471718
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace casi 11 años
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Pregunta 1
Pregunta
Define leukamia
Respuesta
-
Neoplastic proliferation of haemopeoietic or lymphoid cells
-
Neoplastic proliferation of lymphoid cells
-
Neoplastic proliferation of bone marrow
Pregunta 2
Pregunta
In acute leukaemia, abnormality occurs in mature cells
Respuesta
- True
- False
Pregunta 3
Pregunta
Acute leukaemia is described as a block in differentiation
Respuesta
- True
- False
Pregunta 4
Pregunta
Acute leukaemia is caused by acute proliferation of...
Respuesta
-
Myeloblasts
-
Lymphoblasts
-
Both (rare)
-
Both (most common)
Pregunta 5
Pregunta
What are the symptoms of chronic leukaemia?
Respuesta
-
No block in differentiation
-
Block in differentiation
-
Low proliferation
-
High proliferation
Pregunta 6
Pregunta
Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?
Respuesta
-
Blasts
-
Reticulocytes
-
Lympocytes
Pregunta 7
Pregunta
In A.L, there are often reticulocytes in the peripheral blood
Respuesta
- True
- False
Pregunta 8
Pregunta
Leukaemia is caused by clonal proliferation from a single cell
Respuesta
- True
- False
Pregunta 9
Pregunta
How can you (sometimes) differentiate between a myeloblast and a lymphoblast?
Respuesta
-
Myeloblasts have auer rods
-
Lymphoblasts have auer rods
-
Myeloblasts have a large, pale nucleus
-
Lymphoblasts have a large, pale nucleus
Pregunta 10
Pregunta
MUD stands for
Respuesta
-
Matched Unrelated Donor
-
Myeloblast Unknown Death
-
Myeloblasts Under Duress
Pregunta 11
Pregunta
Remission - no disease in the blood
Respuesta
- True
- False
Pregunta 12
Pregunta
Why use the Minimal Residual Disease (MUD)?
Respuesta
-
Assess chances at relapse/need for further treatment
-
Assess effectiveness of drug
-
Prevent remission
Pregunta 13
Pregunta
BMT - Bone Marrow Transplant
Respuesta
- True
- False
Pregunta 14
Pregunta
B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults
Respuesta
- True
- False
Pregunta 15
Pregunta
Which of the following is has the poorer prognosis
Respuesta
-
Acute T-Cell Precursor Lymphoblastic
-
Acute B-Cell Precursor Lymphoblastic
Pregunta 16
Pregunta
What is found in cytogenetic testing of ALL?
Respuesta
-
Hyperploidy
-
Aneuploidy
-
Nullosomy
Pregunta 17
Pregunta
Which of the following are found in ALL cytochemistry?
Respuesta
-
MPX/SB are neg
-
MPX/SB are pos
-
PAS block pos
-
PAS block neg
Pregunta 18
Pregunta
Which of the following are found in Immunophenotyping for ALL?
Respuesta
-
CD19
-
CD7
-
CD10
Pregunta 19
Pregunta
What is true of AML?
Respuesta
-
Inc WBC
-
Dec RBC
-
Dec Plateles
-
Inc RBC
-
Inc Platelets
Pregunta 20
Pregunta
AML means there is no normal cells
Respuesta
- True
- False
Pregunta 21
Pregunta
What markers are used in Flow Cytometry to identify AML?
Respuesta
-
CD13
-
CD33
-
CD12
-
CD4
Pregunta 22
Pregunta
AML is more common in adult women
Respuesta
- True
- False
Pregunta 23
Pregunta
When is AML called 'De Novo'
Respuesta
-
When it occurs for the first time
-
If it occurs secondary to other malignancies
-
If it never relapses
Pregunta 24
Pregunta
Which of the following is common in AML (as opposed to ALL)
Respuesta
-
CNS leukaemia
-
Lymph, spleen and gum problems
-
Lymphodenopathy
Pregunta 25
Pregunta
Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising
1 = Low Platelets 2= Low Hb 3 = Low WBC
Respuesta
-
A2, B3, C1
-
A1, B2, C3
-
A3 B2 C1
Pregunta 26
Pregunta
CML- accumulation of mature myeloid cells
Respuesta
- True
- False
Pregunta 27
Pregunta
Genetic anomalies in CML occur low down where they effect cells
Respuesta
- True
- False
Pregunta 28
Pregunta
What happens in 95% of cases to cause AML?
Respuesta
-
Chromosome 22 shortens
-
Linking BCR & ABL genes together
-
Chromosome 22 inverts
-
Chromosome 22 lengthens
Pregunta 29
Pregunta
In indentifying CML, immunophenotyping is useless
Respuesta
- True
- False
Pregunta 30
Pregunta
CML is more common in adult men
Respuesta
- True
- False
Pregunta 31
Pregunta
What is the WBC in CML?
Respuesta
-
>50 x 10^9/l
-
<30 x 10^9/l
-
>75 x 10^9/l
Pregunta 32
Pregunta
What will be found in a CML bone marrow sample?
Respuesta
-
Bone marrow is hypercellular
-
Bone marrow is hypocellular
-
Myeloid cells are present at all developmental stages
-
Inc Neutraphil Alkaline Phosphatase
-
Red Neutraphil Alkaline Phosphatase
Pregunta 33
Pregunta
Glivec stops CML cells dividing, but is expensive
Respuesta
- True
- False
Pregunta 34
Pregunta
CLL- Neoplastic proliferation of mature looking lymphocytes
Respuesta
- True
- False
Pregunta 35
Pregunta
What ususally happens in CML?
Respuesta
-
Lymphoids form masses in the bone marrow, spleen and lymph nodes
-
Lymphoids lyse and release contents as they are made poorly
-
Lymphs begin attacking body cells
Pregunta 36
Pregunta
In CLL, the lymph population can be over 300x the normal
Respuesta
- True
- False
Pregunta 37
Pregunta
What are smear cells?
Respuesta
-
Cells that rupture during a smear
-
Cells so malleable they look like smudges
-
Cells so deformed they form masses, which look like smears
Pregunta 38
Pregunta
In CLL, the bone marrow is <25% lymphocytes
Respuesta
- True
- False
Pregunta 39
Pregunta
What does immunophenotyping in CLL tell us?
Respuesta
-
Clonality
-
Which lymph cells they are
-
The markers
Pregunta 40
Pregunta
CLL is more common in old men
Respuesta
- True
- False
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