Virology (week 7)

Descripción

DVM2 Virology Test sobre Virology (week 7), creado por Kathryn Borg el 07/05/2016.
Kathryn Borg
Test por Kathryn Borg, actualizado hace más de 1 año
Kathryn Borg
Creado por Kathryn Borg hace más de 8 años
13
2

Resumen del Recurso

Pregunta 1

Pregunta
What genera belong to the family Coronaviridae?
Respuesta
  • Torovirus
  • Coronavirus
  • Orbivirus
  • Rotavirus

Pregunta 2

Pregunta
What is interesting about the coronavirus genera?
Respuesta
  • They cause a wide variety of clinical disease
  • The virus is highly stable in the environment, surviving years without a host
  • The virus is resistant to pH
  • The virus causes latent infection

Pregunta 3

Pregunta
What clinical symptoms do coronaviruses cause?
Respuesta
  • Enteric
  • Neurological
  • Respiratory
  • Immunological

Pregunta 4

Pregunta
What is the basic structure of coronaviridae?
Respuesta
  • Non-enveloped, spherical, single stranded positive sense RNA
  • Enveloped, spherical, single stranded positive sense RNA
  • Enveloped, spherical, single stranded DNA
  • Enveloped, spherical, double stranded positive sense RNA
  • Non-enveloped, spherical, double stranded positive sense RNA

Pregunta 5

Pregunta
What areas of the body does the coronaviridae have a "tropism" for?
Respuesta
  • Respiratory and/or gastrointestinal epithelium
  • Respiratory and/or myocaridal epithelium
  • Bone marrow and lymph nodes
  • Respiratory and/or circulatory system endothelium

Pregunta 6

Pregunta
Why is Bovine Coronavirus Diarrhoea important?
Respuesta
  • Second most common cause of diarrhoea in calves
  • Most common cause of diarrhoea in calves
  • Most common cause of abortions in cattle
  • Leads to infertility in cattle

Pregunta 7

Pregunta
When are calves most likely to be affected by Bovine coronavirus diarrhoea?
Respuesta
  • Less than 2 weeks old – diarrhoea lasts 4-5 days
  • Less than 10 weeks old – diarrhoea lasts 2-10 days
  • Less than 2 weeks old – diarrhoea lasts 2-10 days
  • Around 7 months old- diarrhoea lasts 4-5 days

Pregunta 8

Pregunta
How is Bovine coronavirus diarrhoea transmitted?
Respuesta
  • Faecal–oral route of transmission
  • Droplet transmission
  • Vector transmission
  • Venereal transmission
  • Fomite transmission

Pregunta 9

Pregunta
The bovine coronavirus replicates in mature small intestinal epithelial cells, what does this effect?
Respuesta
  • Fluid absorption and digestion of disaccharides is reduced
  • Build up of fibrosis tissue due to damage, resulting in gut motility being reduced
  • Fluid absorption and digestion of fats is reduced
  • Fluid absorption increases causing oedema

Pregunta 10

Pregunta
Match the correct virus to it's epidemiology and clinical signs
Respuesta
  • Por Haemagglutinating Encephalomyelitis
  • Transmissible Gastroenteritis Virus
  • Porcine Epidemic Diarrhoea
  • Porcine Respiratory Coronavirus

Pregunta 11

Pregunta
What is thought to be a mutant of Feline enteric coronaviruses (FECV)?
Respuesta
  • Feline infectious peritonitis virus (FIPV)
  • Feline panleukopaenia
  • Feline Herpesvirus
  • Feline adenovirus

Pregunta 12

Pregunta
How do FIPV and FECV differ?
Respuesta
  • FECV causes a mild or inapparent enteritis while FIPV is a sporadic, fatal disease of young cats
  • FIPV causes a mild or inapparent enteritis while FECVV is a sporadic, fatal disease of young cats
  • FECV is always asymptomatic in domestic cats while FIPV is a sporadic, fatal disease of young cats
  • FIPV is always asymptomatic in domestic cats while FECV is a sporadic, fatal disease of young cats

Pregunta 13

Pregunta
What is the epidemiology of FIPV?
Respuesta
  • Occurs sporadically in multi-cat households or catteries
  • Cats of any age may be affected: Less than one year or older than ten are most susceptible
  • Occurs endemically to only Australia and the USA
  • Occurs only in female cats
  • Occurs only in adult cats

Pregunta 14

Pregunta
How is FIPV transmitted?
Respuesta
  • Shed in faeces and oronasal secretions, transmission by inhalation, or ingestion
  • Shed in urine, transmission ingestion
  • Shed in papules on the skin, transmission by direct contact
  • Transmission by vectors

