128, 129 - Bugs with Exotoxins

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First Aid Fichas sobre 128, 129 - Bugs with Exotoxins, creado por Victoria Wright el 11/05/2017.
Victoria Wright
Fichas por Victoria Wright, actualizado hace más de 1 año
Victoria Wright
Creado por Victoria Wright hace más de 7 años
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Which bacteria with exotoxins inhibit protein synthesis? Corynebacterium diphtheriae Pseudomonas aeruginosa Shigella spp. Enterohemorrhagic E coli (EHEC
Inhibit protein synthesis What toxin is associated with Corynebacterium diphtheriae? Diphtheria toxina *An AB toxin
Inhibit protein synthesis What toxin is associated with Pseudomonas aeruginosa? Exotoxin A *An AB toxin
Inhibit protein synthesis What toxin is associated with Shigella spp.? Shiga toxin (ST) *An AB toxin
Inhibit protein synthesis What toxin is associated with Enterohemorrhagic E coli (EHEC)? Shiga-like toxin (SLT) *An AB toxin
Increase fluid secretion What toxin is associated with Enterotoxigenic E coli (ETEC)? Heat-labile toxin (LT) *An AB toxin Heat-stable toxin (ST)
Increase fluid secretion What toxin is associated with Bacillus anthracis? Edema toxin *An AB toxin
Increase fluid secretion What toxin is associated with Vibrio cholerae? Cholera toxin *An AB toxin
Inhibit phagocytic ability What toxin is associated with Bordetella pertussis? Pertussis toxin *An AB toxin
Inhibit release of neurotransmitter What toxin is associated with Clostridium tetani? Tetanospasmin *An AB toxin
Inhibit release of neurotransmitter What toxin is associated with Clostridium botulinum? Botulinum toxin *An AB toxin
Lyse cell membranes What toxin is associated with Clostridium perfringens? Alpha toxin
Lyse cell membranes What toxin is associated with Streptococcus pyogenes? Streptolysin O
Superantigens causing shock What toxin is associated with Staphylococcus aureus? Toxic shock syndrome toxin (TSST-1)
Superantigens causing shock What toxin is associated with Streptococcus pyogenes? Exotoxin A
Which bacteria with exotoxins Increase fluid secretion? Enterotoxigenic E coli (ETEC) Bacillus anthracis Vibrio cholerae
Which bacteria with exotoxins inhibit phagocytic ability? Bordetella pertussis
Which bacteria with exotoxins inhibit release of neurotransmitter? Clostridium tetani Clostridium botulinum
Which bacteria with exotoxins Lyse cell membranes? Clostridium perfringens Streptococcus pyogenes
Which bacteria with exotoxins are superantigens causing shock? Staphylococcus aureus Streptococcus pyogenes
What bacteria with exotoxins are associated with the following toxin? Exotoxin A Streptococcus pyogenes Pseudomonas aeruginosa
What bacteria with exotoxins are associated with the following toxin? Toxic shock syndrome toxin (TSST-1) Staphylococcus aureus
What bacteria with exotoxins are associated with the following toxin? Streptolysin O Streptococcus pyogenes
What bacteria with exotoxins are associated with the following toxin? Alpha toxin Clostridium perfringens
What bacteria with exotoxins are associated with the following toxin? Botulinum toxin Clostridium botulinum
What bacteria with exotoxins are associated with the following toxin? Tetanospasmin Clostridium tetani
What bacteria with exotoxins are associated with the following toxin? Pertussis toxin Bordetella pertussis
What bacteria with exotoxins are associated with the following toxin? Cholera toxin Vibrio cholerae
What bacteria with exotoxins are associated with the following toxin? Edema toxin Bacillus anthracis
What bacteria with exotoxins are associated with the following toxin? Heat-labile toxin (LT) Enterotoxigenic E coli (ETEC)
What bacteria with exotoxins are associated with the following toxin? Heat-stable toxin (ST) Enterotoxigenic E coli (ETEC)
What bacteria with exotoxins are associated with the following toxin? Shiga-like toxin (SLT) Enterohemorrhagic E coli
What bacteria with exotoxins are associated with the following toxin? Shiga toxin (ST) Shigella spp.
