Hodgkin Lymphoma

Pregunta	Respuesta
Lymphomas - malignant tumors of:	Primary lymphoid tissue (thymus) Secondary tissue (lymph nodes, spleen, tonsils)
Pathophysiology:	Abnormal chromosomes present in cells of lymph nodes. - Reed-Sternberg cell (RS cells) - not specific to HL Usually arises in a single node Molecular mechanisms causing malignant transformation of cells are unclear - Viruses, genetic factors
Clinical Manifestations:	1st sign: enlarged unilateral painless swelling or mass in neck. CXR shows mediastinal mass Enlargement of cervical, axillary & inguinal lymph nodes common. Fever / sweating / weight loss
Diagnosis:	May be difficult due to variety of symptoms. CXR, biopsy, lymphangiography Identify stage once diagnosis made
Treatment:	Cure possible regardless of stage (75% success rate). Chemotherapy. Radiation therapy. HIgh dose chemo w/ BM or stem cell transplant (latest Tx option)

Resumen del Recurso

	Creado por Mark George hace más de 10 años