5232031
Descripción
Test por sbpharmacy, actualizado hace más de 1 año
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Creado por sbpharmacy
hace más de 8 años
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Pregunta 1
Pregunta
What is the scientific name for cancer?
[blank_start]Oncology[blank_end]
Respuesta
-
Oncology
Pregunta 2
Pregunta
What is the word used for a cancerous growth?
[blank_start]Malignant[blank_end]
Respuesta
-
Malignant
Pregunta 3
Pregunta
Carcinomas derive from [blank_start]epithelial cells[blank_end]
Respuesta
-
epithelial cells
Pregunta 4
Pregunta
What type of tumour derives from connective tissue?
[blank_start]Sarcomas[blank_end]
Respuesta
-
Sarcomas
Pregunta 5
Pregunta
What type of tumour derives from thin layers of tissue surrounding internal organs?
[blank_start]Mesotheliomas[blank_end]
Respuesta
-
Mesotheliomas
Pregunta 6
Pregunta
What type of tumour derives from glial cells in the brain?
[blank_start]Gliomas[blank_end]
Respuesta
-
Gliomas
Pregunta 7
Pregunta
[blank_start]Germinomas[blank_end] derive from germ cells (which are non-[blank_start]differentiated[blank_end] cells)
Respuesta
-
Germinomas
-
differentiated
Pregunta 8
Pregunta
What does leukemia derive from?
[blank_start]Bone marrow[blank_end]
Respuesta
-
Bone marrow
Pregunta 9
Pregunta
The proportion of tumour cells dividing and cycling is known as the [blank_start]growth[blank_end] [blank_start]fraction[blank_end]
Respuesta
-
growth
-
fraction
Pregunta 10
Pregunta
Name three folic acid antagonists.
1 - [blank_start]methotrexate[blank_end]
2 - [blank_start]pemetrexed[blank_end]
3 - [blank_start]raltitrexed[blank_end]
Respuesta
-
methotrexate
-
pemetrexed
-
raltitrexed
Pregunta 11
Pregunta
Name four pyrimidine analogues.
1 - [blank_start]fluorouracil[blank_end]
2 - [blank_start]cytarabine[blank_end]
3 - [blank_start]capecitabine[blank_end]
4 - [blank_start]gemcitabine[blank_end]
Respuesta
-
fluorouracil
-
cytarabine
-
capecitabine
-
gemcitabine
Pregunta 12
Pregunta
Name five purine analogues.
1 - [blank_start]mercaptopurine[blank_end]
2 - [blank_start]thioguanine[blank_end]
3 - [blank_start]cladribine[blank_end]
4 - [blank_start]clorabine[blank_end]
5 - [blank_start]fludarabine[blank_end]
Respuesta
-
mercaptopurine
-
thioguanine
-
cladribine
-
clorabine
-
fludarabine
Pregunta 13
Pregunta
Methotrexate works by attacking/inhibiting [blank_start]dihydrofolate[blank_end] reductase. This prevents [blank_start]dihydrofolate[blank_end] being converted into [blank_start]tetrahydrofolate[blank_end].
Respuesta
-
dihydrofolate
-
dihydrofolate
-
tetrahydrofolate
Pregunta 14
Pregunta
Fluorouracil mimics which nitrogenous base?
Respuesta
-
cytosine
-
guanine
-
thiamine
-
adenine
Pregunta 15
Pregunta
Name two main nitrogen mustard based alkylating agents.
1 - [blank_start]chlorambucil[blank_end]
2 - [blank_start]cyclophosphamide[blank_end]
Respuesta
-
chlorambucil
-
cyclophosphamide
Pregunta 16
Pregunta
Alkylating agents, such as [blank_start]cyclophosphamide[blank_end], work by [blank_start]crosslinking[blank_end] between [blank_start]guanine[blank_end] nitrogenous bases. This produces a [blank_start]stable[blank_end] structure which is hard to break meaning DNA is not longer able to [blank_start]replicate[blank_end].
Respuesta
-
cyclophosphamide
-
crosslinking
-
guanine
-
stable
-
replicate
Pregunta 17
Pregunta
Cisplatin and carboplatin are examples of which anticancer type drugs?
[blank_start]platinating agents[blank_end]
Respuesta
-
platinating agents
Pregunta 18
Pregunta
Name two platinating agents.
