Clinical Medicine: Pulmonary Vascular Disease

Descripción

Pulmonary Vascular Disease ppt
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Resumen del Recurso

Pregunta 1

Pregunta
Mortality rates in the first 3 months following a PE dx are:
Respuesta
  • 1.5%
  • 5%
  • 15%
  • 30%
  • 50%

Pregunta 2

Pregunta
Emboli begin as thrombi which may consist of:
Respuesta
  • fat
  • air
  • tumor
  • Only A & B
  • All of the above

Pregunta 3

Pregunta
Venous thromboembolism may originate from:
Respuesta
  • DVTs
  • catheters
  • infections
  • A & C only
  • All of the above

Pregunta 4

Pregunta
Which of the following are physiologic anticoagulants that oppose thrombosis?
Respuesta
  • AT-III
  • Fibrin
  • Protein C
  • A & C only
  • All of the above

Pregunta 5

Pregunta
Which of the following are the most common sources for clinically important pulmonary emboli? (select all that apply)
Respuesta
  • Subclavian veins
  • Right Atrium/Ventricle
  • Femoral vein
  • Iliac vein
  • Pelvic vein

Pregunta 6

Pregunta
Which of the following compose Virchow's Triad:
Respuesta
  • Factors in the vessel wall (e.g. tissue damage)
  • Abnormal blood flow (e.g. venous stasis)
  • Abnormal/Hypercoagulable states
  • Abnormal/Hypocoagulable states
  • Abnormal branching of vessels

Pregunta 7

Pregunta
Which of the following may cause venous stasis?
Respuesta
  • Surgery
  • Congestive Heart Failure
  • Pregnancy
  • Only A & B
  • All of the above

Pregunta 8

Pregunta
Which of the following may cause hypercoagubility? (select all that apply)
Respuesta
  • Oral contraceptives
  • Hormone Replacement Therapy
  • Pregnancy
  • Malignancy
  • Excesses of Proteins C or S

Pregunta 9

Pregunta
Over 95% of pulmonary emboli are thromboemboli.
Respuesta
  • True
  • False

Pregunta 10

Pregunta
Which of the following are NOT true regarding the natural history of a venous thomboembolism?
Respuesta
  • Non-extended distal DVTs rarely cause PE
  • 80% of symptomatic DVTs have extended into the distal veins
  • 60% of pts w/ symptomatic DVTs w/ will have a PE
  • 70% of pts with symptomatic PE will have asymptomatic DVTs
  • DVTs most often start in the calf (distal) veins

Pregunta 11

Pregunta
Of the following sxs, which are all associated w/ PE, which is the least common? (choose one)
Respuesta
  • Dyspnea
  • Cough
  • Leg Pain/Swelling
  • Pleuritic chest pain
  • Hemoptysis
  • Wheezing
  • Orthopnea

Pregunta 12

Pregunta
Which of the following is the most common sign associated with PE? (found in approximately 54% of PE presentations)
Respuesta
  • Tachypnea
  • Calf swelling/tenderness
  • Tachycardia
  • Decreased breath sounds
  • Crackles

Pregunta 13

Pregunta
Which of the following is NOT part of the PERC clinical decision tool (i.e. HADCLOTS) used for diagnosing PE?
Respuesta
  • Surgery/trauma w/in past 28 days
  • Coughing blood
  • Lower extremity swelling unilaterally
  • O2 Saturation <95%
  • All of the above are associated with PERC

Pregunta 14

Pregunta
Which of the following pairs would have the HIGHEST Wells score?
Respuesta
  • 1) PE most likely dx (on ddx), 2) Hemoptysis
  • 1) Clinical signs and sxs of DVT, 2) Immobilization for > 3 consecutive days or surgery in previous 4 weeks
  • 1) Previous Dx of PE or DVT, 2) Cancer (tx w/in past 6 mo)
  • 1) Tachycardia (>100bpm), 2) Immobilization for > 3 consecutive days or surgery in previous 4 weeks
  • 1) PE most likely dx (on ddx), 2) Cancer (tx w/in past 6 mo)

Pregunta 15

Pregunta
An EKG & Chest X-ray can be helpful tools in diagnosing a PE.
Respuesta
  • True
  • False

Pregunta 16

Pregunta
Which of the following may be found on a chest x-ray of a pt w/ PE? (note: these are neither sensitive nor specific findings)
Respuesta
  • Decreased vascular markings in an area of lung (i.e. Westermark’s sign)
  • Wedge-shaped infiltrate extending to the pleural surface (i.e. Hampton’s hump)
  • Normal (no abnormal findings)
  • Only A & B
  • All of the above

