Creado por gina_evans0312
hace más de 10 años
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Pregunta | Respuesta |
Requirements | Further genetic changes |
HPV Integration | Randomly integrates into host genome and will no longer replicate |
Aberrant Proteins | E6 & E7 |
Role of E6 | Binds to p53 and marks it for degredation & upregulates telomerase |
Role of E7 | Binds to pocket region of Rb gene and displaces its transcription factors |
Aberrant Gene Expression & Continued Growth | Makes cancer much more likely |
Levelling of E6/E7 Expression | Used to assess risk of cancer progression |
Level E6/E7 - Low | Insufficient expression for genetic alterations to accumulate |
Level E6/E7 - High | Greatest cancer risk |
HPV & Anal Cancer | V. rare, and more common in women than men |
Immunocompromised People | Most at risk for cancer |
HPV & Cervical Cancer | 99.7% of c.c. species are HPV positive |
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