1 - [blank_start]cisplatin[blank_end]
2 - [blank_start]carboplatin[blank_end]
Respuesta
-
cisplatin
-
carboplatin
Pregunta 19
Pregunta
Which main element do platinating agents contain?
[blank_start]platinum[blank_end]
Respuesta
-
platinum
Pregunta 20
Pregunta
In [blank_start]aqueous[blank_end] conditions, the [blank_start]chlorine[blank_end] group of platinating agents is replaced with [blank_start]water[blank_end]. The nitrogen on the [blank_start]guanine[blank_end] base can displace water and binds tightly to the drug.
Respuesta
-
aqueous
-
chlorine
-
water
-
guanine
Pregunta 21
Pregunta
The bond formed by platinating agents and DNA bases is stronger than the covalent bonds formed between alkylating agents and DNA bases.
Respuesta
- True
- False
Pregunta 22
Pregunta
Antitumor antibiotics and derived from [blank_start]Streptomyces[blank_end] species.
Respuesta
-
Streptomyces
Pregunta 23
Pregunta
Name six main groups/drugs of antibiotics used in cancer chemotherapy (in alphabetical order).
1 - [blank_start]anthracyclines[blank_end]
2 - [blank_start]bleomycin[blank_end]
3 - [blank_start]dactinomycin[blank_end]
4 - [blank_start]hydroxycarbamide[blank_end]
5 - [blank_start]mitomycin C[blank_end]
6 - [blank_start]procarbazine[blank_end]
Respuesta
-
anthracyclines
-
bleomycin
-
dactinomycin
-
hydroxycarbamide
-
mitomycin C
-
procarbazine
Pregunta 24
Pregunta
The main anticancer anthracycline antibiotic is [blank_start]doxorubicin[blank_end].
Respuesta
-
doxorubicin
Pregunta 25
Pregunta
Anthracyclines are used mainly in lung, breast cancer, and leukaemia.
Respuesta
- True
- False
Pregunta 26
Pregunta
Which enzyme does doxorubicin inhibit?
[blank_start]topoisomerase II[blank_end]
Respuesta
-
topoisomerase II
Pregunta 27
Pregunta
What is the main adverse effect of anthracyclines?
[blank_start]Cardiotoxicity[blank_end]
Respuesta
-
Cardiotoxicity
Pregunta 28
Pregunta
Dactinomycin is used mainly for breast, stomach, lung, pancreas, bladder, and anal cancers.
Respuesta
- True
- False
Pregunta 29
Pregunta
Dactinomycin works mainly by [blank_start]intercalating[blank_end] with DNA at the [blank_start]transcription initiation[blank_end] complex, which prevents [blank_start]RNA polymerase[blank_end] action.
Respuesta
-
intercalating
-
transcription initiation
-
RNA polymerase
Pregunta 30
Pregunta
Bleomycin is used mainly for treatment of Hodgkin's lymphoma, and non-Hodgkin's lymphoma.
Respuesta
- True
- False
Pregunta 31
Pregunta
Bleomycin works by [blank_start]chelating[blank_end] with [blank_start]metal[blank_end] ions (mainly [blank_start]iron[blank_end]), which produces [blank_start]free-radicals[blank_end] that [blank_start]cleave[blank_end] DNA. Oxygen is required for this to occur.
Respuesta
-
chelating
-
metal
-
iron
-
free-radicals
-
cleave
Pregunta 32
Pregunta
Dactinomycin causes pulmonary fibrosis and dermatological toxicity.
Respuesta
- True
- False
Pregunta 33
Pregunta
Mitomycin C is a [blank_start]pro-drug[blank_end]. It is enzymatically activated to produce an [blank_start]alkylating[blank_end] metabolite.
Respuesta
-
pro-drug
-
alkylating
Pregunta 34
Pregunta
Procarbazine is used mainly in the treatment of Hodgkin's lymphoma.
Respuesta
- True
- False
Pregunta 35
Pregunta
Procarbazine is a [blank_start]pro-drug[blank_end] which breaks down to [blank_start]azo-carbazine[blank_end] in the body. This reaction produces [blank_start]hydrogen peroxide[blank_end] which causes damage to [blank_start]DNA[blank_end]. It interferes with DNA and RNA [blank_start]synthesis[blank_end].
Respuesta
-
pro-drug
-
azo-carbazine
-
hydrogen peroxide
-
DNA
-
synthesis
Pregunta 36
Pregunta
Hydroxycarbamide interacts with many drugs because it inhibits monoamine oxidase.
