Glyceryl Trinitrate (GTN)

Descripción

Fichas sobre Glyceryl Trinitrate (GTN), creado por Em J el 04/06/2018.
Em J
Fichas por Em J, actualizado hace más de 1 año
Em J
Creado por Em J hace más de 6 años
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Resumen del Recurso

Pregunta Respuesta
Trade names (at least 4) Anginine - Lycinate - Minitran - Nitrodur - Nitrolingual spray - Nitrostat
Therapeutic class Antianginal
Pharmaceutical class Nitrate
Indications Acute angina Angina prophylaxis Hypertension assoc. post-surgery
Action Reduces oxygen demand on the heart by reducing pre-load Increases coronary blood flow
Therapeutic effects Decreases BP and decreases pain assoc. with angina
Absorption Easily absorbed dermally & sublingually - however PO does have a first pass effect and isn’t completely absorbed into the bloodstream
Metabolism & excretion Metabolised by the liver and excreted by the kidneys
Half-life three minutes
Contraindications & precautions Hypovolaemia Raised intracranial pressure Significant anemia Wear gloves when applying GTN patch
Adverse reactions CVS: Hypotension, palpitation, peripheral oedema, tachycardia CNS: Headache (treat w/ aspirin), dizziness, weakness GIT: N & V SKIN: rash
Interactions Combined with antihypertensives can create an increased hypotensive effect Alcohol use can lead to increased hypotension
Nursing assessments BP Monitor vital signs Pain assessment if required
Education Caution pt to take drug as prescribed - discontinuation may cause coronary vasospasms - Tell PT to take drug at first sign of chest pain - Tablet needs to be held under tongue - ineffective if swallowed - If pain persists after 10 minutes following 2 doses and rest - seek emergency med. Attention
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