Natural Products

In specimen collection the plant must be dried and kept sterile to minimise damage

Which of the following is best to aid identification of the natural product/plant

macerated leaves are treated with chemicals that gradually decrease in polarity to extract chemicals

General screening bioassays are [blank_start]simple[blank_end], [blank_start]inexpensive[blank_end] and used for [blank_start]rapid screening[blank_end] of extracts

specialised screening bioassays are [blank_start]subcellular[blank_end] assays directed at [blank_start]specific[blank_end] enzymes or receptors. Compounds working by mechanisms unrelated to the assay are likely to be missed.

which of the following is FALSE

crown gall tumour inhibition tests use potatoes to measure inhibition of growth

which 3 do starfish or sea urchin assays allow detection of?

which best applies to an agar dilution streak assay?

Which tlc staining technique is used to test acidic groups

which one of the following is not considered in NP isolation or synthesis

What are the stages of natural product processing? [blank_start]Specimen[blank_end] collection, establishing [blank_start]taxonomy[blank_end], extracting possible active molecules, using [blank_start]screening[blank_end] techniques to evaluate therapeutic activity, identifying and [blank_start]isolating[blank_end] the structure responsible for the activity, using organic synthesis

a range of techniques are used to isolate active compounds (fractionation). these include [blank_start]TLC[blank_end], column chromatography, [blank_start]HPLC[blank_end] and combinations such as HPLC/MS