Pregunta 15

Pregunta
In infected households ~ 15% of cats are persistently infected with FIPV
Respuesta
  • True
  • False

Pregunta 16

Pregunta
What is true of the pathogenesis of FIP?
Respuesta
  • Infection does not always result in disease
  • FECV infection sensitises cats to FIPV as antibody enhances uptake by macrophages`
  • Most infected kittens develop an effective cell-mediated immune response and eliminate the virus
  • Generally infected kittens develop the severe form of the disease due to lacking a mature immune system
  • FIP causes disease 90% of the time when an animal becomes infected

Pregunta 17

Pregunta
What happens after FIP exposure?

Pregunta 18

Pregunta
Infectious bronchitis is a highly contagious, economically important disease of chickens worldwide
Respuesta
  • True
  • False

Pregunta 19

Pregunta
What is the pathogenesis of infectious beonchitis?
Respuesta
  • Respiratory system is the site of primary replication
  • Virus distributed widely – oviducts, kidneys and Bursa severity of lesions determined by strain virulence
  • Viraemia within 1-2 days of exposure
  • Gastrointestinal system is the site of primary replication
  • Viraemia within 5-7 days of exposure
  • 48 hour incubation
  • 72 hour incubation

Pregunta 20

Pregunta
How is infectious bronchitis spread?
Respuesta
  • Primarily respiratory transmission by aerosol (shed from respiratory tract for several weeks) and recovered from faeces and eggs
  • Primarily faecal-oral route
  • Vector transmission
  • Venereal transmission

Pregunta 21

Pregunta
In what age group are the clinical signs of infectious bronchitis the most severe?
Respuesta
  • In young birds
  • In adult birds
  • In aged birds
  • In embryos, causing death

Pregunta 22

Pregunta
What are the clinical signs of infectious bronchitis?
Respuesta
  • Rales and gasping in older birds
  • Reduced egg production
  • In animals <3weeks there is gasping, nasal exudate and can result in mortality from occluded bronchi
  • Disease symptoms for 7 days in individuals
  • Disease symptoms for 10 – 14 days in flock
  • Disease symptoms for 20 – 25 days in flock
  • Disease symptoms for 14 days in individuals

Pregunta 23

Pregunta
How is infectious bronchitis diagnosed?
Respuesta
  • Virus isolation (egg inoculation) and serology (neutralisation, ELISA, HI)
  • Virus isolation (egg inoculation) and bacterial culture
  • Bacterial culture and PCR
  • Physical examination

Pregunta 24

Pregunta
Is there a vaccine available to prevent infectious bronchitis?
Respuesta
  • Yes, live and killed vaccines are available
  • Yes, a live vaccine is available only
  • No vaccines are available
  • A vaccine was available until the virus mutated in 2015

Pregunta 25

Pregunta
How are coronaviruses spread?
Respuesta
  • Inhalation and ingestion - faecal oral route or via aerosol
  • Fomite spread
  • Vector borne transmission
  • Ingestion- oral route

Pregunta 26

Pregunta
How contagious are Coronaviruses?
Respuesta
  • Variable (depending on the virus)
  • Not contagious but are infectious
  • Highly contagious

Pregunta 27

Pregunta
What is the basic structure of togaviridae?
Respuesta
  • Enveloped ss + sense RNA viruses with an Icosahedral capsid
  • Non-enveloped ss + sense RNA viruses with an Icosahedral capsid
  • Enveloped ds + sense RNA viruses with an Icosahedral capsid
  • Enveloped ss - sense RNA viruses with an Icosahedral capsid
  • Non-enveloped ss - sense RNA viruses with an Icosahedral capsid

Pregunta 28

Pregunta
Which two genera belong to Togaviridae?
Respuesta
  • Rubivirus
  • Alphavirus
  • Orbivirus
  • Torovirus

Pregunta 29

Pregunta
Where is Equine encephalitides found?
Respuesta
  • Confined to Western hemisphere
  • Confined to the Northern hemisphere
  • Confined to Europe
  • Confined to the Southern hemisphere

Pregunta 30

Pregunta
What is true of the epidemiology of Equine encephalitides?
Respuesta
  • Peak periods of disease when climate favours maximum vector numbers (Late Summer after heavy rainfall)
  • Eastern and Western Equine Encephalitis – maintained in cycles involving mosquito vector and passerine birds
  • Can infect humans
  • Horses can act as amplifying hosts
  • Vector transmission in mosquitos
  • Primary resevoir is passerine birds

