Pregunta 1
Pregunta
What genera belong to the family Coronaviridae?
Respuesta
-
Torovirus
-
Coronavirus
-
Orbivirus
-
Rotavirus
Pregunta 2
Pregunta
What is interesting about the coronavirus genera?
Respuesta
-
They cause a wide variety of clinical disease
-
The virus is highly stable in the environment, surviving years without a host
-
The virus is resistant to pH
-
The virus causes latent infection
Pregunta 3
Pregunta
What clinical symptoms do coronaviruses cause?
Respuesta
-
Enteric
-
Neurological
-
Respiratory
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Immunological
Pregunta 4
Pregunta
What is the basic structure of coronaviridae?
Respuesta
-
Non-enveloped, spherical, single stranded positive sense RNA
-
Enveloped, spherical, single stranded positive sense RNA
-
Enveloped, spherical, single stranded DNA
-
Enveloped, spherical, double stranded positive sense RNA
-
Non-enveloped, spherical, double stranded positive sense RNA
Pregunta 5
Pregunta
What areas of the body does the coronaviridae have a "tropism" for?
Respuesta
-
Respiratory and/or gastrointestinal epithelium
-
Respiratory and/or myocaridal epithelium
-
Bone marrow and lymph nodes
-
Respiratory and/or circulatory system endothelium
Pregunta 6
Pregunta
Why is Bovine Coronavirus Diarrhoea important?
Respuesta
-
Second most common cause of diarrhoea in calves
-
Most common cause of diarrhoea in calves
-
Most common cause of abortions in cattle
-
Leads to infertility in cattle
Pregunta 7
Pregunta
When are calves most likely to be affected by Bovine coronavirus diarrhoea?
Respuesta
-
Less than 2 weeks old – diarrhoea lasts 4-5 days
-
Less than 10 weeks old – diarrhoea lasts 2-10 days
-
Less than 2 weeks old – diarrhoea lasts 2-10 days
-
Around 7 months old- diarrhoea lasts 4-5 days
Pregunta 8
Pregunta
How is Bovine coronavirus diarrhoea transmitted?
Pregunta 9
Pregunta
The bovine coronavirus replicates in mature small intestinal epithelial cells, what does this effect?
Respuesta
-
Fluid absorption and digestion of disaccharides is reduced
-
Build up of fibrosis tissue due to damage, resulting in gut motility being reduced
-
Fluid absorption and digestion of fats is reduced
-
Fluid absorption increases causing oedema
Pregunta 10
Pregunta
Match the correct virus to it's epidemiology and clinical signs
Respuesta
-
Por Haemagglutinating Encephalomyelitis
-
Transmissible Gastroenteritis Virus
-
Porcine Epidemic Diarrhoea
-
Porcine Respiratory Coronavirus
Pregunta 11
Pregunta
What is thought to be a mutant of Feline enteric coronaviruses (FECV)?
Pregunta 12
Pregunta
How do FIPV and FECV differ?
Respuesta
-
FECV causes a mild or inapparent enteritis while FIPV is a sporadic, fatal disease of young cats
-
FIPV causes a mild or inapparent enteritis while FECVV is a sporadic, fatal disease of young cats
-
FECV is always asymptomatic in domestic cats while FIPV is a sporadic, fatal disease of young cats
-
FIPV is always asymptomatic in domestic cats while FECV is a sporadic, fatal disease of young cats
Pregunta 13
Pregunta
What is the epidemiology of FIPV?
Respuesta
-
Occurs sporadically in multi-cat households or catteries
-
Cats of any age may be affected: Less than one year or older than ten are most susceptible
-
Occurs endemically to only Australia and the USA
-
Occurs only in female cats
-
Occurs only in adult cats
Pregunta 14
Pregunta
How is FIPV transmitted?
Respuesta
-
Shed in faeces and oronasal secretions, transmission by inhalation, or ingestion
-
Shed in urine, transmission ingestion
-
Shed in papules on the skin, transmission by direct contact
-
Transmission by vectors
Pregunta 15
Pregunta
In infected households ~ 15% of cats are persistently infected with FIPV
Pregunta 16
Pregunta
What is true of the pathogenesis of FIP?