What bacteria with exotoxins are associated with the following toxin? Diphtheria toxin Corynebacterium diphtheriae
What is the mechanism for the following bacteria with exotoxins? Corynebacterium diphtheriae (Diphtheria toxin) Inactivate elongation factor (EF-2)
What is the mechanism for the following bacteria with exotoxins? Pseudomonas aeruginosa (Exotoxin A) Inactivate elongation factor (EF-2)
What is the mechanism for the following bacteria with exotoxins? Shigella spp. (Shiga toxin (ST)) Inactivate 60S ribosome by removing adenine from rRNA
What is the mechanism for the following bacteria with exotoxins? Enterohemorrhagic E coli (EHEC) (Shiga-like toxin (SLT)) Inactivate 60S ribosome by removing adenine from rRNA
What is the mechanism for the following bacteria with exotoxins? Enterotoxigenic E coli (ETEC) (Heat-labile toxin (LT)) Overactivates adenylate cyclase (increasing cAMP) leading to increased Cl− secretion in gut and H2O efflux
What is the mechanism for the following bacteria with exotoxins? Enterotoxigenic E coli (ETEC) (Heat-stable toxin (ST)) Overactivates guanylate cyclase (increases cGMP) leads to decreased resorption of NaCl and H2O in gut
What is the mechanism for the following bacteria with exotoxins? Bacillus anthracis (Edema toxin) Mimics the adenylate cyclase enzyme (increased cAMP)
What is the mechanism for the following bacteria with exotoxins? Vibrio cholerae (Cholera toxin) Overactivates adenylate cyclase (increases cAMP) by permanently activating Gs leads to increased Cl− secretion in gut and H2O efflux
What is the mechanism for the following bacteria with exotoxins? Bordetella pertussis (Pertussis toxin) Overactivates adenylate cyclase (increasing cAMP) by disabling Gi, impairing phagocytosis to permit survival of microbe
What is the mechanism for the following bacteria with exotoxins? Clostridium tetani (Tetanospasmin) Both are proteases that cleave SNARE (soluble NSF attachment protein receptor), a set of proteins required for neurotransmitter release via vesicular fusion
What is the mechanism for the following bacteria with exotoxins? Clostridium botulinum (Botulinum toxin) Both are proteases that cleave SNARE (soluble NSF attachment protein receptor), a set of proteins required for neurotransmitter release via vesicular fusion
What is the mechanism for the following bacteria with exotoxins? Clostridium perfringens (Alpha toxin) Phospholipase (lecithinase) that degrades tissue and cell membranes
What is the mechanism for the following bacteria with exotoxins? Streptococcus pyogenes (Streptolysin O) Protein that degrades cell membrane
What is the mechanism for the following bacteria with exotoxins? Streptococcus pyogenes (Exotoxin A) Binds to MHC II and TCR outside of antigen binding site to cause overwhelming release of IL-1, IL-2, IFN-γ, and TNF-α leading to shock
What is the mechanism for the following bacteria with exotoxins? Staphylococcus aureus (Toxic shock syndrome toxin (TSST-1)) Binds to MHC II and TCR outside of antigen binding site to cause overwhelming release of IL-1, IL-2, IFN-γ, and TNF-α leading to shock
What is the manifestation of the following bacteria with exotoxins? Staphylococcus aureus (Toxic shock syndrome toxin (TSST-1)) Toxic shock syndrome: fever, rash, shock; other toxins cause scalded skin syndrome (exfoliative toxin) and food poisoning (heat-stable enterotoxin)
What is the manifestation of the following bacteria with exotoxins? Streptococcus pyogenes (Exotoxin A) Toxic shock–like syndrome: fever, rash, shock; scarlet fever
What is the manifestation of the following bacteria with exotoxins? Streptococcus pyogenes (Streptolysin O) Lyses RBCs; contributes to β-hemolysis; host antibodies against toxin (ASO) used to diagnose rheumatic fever (do not confuse with immune complexes of poststreptococcal glomerulonephritis)
What is the manifestation of the following bacteria with exotoxins? Clostridium perfringens (Alpha toxin) Degradation of phospholipids leads to myonecrosis (“gas gangrene”) and hemolysis (“double zone” of hemolysis on blood agar)
What is the manifestation of the following bacteria with exotoxins? Clostridium botulinum (Botulinum toxin) Flaccid paralysis, floppy baby; toxin prevents release of stimulatory (ACh) signals at neuromuscular junctions leads to flaccid paralysis
What is the manifestation of the following bacteria with exotoxins? Clostridium tetani (Tetanospasmin) Spastic paralysis, risus sardonicus, and “lockjaw”; toxin prevents release of inhibitory (GABA and glycine) neurotransmitters from Renshaw cells in spinal cord.