Pregunta 17

Pregunta
Which of the following may be found on an EKG of a pt w/ PE? (note: these are neither sensitive nor specific findings)
Respuesta
  • Ventricular arrhythmias
  • Left bundle branch block
  • S1 Q3 T3 pattern
  • Only A & C
  • All of the above

Pregunta 18

Pregunta
Which of the following clinical signs of PE is shown on this x-ray?
Respuesta
  • Westermark's sign
  • Hampton's hump

Pregunta 19

Pregunta
Which of the following clinical signs of PE is shown on this x-ray?
Respuesta
  • Westermark's sign
  • Hampton's hump

Pregunta 20

Pregunta
Which of the following is NOT true regarding use of CT angiography in dx of PE? (select any that apply)
Respuesta
  • Bolus radiocontrast injection given intravenously.
  • High speed, multi-slice CT scanner takes thin section images.
  • Excellent definition of main and lobar.
  • May detect central and peripheral emboli.
  • May provide bonus information about the lungs and mediastinal structures.

Pregunta 21

Pregunta
CT scanning has excellent (~90%) positive predictive values.
Respuesta
  • True
  • False

Pregunta 22

Pregunta
Pulmonary angiography is considered the "gold standard" for dx of PE.
Respuesta
  • True
  • False

Pregunta 23

Pregunta
Which of the following statements is/are NOT accurate regarding pulmonary angiography.
Respuesta
  • Considered the "gold standard" in dx PE
  • Allows measurement of pulmonary artery pressures
  • It is both invasive and expensive
  • Frequently used to confirm dx of PE
  • Requires administration of intravenous radiocontrast

Pregunta 24

Pregunta
Which of the following is/are NOT true in regards to V/Q scanning in dx of PE: (select any that apply)
Respuesta
  • perfusion scanning uses venous injection with radiolabeled- macroaggregated albumin (technetium 99)
  • ventilation scanning requires Iinhalation of a gas mixture containing a radiotracer (xenon 133)
  • it is sensitive for decreased flow to areas of the pulmonary vascular bed, but not specific
  • a normal perfusion scan excludes the diagnosis of PE.
  • in PE cases, areas of vascular obstruction should show decreased ventilation but preserved perfusion

Pregunta 25

Pregunta
A "high probability" V/Q scan result, coupled with high clinical suspicion, gives a > 95% likelihood of PE.
Respuesta
  • True
  • False

Pregunta 26

Pregunta
A negative (i.e. normal) D-Dimer result may be used to rule-out DVT and PE, regardless of clinical presentation and probability scores.
Respuesta
  • True
  • False

Pregunta 27

Pregunta
Which of the following labs is LEAST helpful in the dx of PE?
Respuesta
  • CBC
  • ABG
  • BNP
  • Troponin
  • INR, PTT

Pregunta 28

Pregunta
Which of the following labs/results are NOT properly matched, in regards to dx PE.
Respuesta
  • ABG: hypoxemia, widened alveolar-arterial gradient, and respiratory alkalosis
  • BNP: may be elevated due to right heart strain
  • Troponin: may be decreased in 30-50% of cases
  • PTT: needed for baseline when considering tx options

Pregunta 29

Pregunta
A D-Dimer test could be positive in which of the following cases?
Respuesta
  • Pregnancy
  • Infection
  • Post-Op
  • Trauma
  • All of the above

Pregunta 30

Pregunta
According to the diagnostic algorithm for pulmonary embolism, if the pt's Wells score exceeds 4, what is the next step?
Respuesta
  • D-Dimer
  • CT angiography
  • Pulmonary Angiography
  • Ultrasound (serial venous doppler)
  • V/Q scan

Pregunta 31

Pregunta
According to the diagnostic algorithm for pulmonary embolism, if the pt's Wells score is below 4, what is the next step?
Respuesta
  • No treatment (PE dx excluded)
  • D-Dimer to confirm
  • Chest X-ray to confirm
  • Serial Venous Doppler (US) to rule-out DVT
  • Labs to confirm (BNP, LFT, CBC, etc.)

