Sympathomimetics: organ effects

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Pharmacology - Bio 528
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Arterial blood vessels: most systemic vessels Alpha-1 = vasoconstriction (increased SVR)
Arterial blood vessels: skeletal muscle vessels Beta-2 = vasodilation (decreased SVR)
SA node Beta-1 = increased heart rate
AV node beta-1 = increased conduction speed
heart: muscle fibers beta-1 = increased contractility
lung: bronchiolar muscle beta-2 = bronchodilation
Lungs: secretory glands Beta-2: increased secretions
kidney (1 of 2) beta-1: increased renin release
Kidney (2 of 2) Alpha-1: decreased renin release
Liver Beta-2: glycogenolysis & gluconeogenesis
Uterus relaxation Beta-2
Uterus contraction Alpha-1
Na+/K+ pump Beta-2 = stimulates Na+/K+ pump (decreases plasma K+)
veins alpha-1 = vasoconstriction (increased preload)
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