Respuesta
-
Infection does not always result in disease
-
FECV infection sensitises cats to FIPV as antibody enhances uptake by macrophages`
-
Most infected kittens develop an effective cell-mediated immune response and eliminate the virus
-
Generally infected kittens develop the severe form of the disease due to lacking a mature immune system
-
FIP causes disease 90% of the time when an animal becomes infected
Pregunta 17
Pregunta
What happens after FIP exposure?
Respuesta
-
?
-
??
-
????
-
?????
-
?????????????
Pregunta 18
Pregunta
Infectious bronchitis is a highly contagious, economically important disease of chickens worldwide
Pregunta 19
Pregunta
What is the pathogenesis of infectious beonchitis?
Respuesta
-
Respiratory system is the site of primary replication
-
Virus distributed widely – oviducts, kidneys and Bursa severity of lesions determined by strain virulence
-
Viraemia within 1-2 days of exposure
-
Gastrointestinal system is the site of primary replication
-
Viraemia within 5-7 days of exposure
-
48 hour incubation
-
72 hour incubation
Pregunta 20
Pregunta
How is infectious bronchitis spread?
Pregunta 21
Pregunta
In what age group are the clinical signs of infectious bronchitis the most severe?
Pregunta 22
Pregunta
What are the clinical signs of infectious bronchitis?
Respuesta
-
Rales and gasping in older birds
-
Reduced egg production
-
In animals <3weeks there is gasping, nasal exudate and can result in mortality from occluded bronchi
-
Disease symptoms for 7 days in individuals
-
Disease symptoms for 10 – 14 days in flock
-
Disease symptoms for 20 – 25 days in flock
-
Disease symptoms for 14 days in individuals
Pregunta 23
Pregunta
How is infectious bronchitis diagnosed?
Respuesta
-
Virus isolation (egg inoculation) and serology (neutralisation, ELISA, HI)
-
Virus isolation (egg inoculation) and bacterial culture
-
Bacterial culture and PCR
-
Physical examination
Pregunta 24
Pregunta
Is there a vaccine available to prevent infectious bronchitis?
Respuesta
-
Yes, live and killed vaccines are available
-
Yes, a live vaccine is available only
-
No vaccines are available
-
A vaccine was available until the virus mutated in 2015
Pregunta 25
Pregunta
How are coronaviruses spread?
Pregunta 26
Pregunta
How contagious are Coronaviruses?
Pregunta 27
Pregunta
What is the basic structure of togaviridae?
Respuesta
-
Enveloped ss + sense RNA viruses with an Icosahedral capsid
-
Non-enveloped ss + sense RNA viruses with an Icosahedral capsid
-
Enveloped ds + sense RNA viruses with an Icosahedral capsid
-
Enveloped ss - sense RNA viruses with an Icosahedral capsid
-
Non-enveloped ss - sense RNA viruses with an Icosahedral capsid
Pregunta 28
Pregunta
Which two genera belong to Togaviridae?
Respuesta
-
Rubivirus
-
Alphavirus
-
Orbivirus
-
Torovirus
Pregunta 29
Pregunta
Where is Equine encephalitides found?
Respuesta
-
Confined to Western hemisphere
-
Confined to the Northern hemisphere
-
Confined to Europe
-
Confined to the Southern hemisphere
Pregunta 30
Pregunta
What is true of the epidemiology of Equine encephalitides?
Respuesta
-
Peak periods of disease when climate favours maximum vector numbers (Late Summer after heavy rainfall)
-
Eastern and Western Equine Encephalitis – maintained in cycles involving mosquito vector and passerine birds
-
Can infect humans
-
Horses can act as amplifying hosts
-
Vector transmission in mosquitos
-
Primary resevoir is passerine birds
Pregunta 31
Pregunta
What is correct of the pathogenesis of Equine encephalitides?