The following is the manifestation of what bacteria with exotoxins? Spastic paralysis, risus sardonicus, and “lockjaw”; toxin prevents release of inhibitory (GABA and glycine) neurotransmitters from Renshaw cells in spinal cord. Clostridium tetani (Tetanospasmin)
The following is the manifestation of what bacteria with exotoxins? Flaccid paralysis, floppy baby; toxin prevents release of stimulatory (ACh) signals at neuromuscular junctions leads to flaccid paralysis Clostridium botulinum (Botulinum toxin)
What is the manifestation of the following bacteria with exotoxins? Bordetella pertussis (Pertussis toxin) Whooping cough—child coughs on expiration and “whoops” on inspiration (toxin may not actually be a cause of cough; can cause “100-day cough” in adults)
The following is the manifestation of what bacteria with exotoxins? Whooping cough—child coughs on expiration and “whoops” on inspiration (toxin may not actually be a cause of cough; can cause “100-day cough” in adults) Bordetella pertussis (Pertussis toxin)
What is the manifestation of the following bacteria with exotoxins? Vibrio cholerae (Cholera toxin) Voluminous “rice-water” diarrhea
The following is the manifestation of what bacteria with exotoxins? Voluminous “rice-water” diarrhea Vibrio cholerae (Cholera toxin)
What is the manifestation of the following bacteria with exotoxins? Bacillus anthracis (Edema toxin) Likely responsible for characteristic edematous borders of black eschar in cutaneous anthrax
The following is the manifestation of what bacteria with exotoxins? Likely responsible for characteristic edematous borders of black eschar in cutaneous anthrax Bacillus anthracis (Edema toxin)
What is the manifestation of the following bacteria with exotoxins? Enterotoxigenic E coli (ETEC) (Heat-liable toxin (LT) and Heat-stable toxin (ST) Watery diarrhea: “labile in the Air (Adenylate cyclase), stable on the Ground (Guanylate cyclase)”
The following is the manifestation of what bacteria with exotoxins? Watery diarrhea: “labile in the Air (Adenylate cyclase), stable on the Ground (Guanylate cyclase)” Enterotoxigenic E coli (ETEC) (Heat-liable toxin (LT) and Heat-stable toxin (ST))
What is the manifestation of the following bacteria with exotoxins? Enterohemorrhagic E coli (EHEC) (Shiga-like toxin (SLT)) SLT enhances cytokine release, causing HUS (prototypically in EHEC serotype O157:H7). Unlike Shigella, EHEC does not invade host cells
The following is the manifestation of what bacteria with exotoxins? SLT enhances cytokine release, causing HUS (prototypically in EHEC serotype O157:H7). Unlike Shigella, EHEC does not invade host cells Enterohemorrhagic E coli (EHEC) (Shiga-like toxin (SLT))
What is the manifestation of the following bacteria with exotoxins? Shigella spp (Shiga toxin (ST)) GI mucosal damage leads to dysentery; ST also enhances cytokine release, causing hemolyticuremic syndrome (HUS)
The following is the manifestation of what bacteria with exotoxins? GI mucosal damage leads to dysentery; ST also enhances cytokine release, causing hemolyticuremic syndrome (HUS) Shigella spp (Shiga toxin (ST))
What is the manifestation of the following bacteria with exotoxins? Pseudomonas aeruginosa (Exotoxin A) Host cell death
The following is the manifestation of what bacteria with exotoxins? Host cell death Pseudomonas aeruginosa (Exotoxin A)
What is the manifestation of the following bacteria with exotoxins? Corynebacterium diphtheriae (Diphtheria toxin) Pharyngitis with pseudomembranes in throat and severe lymphadenopathy (bull neck)
The following is the manifestation of what bacteria with exotoxins? Pharyngitis with pseudomembranes in throat and severe lymphadenopathy (bull neck) Corynebacterium diphtheriae (Diphtheria toxin)
The following is the manifestation of what bacteria with exotoxins? Degradation of phospholipids leads to myonecrosis (“gas gangrene”) and hemolysis (“double zone” of hemolysis on blood agar) Clostridium perfringens (Alpha toxin)
The following is the manifestation of what bacteria with exotoxins? Lyses RBCs; contributes to β-hemolysis; host antibodies against toxin (ASO) used to diagnose rheumatic fever (do not confuse with immune complexes of poststreptococcal glomerulonephritis Streptococcus pyogenes (Streptolysin O)
The following is the manifestation of what bacteria with exotoxins? Toxic shock syndrome: fever, rash, shock; other toxins cause scalded skin syndrome (exfoliative toxin) and food poisoning (heat-stable enterotoxin) Staphylococcus aureus (Toxic shock syndrome toxin (TSST-1))
The following is the manifestation of what bacteria with exotoxins? Toxic shock–like syndrome: fever, rash, shock; scarlet fever Streptococcus pyogenes (Exotoxin A)
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