protein synthesis inhibitor
-
Fluroquinolone, bacterial DNA synthesis inhibitor
-
Natural penicillin, cell wall inhibitor, beta lactam
-
Mycolic acid inhibitor
Pregunta 52
Pregunta
What is the pharmacological class of Cefotaxime?
Respuesta
-
Beta lactam antibiotic, cell wall inhibitor
-
Tetracycline, protein synthesis inhibitor
-
Macrolide, protein synthesis inhibitor
Pregunta 53
Pregunta
Mechanism of action for Cefotaxime?
Respuesta
-
Inhibits cell wall synthesis
-
Inhibits bacterial protein synthesis and prevents replication
-
Inhibits synthesis of mycolic acid
Pregunta 54
Pregunta
Tetracycline mechanism of action?
Respuesta
-
Inhibits bacterial protein synthesis and prevents cell replication
-
Inhibits bacterial gyrase
-
Inhibits cell wall synthesis
Pregunta 55
Pregunta
What is the pharmacologic class for erythromycin?
Respuesta
-
Macrolide, protein synthesis inhibitor
-
Aminoglycoside, protein synthesis inhibitor
-
Beta lactam antibiotic
Pregunta 56
Pregunta
What is the mechanism of action for erythromycin?
Respuesta
-
Inhibits protein synthesis
-
Inhibits cell wall synthesis
-
Binds to peptidoglycan
-
Inhibits bacterial protein synthesis and prevents cell replication
Pregunta 57
Pregunta
What is the pharmacologic class for gentamicin?
Respuesta
-
Fluoroquinolone
-
Sulfonamide, folic acid inhibitor
-
Aminoglycoside, protein synthesis inhibitor
-
Mycolic acid inhibitor
Pregunta 58
Pregunta
What is the mechanism of action for Gentamicin?
Respuesta
-
Inhibits bacterial metabolism of folic acid
-
Inhibits protein synthesis, disrupting cell membrane and killing bacteria
-
Inhibits synthesis of mycolic acids
-
Inhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error
Pregunta 59
Pregunta
Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
Pregunta 60
Pregunta
What is the pharmacological class and mechanism of action for ciprofloxacin?
Respuesta
-
Fluoroquinolone, inhibits bacterial DNA gyrase
-
Mycolic acid inhibitor, inhibits mycolic acid
-
Aminoglycoside, inhibits protein synthesis
-
Sulfonamide, inhibits bacteiran metabolism of folic acid
Pregunta 61
Pregunta
Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
Pregunta 62
Pregunta
What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
Respuesta
-
fluroquinolone, inhibits bacterial DNA gyrase
-
sulfonamide, inhibits bacterial metabolism of folic acid
-
aminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria
Pregunta 63
Pregunta
Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
Respuesta
-
Mebendazole
-
Amphotericin B
-
Fluconazole
-
Cloroquine
Pregunta 64
Pregunta
What is the mechanism of action for Mebendazole?
Respuesta
-
Concentrates in food vacuoles of plasmodium residing in red blood cells
-
Inhibits microtubule formation and glucose uptake
-
Binds to ergosterol in fungal cell membranes and causes them to leak
-
Interferes with ergosterol synthesis
Pregunta 65
Pregunta
What is the therapeutic class for Amphotericin B?
Respuesta
-
Antihelminth
-
Antifungal
-
Antifungal (systemic)
-
Antimalarial
Pregunta 66
Pregunta
Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
Respuesta
-
Fluconazole
-
Cloroquine
-
Mebendazole
-
Amphotericin B
Pregunta 67
Pregunta
Select all the following drugs that are polyenes.
Respuesta
-
Amphotericin B
-
Echinocandin
-
Griseofulvin
-
Nystatin
Pregunta 68
Pregunta
What is the therapeutic class for the drug Fluconazole?
Respuesta
-
Antihelminth
-
Antifungal
-
Antibacterial
-
Antiviral