Respuesta
- True
- False
Pregunta 37
Pregunta
[blank_start]Hydroxycarbamide[blank_end] is used for the treatment of chronic myelogenous leukaemia.
Respuesta
-
Hydroxycarbamide
Pregunta 38
Pregunta
Hydroxycarbamide works by inhibiting [blank_start]ribonucleotide reductase[blank_end]. This enzyme is responsible for catalysing DNA from RNA strands.
Respuesta
-
ribonucleotide reductase
Pregunta 39
Pregunta
What is the main side effect of hydroxycarbamide?
[blank_start]Myelosuppression[blank_end]
Respuesta
-
Myelosuppression
Pregunta 40
Pregunta
ABVD is the name of one the chemotherapy treatments used to treat [blank_start]Hodgkin's lymphoma[blank_end]. It is made up of the drugs
A = [blank_start]Adriamycin[blank_end]
B = [blank_start]Bleomycin[blank_end]
C = [blank_start]Vinblastine[blank_end]
D = [blank_start]Dacarbazine[blank_end]
Respuesta
-
Hodgkin's lymphoma
-
testicular cancer
-
non-Hodgkin's lymphoma
-
breast cancer
-
bladder cancer
-
brain tumours
-
Adriamycin
-
Amsacrine
-
Alemtuzumab
-
Aromasin
-
Aclarubicin
-
Bleomycin
-
Busulfan
-
Buserelin
-
Bevacizumab
-
Vinblastine
-
Vectibix
-
Viadur
-
Vincristine
-
Vindesine
-
Vinorelbine
-
Dacarbazine
-
Doxorubicin
-
Daunorubicin
-
Dactinomycin
Pregunta 41
Pregunta
Name four plant derived cancer therapy agents.
1. C[blank_start]amptothecins[blank_end]
2. E[blank_start]toposide[blank_end]
3. T[blank_start]axanes[blank_end]
4. V[blank_start]inca[blank_end] a[blank_start]lkaloids[blank_end]
Respuesta
-
amptothecins
-
toposide
-
axanes
-
inca
-
lkaloids
Pregunta 42
Pregunta
Vinca alkaloids are derived from Madagascar Periwinkle.
Respuesta
- True
- False
Pregunta 43
Pregunta
Vinca alkaloids work by binding to [blank_start]tubulin[blank_end]. This prevents [blank_start]spindle[blank_end] formation in mitosis. The disruption of [blank_start]microtubules[blank_end] stops mitosis in [blank_start]metaphase[blank_end]. Vinca alkaloids affect all [blank_start]rapidly[blank_end] dividing cell types.
Respuesta
-
tubulin
-
spindle
-
microtubules
-
metaphase
-
rapidly
Pregunta 44
Pregunta
Vincristine is used in the treatment of non-Hodgkin's lymphoma and Hodgkin's lymphoma.
Respuesta
- True
- False
Pregunta 45
Pregunta
The brand name for vincristine is [blank_start]Oncovin[blank_end]
Respuesta
-
Oncovin
Pregunta 46
Pregunta
Name two taxane drugs.
1. [blank_start]Paclitaxel[blank_end]
2. [blank_start]Docetaxel[blank_end]
Respuesta
-
Paclitaxel
-
Docetaxel
Pregunta 47
Pregunta
Taxanes work by stabilising [blank_start]microtubules[blank_end] preventing [blank_start]mitosis[blank_end].
Respuesta
-
microtubules
-
mitosis
Pregunta 48
Pregunta
Camptothecins inhibits topoisomerase I
Respuesta
- True
- False
Pregunta 49
Pregunta
Etoposide inhibits topoisomerase I
Respuesta
- True
- False
Pregunta 50
Pregunta
Name two camptothecins.
1. t[blank_start]opotecan[blank_end]
2. i[blank_start]rinotecan[blank_end]
Respuesta
-
opotecan
-
rinotecan
Pregunta 51
Pregunta
Name six anthracyclines (other than doxorubicin)
1 - a[blank_start]driamycin[blank_end]
2 - a[blank_start]clarubicin[blank_end]
3 - d[blank_start]aunorubicin[blank_end]
4 - e[blank_start]pirubicin[blank_end]
5 - i[blank_start]darubicin[blank_end]
6 - m[blank_start]itozantrone[blank_end]
Respuesta
-
driamycin
-
clarubicin
-
aunorubicin
-
pirubicin
-
darubicin
-
itozantrone
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