Respuesta
-
Secondary replication in these tissues leads to secondary viraemia of high titre to allow CNS invasion
-
Neural necrosis, mononuclear infiltration with perivascular cuffing and interstitial oedema (VEE also involves respiratory tract)
-
Primary viraemia allows spread to muscle and connective tissues and reticuloendothelial system
-
Replication in local cells - drain to regional lymph nodes
-
Primary replication is in the respiratory system
Pregunta 32
Pregunta
What is the incubation period for Equine encephalitides?
Respuesta
-
up to 9 days
-
up to 13 days
-
up to 2 days
-
up to 21 days
Pregunta 33
Pregunta
What clinical signs might you see during Equine encephalitides infection?
Respuesta
-
Low carriage of head with wide base stance
-
Terminal recumbency
-
Range from mild fever and depression to fatal febrile encephalomyelitis
-
CNS signs: photophobia, head pressing, circling, ataxia, blindness, inability to swallow
-
Diarrhoea
-
Oronasal discharge
Pregunta 34
Pregunta
Viraemia is transient and so isolation from blood is relatively easy
Pregunta 35
Pregunta
How might you control Equine encephalitides?
Respuesta
-
Vector control (insecticides, repellent, insect proof stabling)
-
Vaccination available in endemic areas
-
Antivirals
-
Infertile male mosquitos
Pregunta 36
Pregunta
What are Arboviruses?
Respuesta
-
Arthropod borne viruses.
“Viruses that replicate in their haematophagous arthropod hosts and transmitted to vertebrate host by biting”
-
Arboviruses – Arachnid borne viruses.
“Viruses that replicate in their haematophagous arachnid hosts and transmitted to vertebrate host
by biting”
-
Amphibian borne viruses.
“Viruses that replicate in their haematophagous amphibian hosts and transmitted to vertebrate host by biting”
-
Aquatic borne viruses.
“Viruses that replicate in their haematophagous aquatic hosts and transmitted to vertebrate host by biting”
Pregunta 37
Pregunta
Which Arbovirses are endemic to Australia?
Respuesta
-
Ross River virus (Family Togaviridae) people, horses
-
Murray Valley encephalitis virus (Family Flaviviridae) people, horses
-
Kunjin / WNV (Family Flaviviridae) person, horses ?dogs, donkey, alpacca?
-
Japanese encephalitis virus (Family Flaviviridae)
Pregunta 38
Pregunta
Which arboviral disease is the commonest, most widespread reported in Australia>
Respuesta
-
Ross River Virus
-
Murray Valley encephalitis virus
-
Kunjin virus / West Nile virus
-
Japanese encephalitis virus
Pregunta 39
Pregunta
What is the basic structure of Flaviviridae?
Respuesta
-
Enveloped, ss + sense RNA viruses
-
Non-enveloped, ss + sense RNA viruses
-
Enveloped, ds + sense RNA viruses
-
Enveloped, ss - sense RNA viruses
Pregunta 40
Pregunta
Mature Flaviviridae virions are quite labile: sensitive to heat, detergents, common disinfectants
Pregunta 41
Pregunta
What is interesting about Classical Swine Fever?
Respuesta
-
Stable in meat products for weeks/months. Enabled re-introduction and spread
-
Stable in the air for weeks/months. Enabled re-introduction and spread
-
Not stable in the environment, reintroduction occurred with an accidental release from a laboratory in Germany
-
Stable in milk products for weeks/months. Enabled re-introduction and spread
Pregunta 42
Pregunta
What genera belong to Flaviviridae?
Respuesta
-
Flavivirus
-
Pestivirus
-
Hepacivirus
-
Alphavirus
-
Rubivirus
Pregunta 43
Pregunta
What is the pathogenesis of Flaviviridae?
Respuesta
-
Bite from infected arthropod-->Viraemia-->Dissemination to target organs (endothelium, liver, foetus, CNS)
-
Bite from infected arthropod-->Local virus replication-->Viraemia-->Dissemination to target organs (endothelium, liver, foetus, CNS)
-
Bite from infected arthropod-->Local virus replication-->Viraemia-->Dissemination to the heart
Pregunta 44
Pregunta
What is correct of Japanese Encephalitis epidemiology?
