Cholinergic Drugs

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Pregunta 1

Pregunta
Which drugs are used for glaucoma [blank_start]Pilocarpine[blank_end] [blank_start]Carbachol[blank_end]
Respuesta
  • Pilocarpine
  • Suprarenin
  • Carbachol
  • Benzatropine

Pregunta 2

Pregunta
What are the symptoms of nerve gas poisoning. Organize symptoms into groups:
Respuesta
  • Nicotinic signs: Neuromuscular (twitching, fasciculation, paralysis)
  • Central signs: Headache, drowsiness, disorientation, coma or generalized convulsion
  • Muscarinic signs: Miosis, nausea, salvitation, vomiting, diarrhea, sweating, bradycardia, bronchial constriction.
  • Treatment: Atropine (muscarinic receptor antagonist), diazepam (for convulsion) and pralidoxime or obidoxime (reactivators)

Pregunta 3

Pregunta
What are indications for Benzatropine
Respuesta
  • Parkinson’s disease
  • blurred vision
  • fast heartbeats
  • vomiting or constipation
  • little or no urination

Pregunta 4

Pregunta
Side effects of atropine
Respuesta
  • hallucinations
  • dry mouth
  • constipation
  • dryness of skin
  • tachycardia
  • urine retention
  • Blocking of acetylcholine

Pregunta 5

Pregunta
Rivastigmine - Method of Action and indications of
Respuesta
  • Reversible inhibitor of acetylcholinesterase (Indirect acting cholinergic agonist)
  • Alzheimer’s disease, dementia
  • quite well absorbed by oral route and crossing well the blood brain barrier
  • Organophosperus poisoning
  • Parkinson´s Disease
  • symptomatical dehydration

Pregunta 6

Pregunta
Tropicamide Indications
Respuesta
  • Dilation of the pupil (connected with examination before & after surgery)
  • Mydriasis
  • Countering of Opiod abuse opthalamic symptoms

Pregunta 7

Pregunta
3 Alzheimer Drugs
Respuesta
  • Donepezil
  • Rivastigmine
  • Gelantamine

Pregunta 8

Pregunta
Muscarine Poisoning:
Respuesta
  • Increased Salivation, sweating, lacrimation
  • Bradycardia, Block, Hypertension
  • Generally subsides within 2 Hours
  • Dyspnoe, blurrred vision, abdominal pain with nausea and diarrhea
  • The specific antigen is Atropine

Pregunta 9

Pregunta
Neostigmine
Respuesta
  • Reversible Inhibitor of acetylcholinesterase
  • Prioritizes Digestive tract and Bladder over CVS & CNS
  • Treatment in myasthenia gravis, posoperative atony (intestine/bladder)
  • neostigmine indirectly stimulates both nicotinic and muscarinic receptors
  • reversible cholinesterase inhibitor

Pregunta 10

Pregunta
Clinical Indications of parasympathic agonists
Respuesta
  • Bradycardia, Hypotension, Coronary insufficiency
  • Cardiac Block
  • Hyperthyroidism
  • Asthma
  • peptic Ulcers

Pregunta 11

Pregunta
Method of Action of Buscopan
Respuesta
  • peripheral effects similar to those of atropine
  • sedative and tranquillizing action and has an amnestic effect
  • treat abdominal cramping and irritable bowel syndrome => antispasmodics acting on the smooth musculature
  • used as an antiemetic agent in the prevention of motion sickness

Pregunta 12

Pregunta
Indication for Atropine
Respuesta
  • antidote in muscarinic poisoning
  • biliary and renal colic pain used as antispasmodic for painful smooth muscle spasms
  • cardiology: treatment of bradykardia and block.
  • anesthesiology : prevention of respiratory tract secretion ● bronchospasm ● laryngospasm ● reflexes
  • Atrial Fibrilation

Pregunta 13

Pregunta
How does Dopamine act?
Respuesta
  • D1 – stimulated at low concentration. Induces renal, mesenteryc and coronary vasodilation. Increase renal blood flow and GFR, Na excretion.
  • B1 – Stimulated at higher concentration. Postitive inotropic effect
  • A1 stimulated at high concentrations.Induces vasoconstriction

Pregunta 14

Pregunta
Side effects of epinephrine
Respuesta
  • fear anxiety, restlessness, tremor
  • hypertension & Cardiac arrythmias, can cause anginal pain
  • cerebral haemorrhage
  • Worse in hyperthyroid and hypersensitive patients.

Pregunta 15

Pregunta
Isoprenaline indications
Respuesta
  • bradycardia
  • atrioventricular block

Pregunta 16

Pregunta
Isoprenaline has only cardiovascular indications
Respuesta
  • True
  • False

Pregunta 17

Pregunta
Drugs used to prevent premature labour and receptors
Respuesta
  • Salbutamol (short-acting β2 adrenergic receptor agonist)
  • Terbutaline (beta‑adrenergic agonist)
  • Ritodrine (short-acting β2 adrenoreceptor agonist)

Pregunta 18

Pregunta
short-acting β2 adrenergic receptor agonist / β2 Stimulants are used in prevention of premature labour / preterm delivery, they act on the utereine smooth muscle cell β2 receptors causing relaxation
Respuesta
  • True
  • False

Pregunta 19

Pregunta
short-acting β2 & 3 adrenergic receptor antagonist are used in prevention of premature labour / preterm delivery, they act on the utereine smooth muscle cell β3 receptors causing relaxation
Respuesta
  • True
  • False

Pregunta 20

Pregunta
Asthma treatment
Respuesta
  • Epinephrine for asthma attacks: Stimulates α1, α2, β1, β2, β3 adrenergic receptors
  • Ipratropium / Atrovent; Muscarinic receptor antagonist reduce the effects of acetylcholine
  • Salbutamol Inhalator relaxing SMC in the airways by acting on β2 receptors (short acting)

Pregunta 21

Pregunta
Treatment of bradycardia
Respuesta
  • done by using beta1 and beta2 agonists.
  • Isoprenaline
  • orciprenaline
  • atropine with clinical monitoring

Pregunta 22

Pregunta
Side Efffeects of Norepinephrine
Respuesta
  • sudden numbness, weakness, or cold feeling anywhere in your body
  • hypertension
  • reduced blood flow in organs, kidney, liver, brain
  • necrosis at site of administration
  • problems with vision, speech, or balance; or severe headache, blurred vision, pounding in your neck or ears

Pregunta 23

Pregunta
Nasal drops are Alpha 2 agonists with local effects
Respuesta
  • True
  • False

Pregunta 24

Pregunta
Nasal Drops are Alpha 1 effects with peripheral effects but with local administration they give more localized effects
Respuesta
  • True
  • False

Pregunta 25

Pregunta
Nasal Drops (α1 agonists)
Respuesta
  • Phenylepinephrine
  • Naphazoline
  • Tymazoline
  • Ksylometazoline

Pregunta 26

Pregunta
Indications of Epinephrine
Respuesta
  • Anaphylactic Shock
  • Cardiac arrest
  • Asthma attack
  • Glaucoma
  • used with local anaesthesia to reduce their effusion from injection site

Pregunta 27

Pregunta
Dobutamine
Respuesta
  • primarily used in congestive heart failure and shock with low cardiac output
  • β1 agonist
  • ide effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection
  • positive ionotropic action

Pregunta 28

Pregunta
Prevention of Asthma Attacks
Respuesta
  • Salmeterol,
  • formoterol
  • bambuterol
  • Ipratropium
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