450600
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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Pregunta 1
Pregunta
What is the main role of a molecular chaperone?
Respuesta
-
Assist in the folding of other proteins
-
Assist in the unfolding of other proteins
-
Assist in the assembly of other proteins
-
Assist in the disassembly of other proteins
Pregunta 2
Pregunta
Chaperone proteins are permanent parts of the proteins they fold
Respuesta
- True
- False
Pregunta 3
Pregunta
Why are chaperone proteins necessary?
Respuesta
-
Some proteins have complex folding pathways,
-
Some proteins are inherently soluble
-
Useful for multimeric assembly
-
So many proteins folding and interacting mean some need help
Pregunta 4
Pregunta
Name the role of the domain highlighted in bacterial trigger factor
Respuesta
-
PPIase domain
-
Interacts with polypeptide as it comes off the ribosome
-
Binds to L23 of the ribosome
Pregunta 5
Pregunta
The highlighted domain of Bacterial trigger factor binds to L23 of the ribosome
Respuesta
- True
- False
Pregunta 6
Pregunta
The bacterial ribosome and bacterial trigger factor form a complex, so the protein is folded as it comes off the ribosome
Respuesta
- True
- False
Pregunta 7
Pregunta
The N-domain of the bacterial trigger factor bind to what subunit of what size ribosome?
Respuesta
-
L23
-
L24
-
L25
-
50s
-
40s
-
30s
Pregunta 8
Pregunta
After the protein interacts with the T.F, it may interact with what proteins?
Respuesta
-
DNAK
-
DNAJ
-
DNAL
-
Gro-EL
-
Gro-ER
Pregunta 9
Pregunta
What percent of proteins can fold unaided after interacting with DNAK/J?
Respuesta
-
70%
-
65%
-
75%
Pregunta 10
Pregunta
10-15% of proteins need to use the lidded protein chaperone syastem
Respuesta
- True
- False
Pregunta 11
Pregunta
15-18% of proteins need further _ interactions?
Respuesta
-
DNAK
-
DNAJ
-
Gro-El
Pregunta 12
Pregunta
Yeast has no trigger factor
Respuesta
- True
- False
Pregunta 13
Pregunta
In yeast, what protein folding complex interacts with the proteins first?
Respuesta
-
Nascent Polypeptide Associated Complex (NAC)
-
The Ribosome Associated Complex (RAC)
-
CCT
Pregunta 14
Pregunta
The RAC complex is made of which proteins?
Respuesta
-
Zuptin
-
Hsp40
-
SSZ
-
Hsp70
Pregunta 15
Pregunta
SSB is separated from the RAC but also chaperones protein folding
Respuesta
- True
- False
Pregunta 16
Pregunta
The NAC is made of A and B homologues
Respuesta
- True
- False
Pregunta 17
Pregunta
What is the role of the NAC?
Respuesta
-
Bind to nascent proteins and prevent aggregation
-
Binds to nascent proteins and degrades them based on protein concentrations in the cell
-
Binds to nascent proteins and folds them
Pregunta 18
Pregunta
Human cellss don't possess an NAC
Respuesta
- True
- False
Pregunta 19
Pregunta
Humans have an hRAC rather than an RAC
Respuesta
- True
- False
Pregunta 20
Pregunta
The human version of the RAC contains which two proteins?
Respuesta
-
MPP11
-
SSz
-
Hsp70L1
-
SSb
Pregunta 21
Pregunta
Name the lidded protein chaperone found in yeast and humans
Respuesta
-
Gro-El
-
CCT
-
SSb
-
Hsp70L1
Pregunta 22
Pregunta
Name the circled sets of cytoplasmic folding proteins
Respuesta
-
Hsp40/70- humans
-
Hsp40/70- yeast
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SSa/YDJ1- yeast
-
Ssa/Ydj1- humans
-
Prefoldin
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