Pregunta 32

Pregunta
Small emboli discovered in the course of dx are relatively benign and do not require tx.
Respuesta
  • True
  • False

Pregunta 33

Pregunta
Which three signs/sxs are most indicative of an acute PE?
Respuesta
  • Hemodynamic instability (hypotension)
  • AMS
  • Shock
  • Hemoptysis
  • Tachycardia

Pregunta 34

Pregunta
Prompt use of heparin in pt's w/ a DVT helps to lyse the clot and reduce mortality.
Respuesta
  • True
  • False

Pregunta 35

Pregunta
Mortality of PE after the initiation of heparin decreases to <5%
Respuesta
  • True
  • False

Pregunta 36

Pregunta
Which of the following anticoagulants is the treatment of choice in pt's w/ a bleeding risk?
Respuesta
  • Low molecular weight heparin
  • Unfractionated heparin
  • High molecular weight heparin
  • Fractionated heparin
  • None of the above (Anticoagulants are contraindicated in pt's w/ bleeding risk)

Pregunta 37

Pregunta
Which of the following statement is NOT accurate?
Respuesta
  • Unfractionated Heparin requires frequent lab monitoring
  • Unfractioned Heparin requires continuous infusion due to a short half-life
  • Unfractionated Heparin is reversible
  • LMW Heparin is administered via intramuscular injections
  • LMW Heparin does not require frequent monitoring and may be managed at home

Pregunta 38

Pregunta
Which of the following is NOT true regarding Rivaroxaban & Dabigatran?
Respuesta
  • they are oral medications approved by the FDA for the tx of PE
  • their risk of causing bleeding events is comparable or less than that of coumadin
  • they are both reversible
  • neither require close monitoring
  • they are both thrombin inhibitors

Pregunta 39

Pregunta
Thrombolytics are only indicated in hemodynamically stable patients.
Respuesta
  • True
  • False

Pregunta 40

Pregunta
Thromolytic tx may cause an intracranial hemorrhage.
Respuesta
  • True
  • False

Pregunta 41

Pregunta
Thrombolyics are typically administered by a vascular surgeon and/or radiologist.
Respuesta
  • True
  • False

Pregunta 42

Pregunta
Which of the following might necessitate the use of an IVC ?
Respuesta
  • Pt. w/ bleeding problems
  • Pt. allergic/intolerant to anticoagulants
  • Pt. in need of acute stabilization
  • A & B only
  • All of the above

Pregunta 43

Pregunta
Which of the following are predictors of poor outcomes for pt's w/ hx of PE? (choose all that apply)
Respuesta
  • Hypotension
  • Hypoxemia
  • Coexisting DVT
  • Decreased lactate
  • Decreased WBC

Pregunta 44

Pregunta
A resting pulmonary artery pressure of ________ is considered pulmonary hypertension.
Respuesta
  • more than 25mmHg
  • more than 35mmHg
  • more than 45mmHg
  • more than 55mmHg

Pregunta 45

Pregunta
Pulmonary hypertension may be:
Respuesta
  • familial
  • arise from areas affected by PE
  • related to drug toxicity
  • secondary to pulmonary venous congestion (e.g. left ventricular failure)
  • All of the above

Pregunta 46

Pregunta
Pulm. HTN is due to hypoxia and hypoxemia and may be seen in diseases such as COPD.
Respuesta
  • True
  • False

Pregunta 47

Pregunta
An increase in blood flow, such as one experiences while exercising, will cause a proportional increase across the pulmonary vascular bed.
Respuesta
  • True
  • False

Pregunta 48

Pregunta
Which of the following may cause pulm HTN (via chronic hypoxemia): (select all that apply)
Respuesta
  • Chronic high altitude
  • COPD
  • Pulmonary fibrosis
  • Obstructive sleep apnea
  • Chronic Asthma

Pregunta 49

Pregunta
Which of the following may also cause pulm HTN: (select all that apply)
Respuesta
  • Parasitic infections
  • Recurrent/unresolved PE
  • Cocaine use
  • HIV
  • Syphilis
  • Liver disease
  • Allergies

Pregunta 50

Pregunta
Idiopathic pulm HTN is most common in women, ages 20-45 years old, and is due to medial hypertrophy and intimal proliferation and fibrosis.
Respuesta
  • True
  • False

Pregunta 51

Pregunta
Common symptoms of Pulm HTN may include: (choose all that apply)
Respuesta
  • Dyspnea
  • Dysphagia
  • Peripheral edema
  • Syncope
  • Chest pain

Pregunta 52

Pregunta
Possible signs of pulm HTN may include:
Respuesta
  • Carvahlo's sign (tricuspid murmur, regurg. w/ inspir.)
  • Prominent pulmonic component of second heart sound
  • Right ventricular (S3) gallop
  • JVD
  • Transient periods of tachycardia
  • Distended spleen
  • Left ventricular hypertrophy
  • Corrigan's pulse (alternates weak and bounding)

