Motor Proteins- Cytoplasmic Dyenin

Pregunta	Respuesta
Size of Cytoplasmic Dyenin	350 kDa
Dyenin Superfamily	AAA+
Direction of C.Dyenin movement	From plus end to minus end
Cargo	mRNA, proteins, viruses- it varies
Role of Multiple Light Chain	Where cargo binds
No of heavy chains	2
AAA+ domains	Form a hexameric motor domain
Role of Linker domain	Dimerises protein
Coiled coil	Links AAA+ motor heads to microtubule binding site
N-terminus	Light chains, dimerisation and cargo binding
C terminus	AAA+ motors, tubulin binding and linking coiled coil stalk
Location of ATP binding	AAA+ domains
Binding of ATP changes	Relative positions of linker domains and coiled coil
ATP binding causes _ of MTBD	Weakening of MTBD to tubulin
No of ATP req'd	Unclear
Distance moved by Dyenin heads	16nm- but it varies a lot
Largest known 'step' of head	30 nm
Backwards movement	Possible
Movement onto other microtubules	Allows it to pass kinesin (kinesin can't change M.T's)
Mutant with non-functioning ATP head	Still moved, but slowly and with no powerstroke
Co-ordination of Dyenin movement	Much less co-ordinated than kinesin
Mechanism of movement	Hand over Hand model

Resumen del Recurso

	Creado por gina_evans0312 hace alrededor de 11 años