14036348
| Pregunta | Respuesta |
| Trade names | Ampicyn - Ibimycin - Austrapen |
| Chemical name | Aminobenzylpenicillin |
| Therapeutic class | anti-infective |
| Pharmacological class | antibiotic- penicillin |
| Indications | Chronic bronchitis CAP (community acquired pneumonia) Gonnococal infection Broad spectrum |
| Actions | Bactericidal; interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death. |
| Pharmacokinetics (absorption) | Not well absorbed in GIT - best given IV for absorption |
| Distribution | Does cross placenta and enter breast milk - however is reportedly safe according to AMH |
| Metabolism & excretion | partially metabolised in the liver, with the remainder of the drug excreted through the kidneys in urine |
| Contraindications & precautions | Penicillin allergy! Those with heart failure or on sodium restriction - high levels of sodium Immunocompromised individuals = high incidence of rash Renal impairment |
| Adverse reactions | Skin: rash GIT: diarrhoea, N + V, CNS: neurotoxicity at high doses/ renal impairment |
| Assessment requirements | Obtain specimen for culture Baseline vital signs Monitor person's response to administration |
| Education | Tell patients to report adverse effects and the drink lots of fluids, and keep up nutrition. |
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