Citric Acid Cycle

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Fichas sobre Citric Acid Cycle, creado por Kara Robbins el 21/06/2015.
Kara Robbins
Fichas por Kara Robbins, actualizado hace más de 1 año
Kara Robbins
Creado por Kara Robbins hace más de 9 años
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Pregunta Respuesta
What is the Citric Acid Cycle (CAC) also known as, and where does it occur? The Citric Acid Cycle is also known as the Krebs Cycle, and occurs in the inner mitochondrial matrix.
What steps link glycolysis to the Citric Acid Cycle? What molecule enters and what is produced? Pyruvate Dehydrogenase Complex (PDH) connects glycolysis and CAC. Pyruvate enters and 1 Acetyl CoA and 1 NADH is produced.
How many NADH, FADH2, and GTP are produced in the CAC per Acetyl CoA (per glucose molecule)? 6 NADH 2 FADH2 2 GTP
How many ATPs can be produced at the ETC from each NADH and FADH2? How is this different from the NADH produced in glycolysis? NADH can produce 3 ATP at the ETC FADH2 can produce 2 ATP at the ETC. In glycolysis, NADH & FADH2 produce 2 ATP only.
How many steps are there in the CAC, and how to the first and last steps link? There are 8 steps, and the first step (Acetyl CoA) requires the last step (oxaloacatate) to be able to start the Cycle.
What happens in step 1? Acetyl CoA enters the cycle, is catalyzed by citrate synthase and becomes citrate.
What happens in step 2? Citrate becomes isocitrate.
What happens in step 3? Isocitrate becomes alpha-ketaglutarate (1 NADH is produced), catalyzed by isocitrate dehydrogenase. Co2 is produced as waste.
What happens in step 4? Alpha-ketaglutarate becomes succinyl-CoA. 1 NADH is produced. Co2 is produced as waste.
What happens in step 5? Succinyl-CoA becomes succinate. 1 GTP is produced.
What happens in step 6? Succinate becomes fumarate. 1 FADH2 is produced.
What happens in step 7? Fumarate becomes malate.
What happens in step 8? Malate becomes oxaloacetate, and 1 NADH is produced. Oxaloacetate then goes onto Acetyl CoA to continue the cycle.
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