Pregunta 1
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The Extrinsic Pathway operates on the initiating cell
Pregunta 2
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What is the role of the Extrinsic Pathway?
Pregunta 3
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The Intrinsic Pathway works on...
Respuesta
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The endothelium
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The vW factor
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The platelet surface
Pregunta 4
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The Intrinsic pathway is designed to generate thrombin bursts
Pregunta 5
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Name the three steps of Coagulation
Respuesta
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Initiation
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Amplification
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Propagation
Pregunta 6
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What begins the Initiation phase?
Respuesta
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Vascular injury initiates trigger factor
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Vascular injury exposes collagen for platelets to bind
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Vascular injury causes blood cells to lyse
Pregunta 7
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Trigger factor activates VII, which activates smal amounts of
Pregunta 8
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X & XI bind to platelets and produce small amounts of Thrombulin
Pregunta 9
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Thrombin initiates Amplification
Pregunta 10
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The platelets act as a surface for the assembly of what factor complexes?
Respuesta
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IX & VIII
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Prethrombinase (X & V)
Pregunta 11
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What happens in Propogation
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Activated platelets/complexes generate Thrombin Burst
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Activated platelets/complexes generate Thrombulin Burst
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Activated platelets/complexes generate Thromblin Burst
Pregunta 12
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What two things are required for Fibrin Clot formation?
Respuesta
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Fibrinogen --> Fibrin
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F IIa
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F III
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F V
Pregunta 13
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Thrombin production is the crucial step in haemostasis
Pregunta 14
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The first step in Coagulation Disorder diagnosis is a family & drug history
Pregunta 15
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Name the two main clinical presentation of coagulation disorders
Respuesta
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Bleeding in deep tissues
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Bleeding in joints
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Flushed skin
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Easy cutting of skin
Pregunta 16
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Prethrombin Time is anassessment of the _ Pathway
Pregunta 17
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Prethrombin time is expressed as an international, normalised ratio
Pregunta 18
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Activated Partial Thromboplastin Time is an indicator of...
Respuesta
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Intrinsic pathway
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Extrinsic pathway
Pregunta 19
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Which of the following are not Coagulation Disorder investigations?
Respuesta
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Fibrinogen Assay
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FXIII Screen
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Thrombin Clotting Time
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Fibin Clotting Time
Pregunta 20
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How do you evaluate increased prethrombin time?
Pregunta 21
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How do you evaluate Activated Partial Thromboplastin Time (APPT)?
Pregunta 22
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Lack o Factor X causes no symptoms
Pregunta 23
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Factor I assay is used if bot PT and APTT is elevated
Pregunta 24
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If both PT and APTT is normal, what is tested for?
Pregunta 25
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Aquired Coagulation Deficiencies are caused by a lack of what?
Pregunta 26
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What can cause Aquired Vit K deficiency?
Pregunta 27
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Vit-K deficiency can be drug induced i.e. in the case of liver disease
Pregunta 28
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Haemophilia A is caused by what?
Respuesta
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Factor VIII deficiency
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Factor VI deficiency
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Factor V deficiency
Pregunta 29
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Haemophilia A is sex linked
Pregunta 30
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Haemophilia B is a Factor IX deficiency
Pregunta 31
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The mutations for Haemophilia A & B are found on which chromosome?
Pregunta 32
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How do you identify Haemophilia B?
Respuesta
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Inc PT
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Inc APTT
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Factor IX assay
Pregunta 33
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Von Willebrands disease is caused by a lack of factor
Pregunta 34
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vW disease is detected by
Pregunta 35
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Since many things can effect the levels of vWF, testing is difficult
Pregunta 36
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vW disease can be qualitative or quantitative