Pregunta 31

Pregunta
What is correct of the pathogenesis of Equine encephalitides?
Respuesta
  • Secondary replication in these tissues leads to secondary viraemia of high titre to allow CNS invasion
  • Neural necrosis, mononuclear infiltration with perivascular cuffing and interstitial oedema (VEE also involves respiratory tract)
  • Primary viraemia allows spread to muscle and connective tissues and reticuloendothelial system
  • Replication in local cells - drain to regional lymph nodes
  • Primary replication is in the respiratory system

Pregunta 32

Pregunta
What is the incubation period for Equine encephalitides?
Respuesta
  • up to 9 days
  • up to 13 days
  • up to 2 days
  • up to 21 days

Pregunta 33

Pregunta
What clinical signs might you see during Equine encephalitides infection?
Respuesta
  • Low carriage of head with wide base stance
  • Terminal recumbency
  • Range from mild fever and depression to fatal febrile encephalomyelitis
  • CNS signs: photophobia, head pressing, circling, ataxia, blindness, inability to swallow
  • Diarrhoea
  • Oronasal discharge

Pregunta 34

Pregunta
Viraemia is transient and so isolation from blood is relatively easy
Respuesta
  • True
  • False

Pregunta 35

Pregunta
How might you control Equine encephalitides?
Respuesta
  • Vector control (insecticides, repellent, insect proof stabling)
  • Vaccination available in endemic areas
  • Antivirals
  • Infertile male mosquitos

Pregunta 36

Pregunta
What are Arboviruses?
Respuesta
  • Arthropod borne viruses. “Viruses that replicate in their haematophagous arthropod hosts and transmitted to vertebrate host by biting”
  • Arboviruses – Arachnid borne viruses. “Viruses that replicate in their haematophagous arachnid hosts and transmitted to vertebrate host by biting”
  • Amphibian borne viruses. “Viruses that replicate in their haematophagous amphibian hosts and transmitted to vertebrate host by biting”
  • Aquatic borne viruses. “Viruses that replicate in their haematophagous aquatic hosts and transmitted to vertebrate host by biting”

Pregunta 37

Pregunta
Which Arbovirses are endemic to Australia?
Respuesta
  • Ross River virus (Family Togaviridae) people, horses
  • Murray Valley encephalitis virus (Family Flaviviridae) people, horses
  • Kunjin / WNV (Family Flaviviridae) person, horses ?dogs, donkey, alpacca?
  • Japanese encephalitis virus (Family Flaviviridae)

Pregunta 38

Pregunta
Which arboviral disease is the commonest, most widespread reported in Australia>
Respuesta
  • Ross River Virus
  • Murray Valley encephalitis virus
  • Kunjin virus / West Nile virus
  • Japanese encephalitis virus

Pregunta 39

Pregunta
What is the basic structure of Flaviviridae?
Respuesta
  • Enveloped, ss + sense RNA viruses
  • Non-enveloped, ss + sense RNA viruses
  • Enveloped, ds + sense RNA viruses
  • Enveloped, ss - sense RNA viruses

Pregunta 40

Pregunta
Mature Flaviviridae virions are quite labile: sensitive to heat, detergents, common disinfectants
Respuesta
  • True
  • False

Pregunta 41

Pregunta
What is interesting about Classical Swine Fever?
Respuesta
  • Stable in meat products for weeks/months. Enabled re-introduction and spread
  • Stable in the air for weeks/months. Enabled re-introduction and spread
  • Not stable in the environment, reintroduction occurred with an accidental release from a laboratory in Germany
  • Stable in milk products for weeks/months. Enabled re-introduction and spread

Pregunta 42

Pregunta
What genera belong to Flaviviridae?
Respuesta
  • Flavivirus
  • Pestivirus
  • Hepacivirus
  • Alphavirus
  • Rubivirus

Pregunta 43

Pregunta
What is the pathogenesis of Flaviviridae?
Respuesta
  • Bite from infected arthropod-->Viraemia-->Dissemination to target organs (endothelium, liver, foetus, CNS)
  • Bite from infected arthropod-->Local virus replication-->Viraemia-->Dissemination to target organs (endothelium, liver, foetus, CNS)
  • Bite from infected arthropod-->Local virus replication-->Viraemia-->Dissemination to the heart

Pregunta 44

Pregunta
What is correct of Japanese Encephalitis epidemiology?
Respuesta
  • Pigs are important amplifying hosts
  • Water birds are the main reservoir host
  • Endemic in South-East Asia (spreading West and South)
  • Infections in humans and horses (dead end hosts) often cause severe and fatal encephalitis
  • Inapparent infections in other species
  • Pigs are dead end hosts
  • Pigs are the main reservoir host
  • Water birds are dead end hosts

