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Benign prostatic hyperplasia
- Anatomy of prostate
- Histology of prostate
- Development of prostate
- prostate arises from
a budding collection
of tissue in the
urogenital sinus.
- The prostate develops from
epithelial outgrowths form
the prostatic segment of the
urethra that grows into the
surrounding mesenchyme.
- This outgrowth and
branching start at week 10
during embryo growth; by
week 12, there are 5
groups of tubules that
form the lobes of the
prostate.
- This outgrowth and
branching start at week 10
during embryo growth; by
week 12, there are 5
groups of tubules that
form the lobes of the
prostate.
- prostate arises from
a budding collection
of tissue in the
urogenital sinus.
- Funtion of prostate
- Production of seminal fluid
- Production of seminal fluid
- Risk factors of BPH
- Age
- Occurs in 20% of men over 40
- Occurs in 90% of men over 70
- Occurs in 20% of men over 40
- Lifestyle
- Family History
- Race
- Diabetes and heart disease
- others
- Age
- Signs and symptoms of BPH
- Hesitancy
- Frequency
- Dribbling
- bladder
hypertrophy
- my cause
obstruction
- Frequent UTI
- Hesitancy
- Investigations of BPH
- PSA
- produced by the prostate gland.
- is a 33-kd protein consisting of a
single-chain glycoprotein of 237 amino
acid residues, 4 carbohydrate side chains,
and multiple disulfide bonds.
- produced by the prostate gland.
- DRE
- CBC
- Urinary flow test
- Postvoid Residual volume test
- 24 hour voiding diary
- Transrectal
Ultrasound
- Prostate Biopsy
- Urodynamic
and pressure
flow studies
- Cystoscopy
- PSA
- BPH histology
- Nodular hyperplasia
- Transitional zone
- Urethra compressed into slit
- Nodular hyperplasia
- BPH Pathophysiology
- Proliferation of both epithelial and stromal elements
- Both androgens and estrogens may play a role
- Relative increase in estrogens in older men
may increase DHT receptors in prostate
- Proliferation of both epithelial and stromal elements
- BPH Treatment
- Pharmacology
- Surgical management
- Transurethral resection of the prostate
- Open prostatectomy
- Transurethral resection of the prostate
- Pharmacology
- prostate cancer
- Malignant
prolifration of
prostatic glands
- Spread to
lumbar spine or
pelvis is
common
- Spread to
lumbar spine or
pelvis is
common
- most common cancer in men
- second most common cause of cancer death
- second most common cause of cancer death
- Risk factors
- Age
- race
- African american
- African american
- diet high in saturated fat
- Age
- arise in the posterior peripheral region
- doesnt produce urinary symptoms early
- doesnt produce urinary symptoms early
- screening beins at the agae of 50 with DRE and PSA
- Decreased % free PSA suggest cancer
- Biopsy is required to confirm
- Shows small invasive glands with prominent nucleoli
- Shows small invasive glands with prominent nucleoli
- Biopsy is required to confirm
- Decreased % free PSA suggest cancer
- Gleason grading system
- Treatment
- Prostatectomy
- GnHR analogs
- leuprolide
- leuprolide
- Flutamide
- Prostatectomy
- Malignant
prolifration of
prostatic glands
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