7990396
Pregunta 1
Pregunta
By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?
Respuesta
-
1
-
2
-
3
Pregunta 2
Pregunta
The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?
Respuesta
-
Solid state
-
Particle size
-
Molecular weight
-
Chemical structure
Pregunta 3
Pregunta
Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?
Respuesta
-
To increase the solubility
-
To mask bitter tastes
-
To increase the viscosity
-
To decrease the viscosity
-
None of the above
Pregunta 4
Pregunta
Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?
Respuesta
-
Factor of 1/2
-
Factor of 2
-
Factor of 4
Pregunta 5
Pregunta
Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?
Respuesta
-
The viscosity would be infinite
-
The settling rate will be very high
-
The settling rate would be zero
-
The particle size would approach colloidal dimensions
Pregunta 6
Pregunta
The primary mechanism of altering dispersion medium properties is modification of:
Respuesta
-
Density
-
Viscosity
-
Dielectric constant
Pregunta 7
Pregunta
Which of the following characteristics is NOT desirable in the case of suspension dosage forms?
Respuesta
-
Flocculation with formulation of loosely bound aggregates
-
Flocculation with formulation of strongly bound aggregates
-
Formation of loose sediment
Pregunta 8
Pregunta
An advantage of a shear thinning formulation includes:
Respuesta
-
Ease of mixing with relatively mild shaking of the container
-
Lower viscosity on standing to prevent settling
-
Caking of needle shaped particles
Pregunta 9
Pregunta
Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?
Respuesta
-
Only for acute usage
-
Only for antibiotics
-
Never
Pregunta 10
Pregunta
You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?
Respuesta
-
You can save the effort and advise the patient they must wait until you can order the commercial dosage form
-
If a commercial liquid dosage form isn’t available, it may indicate a potential chemical stability problem
-
If a commercial liquid dosage form isn’t available, it may indicate a potential physical stability problem
-
Both B and C
Pregunta 11
Pregunta
Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.
Respuesta
-
1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
-
1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH
-
1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
-
All of the above
Pregunta 12
Pregunta
Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?
Respuesta
-
Dispersed phase tends to form aggregates of globules on standing
-
Aggregates of the dispersed phase may be re-dispersed by shaking
-
Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase
-
All or part of the liquid in the dispersed phase separates to form a distinct layer
Pregunta 13
Pregunta
Patients should virtually never be instructed to store an emulsion dosage form:
Respuesta
-
In the refrigerator
-
At room temperature
-
In the freezer
Pregunta 14
Pregunta
The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):
Respuesta
-
72 and 28% respectively
-
28 and 72% respectively
-
None of the above
Pregunta 15
Pregunta
A magma is a:
Respuesta
-
Two phase gel in which the gel mass does not consists of floccules of small distinct particles
-
One phase gel in which the gel mass consists of floccules of small distinct particles
-
Two phase gel in which the gel mass consist of floccules of small distinct particles
Pregunta 16
Pregunta
In a colloidal dispersion the particle size is:
Respuesta
-
Much smaller than typical molecule dimensions
-
Much larger than typical molecule dimensions
-
The same or smaller than typical molecule dimensions
Pregunta 17
Pregunta
Which of following is FALSE in case of gel formulation exhibiting syneresis?
Respuesta
-
A measurable increase in volume of Gel
-
A non-measurable change in the volume of Gel
-
A measureable decrease in volume of Gel
-
A and B
-
B and C
Pregunta 18
Pregunta
What is a major function of glycerin in the carboxymethylcellulose based gel formulations?
Respuesta
-
To prevent drying of Gel
-
Sweetner
-
Antioxidant
Pregunta 19
Pregunta
Which of following if true of aerosol used to provide an airborne mist?
Respuesta
-
Particle size >50μm
-
Particle size <50 μm
-
Particle size <1μm
-
None of above
Pregunta 20
Pregunta
A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container
Respuesta
- True
- False
Pregunta 21
Pregunta
Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?
Respuesta
-
Preservative
-
Glycerin
-
Alcohol
-
None of the above
Pregunta 22
Pregunta
Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?
Respuesta
-
Creaming
-
Coalescence of droplets
-
Flocculation
-
None of the above
Pregunta 23
Pregunta
Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?
Respuesta
-
O/W
-
W/O
-
None of the above
Pregunta 24
Pregunta
When you decrease the particle size of disperse phase by factor of 10, then the settling velocity will decrease by a factor of:
Respuesta
-
10
-
100
-
1000
Pregunta 25
Pregunta
What is a primary reason to formulate the powders for suspension?
Respuesta
-
To facilitate transport and ease of administration
-
Maintain the stability of API
-
Improve patient compliance
¿Quieres crear tus propios Tests gratis con GoConqr? Más información.