Pregunta 45

Pregunta
What clinical signs does Japanese encephalitis cause in pigs?
Respuesta
  • Reproductive failure (abortion, stillbirths, weak young, otherwise inapparent infection of young)
  • Fever, Lethargy and Recovery or Hyperexcitable and Death
  • GIT dysfunction
  • Total organ necrosis

Pregunta 46

Pregunta
What clinical signs does Japanese Encephalitis cause in horses?
Respuesta
  • Reproductive failure (abortion, stillbirths, weak young, otherwise inapparent infection of young)
  • Fever, Lethargy and Recovery or Hyperexcitable and Death
  • GIT dysfunction
  • Respiratory disease (oronasal discharge)

Pregunta 47

Pregunta
West Nile Virus can cause (fatal) encephalitis in horses and haemorrhagic fever in humans
Respuesta
  • True
  • False

Pregunta 48

Pregunta
Where can West Nile Virus be found?
Respuesta
  • Occurs throughout the Mediterranean, Asia and Africa
  • The United States
  • Australia
  • Antarctica

Pregunta 49

Pregunta
What is the difference between the acute and chronic forms of bovine virus diarrhoea (BVD)?
Respuesta
  • Acute disease – bovine virus diarrhoea Chronic disease – mucosal disease (persistent infection)
  • Acute disease –mucosal disease (persistent infection) Chronic disease – bovine virus diarrhoea
  • Acute disease – death Chronic disease – mucosal disease (persistent infection)
  • Acute disease – bovine virus diarrhoea Chronic disease – Asymptomatic shedding

Pregunta 50

Pregunta
What happens when a pregnant cow is infected with BVD vs. a non-pregnant cow?
Respuesta
  • Infection of susceptible adult cattle usually of little consequence unless pregnant (transplacental spread common)
  • Asymptomatic infection in the feotus
  • Abortion of the feotus if infection late in gestation (> 125 days)

Pregunta 51

Pregunta
[blank_start]Infection early in gestation(< 80[blank_end] days)-- Abortion, mummification, early embryonic death and resorption [blank_start]Infection late in gestation (> 125[blank_end] days)--Mount active immune response Develop antibody and survive (+/- some pathology) [blank_start]Infection early in gestation (80-125[blank_end] days)-- Cytopathic strain of BVDV Foetal lesions, weak or dead calves Non-cytopathic strain = tolerance
Respuesta
  • Infection early in gestation (80-125
  • Infection late in gestation (> 125
  • Infection early in gestation (< 80
  • Infection late in gestation (<80

Pregunta 52

Pregunta
What are the symptoms of mucosal BVD?
Respuesta
  • Profuse watery diarrhoea, Nasal discharge, salivation Ulcerative lesions, death
  • CNS dysfunction, death
  • Heart failure
  • Asymptomatic

Pregunta 53

Pregunta
How can BVD be diagnosed?
Respuesta
  • Isolate virus / detect virus antigens (3 cultures),
  • Serology (4 fold increase in neutralising titre)
  • Immunofluorescence on smears of tissue
  • ELISA
  • Bacterial culture

Pregunta 54

Pregunta
How do you control Bovine Viral Diarrhoea?
Respuesta
  • Remove persistently infected animals (source of virus)
  • Vaccinations (although not fully protective)
  • Cull all animals when one is found with BVD
  • Utilise disinfectants in sheds and places where animals frequent

Pregunta 55

Pregunta
Which of the below relate to classical Swine Fever?
Respuesta
  • Strains with low virulence – reduced fertility
  • Moderate strains – more chronic disease
  • Convulsions, sudden death Posterior paresis, paralysis, circling, tremors and death within weeks
  • Fever, hyperaemia, purpura
  • Highly contagious exotic disease
  • 2-10 day incubation

Pregunta 56

Pregunta
How is classical swine fever transmitted?
Respuesta
  • Ingestion and inhalation
  • Vector/arbovirus transmission
  • Venereal transmission
  • Fomite spread

Pregunta 57

Pregunta
Where does classical swine fever replicate?
Respuesta
  • In tonsils, spread to lymph and endothelial cells
  • In epithelial cells
  • In the GIT

Pregunta 58

Pregunta
What does CSF cause?
Respuesta
  • Haemorrhages, DIC, thrombosis of small vessels
  • CNS dysfunction
  • Reproductive dysfunction
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