Drug control: Thyroid, Adrenals and GH secretion

Descripción

under grad Endocrine Pharmacology Fichas sobre Drug control: Thyroid, Adrenals and GH secretion, creado por Bhavi Mistry el 15/05/2013.
Bhavi Mistry
Fichas por Bhavi Mistry, actualizado hace más de 1 año
Bhavi Mistry
Creado por Bhavi Mistry hace más de 11 años
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Resumen del Recurso

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B antagonists Treatment of CV symptoms of hyperthyroidism (decreases BP and HR)
Radio iodine (131 I-) Concentration in thyroid gland (destroys follicle cells) NOT associated with risk of tumours NOT for use in Children/Pregnant women 2-3 weeks to take effect
Tetracosactide ACTH analogue hypoglucocorticoidism
Hydrocortisone Steroid Hypoglucocorticoidism
Sermorelin Growth hormone releasing factor analogue Treatment of too little GH
Somatotropin Replacement therapy for too little GH
Octreotride, Lanperotride Somatostatin inhibitors (somatostatin inhibits GH release from anterior pituitary somatotrophs)
Mechanism of action of theyroid hormone Binds to TR and RXR which have a positive or negative effect on gene transcriptors (e.g. Increased contractility in the heart due to balance of myosin components - Gene expression regulated)
Chemical causes of Hypothyroidism Interferon exposure (from Hep B/C) - risk of autoimmune disorder Lithium (bipolar treatment) Amiloroderon - decreases Iodide intake by 37%
Hypothyroidism diagnosis Low T3 and T4 High TSH Tg Ab presence (autoantibody presence) Hyper cholesterolaemia as thyroid increase LDLR expression)
Soloxinr (levothyroxine sodium, T4) Given orally Standard replacement therapy for hypothyroidism
Tetroxin (tri-iodothyronine, liothyronine, T3) Hypothyroidism replacement therapy
NI/KI For iodide deficiency in hypothyroidism
T3 metabolism Max levels achieved in 1 day More potent
T4 metabolism Slow Max levels achieved at day 10 More prevalent
Hyperthyroidism diagnosis Symptoms Goitre/mass Increased T4 levels Decreased TSH levels
Thiureylenes Thyroperoxidase inhibitor Inhibits T3/4 secretion
Thiureylenes Thyroperoxidase inhibitor Inhibits T3/4 secretion
Carbimazole Thyroperoxidase inhibitor Inhibits T3/4 secretion
High Iodide doses Hyperthyroidism treatment Reduced T3/4 synthesis and release - used acutely
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