Respuesta
-
Pigs are important amplifying hosts
-
Water birds are the main reservoir host
-
Endemic in South-East Asia (spreading West and South)
-
Infections in humans and horses (dead end hosts) often cause severe and fatal encephalitis
-
Inapparent infections in other species
-
Pigs are dead end hosts
-
Pigs are the main reservoir host
-
Water birds are dead end hosts
Pregunta 45
Pregunta
What clinical signs does Japanese encephalitis cause in pigs?
Respuesta
-
Reproductive failure (abortion, stillbirths, weak young, otherwise inapparent infection of young)
-
Fever, Lethargy and Recovery or Hyperexcitable and Death
-
GIT dysfunction
-
Total organ necrosis
Pregunta 46
Pregunta
What clinical signs does Japanese Encephalitis cause in horses?
Respuesta
-
Reproductive failure (abortion, stillbirths, weak young, otherwise inapparent infection of young)
-
Fever, Lethargy and Recovery or Hyperexcitable and Death
-
GIT dysfunction
-
Respiratory disease (oronasal discharge)
Pregunta 47
Pregunta
West Nile Virus can cause (fatal) encephalitis in horses and haemorrhagic fever in humans
Pregunta 48
Pregunta
Where can West Nile Virus be found?
Pregunta 49
Pregunta
What is the difference between the acute and chronic forms of bovine virus diarrhoea (BVD)?
Respuesta
-
Acute disease – bovine virus diarrhoea
Chronic disease – mucosal disease (persistent infection)
-
Acute disease –mucosal disease (persistent infection)
Chronic disease – bovine virus diarrhoea
-
Acute disease – death
Chronic disease – mucosal disease (persistent infection)
-
Acute disease – bovine virus diarrhoea
Chronic disease – Asymptomatic shedding
Pregunta 50
Pregunta
What happens when a pregnant cow is infected with BVD vs. a non-pregnant cow?
Respuesta
-
Infection of susceptible adult cattle usually of little consequence unless pregnant (transplacental spread common)
-
Asymptomatic infection in the feotus
-
Abortion of the feotus if infection late in gestation (> 125 days)
Pregunta 51
Pregunta
[blank_start]Infection early in gestation(< 80[blank_end] days)-- Abortion, mummification, early embryonic death and resorption
[blank_start]Infection late in gestation (> 125[blank_end] days)--Mount active immune response Develop antibody and survive (+/- some pathology)
[blank_start]Infection early in gestation (80-125[blank_end] days)-- Cytopathic strain of BVDV Foetal lesions, weak or dead calves Non-cytopathic strain = tolerance
Respuesta
-
Infection early in gestation (80-125
-
Infection late in gestation (> 125
-
Infection early in gestation (< 80
-
Infection late in gestation (<80
Pregunta 52
Pregunta
What are the symptoms of mucosal BVD?
Pregunta 53
Pregunta
How can BVD be diagnosed?
Respuesta
-
Isolate virus / detect virus antigens (3 cultures),
-
Serology (4 fold increase in neutralising titre)
-
Immunofluorescence on smears of tissue
-
ELISA
-
Bacterial culture
Pregunta 54
Pregunta
How do you control Bovine Viral Diarrhoea?
Respuesta
-
Remove persistently infected animals (source of virus)
-
Vaccinations (although not fully protective)
-
Cull all animals when one is found with BVD
-
Utilise disinfectants in sheds and places where animals frequent
Pregunta 55
Pregunta
Which of the below relate to classical Swine Fever?
Respuesta
-
Strains with low virulence – reduced fertility
-
Moderate strains – more chronic disease
-
Convulsions, sudden death Posterior paresis, paralysis, circling, tremors and death within weeks
-
Fever, hyperaemia, purpura
-
Highly contagious exotic disease
-
2-10 day incubation
Pregunta 56
Pregunta
How is classical swine fever transmitted?
Pregunta 57
Pregunta
Where does classical swine fever replicate?
Pregunta 58
Pregunta
What does CSF cause?