Pregunta 53

Pregunta
All of the following are possible lab/diagnostic findings in Pulm HTN, EXCEPT:
Respuesta
  • Polycythemia
  • Decreased PaO2
  • Stenosis of main pulmonary (CXR)
  • Cardiomegaly (CXR)
  • Elevated Pulm Pressures (ECG & Echo)

Pregunta 54

Pregunta
Which of the following are potential treatments for Pulm HTN: (select all that apply)
Respuesta
  • Long-term anticoagulation (even when not due to chronic PE)
  • Vasodilators (especially for Primary Pulm HTN)
  • Lung Transplantation
  • Supplemental O2
  • Cardiopulmonary bypass

Pregunta 55

Pregunta
Of the vasodilators used to tx pulm HTN, which is the most controversial?
Respuesta
  • Calcium channel blockers
  • Prostacyclin
  • Endothelin receptor blockers
  • All vasodilators are controversial in tx of Pulm HTN

Pregunta 56

Pregunta
Which of the following statements is NOT accurate regarding Cor Pulmonale?
Respuesta
  • Right ventricular failure due to pulmonary disease
  • Usually accompanied by hypercapnia
  • Most commonly caused by pulm HTN, COPD, or pulm fibrosis
  • Chronic and progressive

Pregunta 57

Pregunta
Which are NOT common sxs associated with Cor Pulmonale:
Respuesta
  • Cough
  • Swelling of face/neck
  • Cyanosis
  • JVD
  • Dysphagia
  • Gallop S3 heart rhythm

Pregunta 58

Pregunta
Common lab findings in Cor Pulmonale include:
Respuesta
  • Westermark sign on CXR
  • RAD, RVH on EKG
  • Polycythemia on CBC
  • B & C only
  • All of the above

Pregunta 59

Pregunta
All of the following are used to tx Cor Pulmonale EXCEPT:
Respuesta
  • ACE Inhibitors/Angiotensin Receptor Blockers
  • Dopamine/dobutamine
  • Anticoagulants
  • Beta-2 Agonists

Pregunta 60

Pregunta
This is a rare autoimmune disease that affects the kidneys and lungs, causing necrosis of alveoli and loss of gas exchange.
Respuesta
  • Goodpasture's Syndrome
  • Wegener's Granulomatosis

Pregunta 61

Pregunta
While Goodpasture's may affect persons of all ages, it is found to be more common in younger males and older females.
Respuesta
  • True
  • False

Pregunta 62

Pregunta
Signs/Sxs that might differentiate Goodpasture's from diseases such as PE and Pulmonary HTN, include: (select all that apply)
Respuesta
  • Hematuria
  • Pallor
  • Weight Loss
  • Myalgia
  • Proteinuria

Pregunta 63

Pregunta
Which of the following diagnostics are indicated in a work-up for Goodpasture's syndrome? (Select all that apply)
Respuesta
  • Anti-glomerular basement membrane test
  • ABG
  • BUN
  • CXR
  • LFT
  • Lung & Kidney Biopsy
  • MRI

Pregunta 64

Pregunta
Goodpasture's Syndrome is treated with:
Respuesta
  • Plasma exchange to remove antibodies
  • Immunosuppressants
  • Steroids
  • A & B only
  • All of the above

Pregunta 65

Pregunta
This rare disease causes "geograpahic" necrosis and granulomatous inflammation of the airways.
Respuesta
  • Goodpasture's
  • Wegener's

Pregunta 66

Pregunta
Wegener's granulomatous is believed to be caused by cellular immune processes and may present w/ respiratory and renal involvement.
Respuesta
  • True
  • False

Pregunta 67

Pregunta
Which of the following statements concerning Wegener's granulomatous is FALSE ?
Respuesta
  • It is a rare disease
  • Equally prevalent in men and women
  • Typically occurs in the 4th-5th decade of life
  • Is fatal within one year if not treated
  • All of the above statements are TRUE

Pregunta 68

Pregunta
This rare disease can cause recurrent sinusitis, chronic ear infections, and a variety of flu-like sxs.
Respuesta
  • Wegener's
  • Goodpasture's

Pregunta 69

Pregunta
The work-up for this disease includes a blood test for anti-neutrophil cytoplasmic antibodies.
Respuesta
  • Wegener's
  • Goodpasture's

Pregunta 70

Pregunta
While many survivors may be dependent on dialysis, the 5-year survival rate for Wegener's granulomatous is about 70%
Respuesta
  • True
  • False
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