Recent developments in GPCR signalling

Signalling pathway activated by a receptor in a cell is context specific
1. In different cells in the body or in the same cell at different times, different things are happening
2. Results in greater control over physiological outcome
Specific signalling is regulated by
1. Adaptor proteins
2. Scaffold proteins
  1. Play an important role in bringing receptors together with certain pathways
3. Lipids (Association with rafts/lipid microdomains)
4. Endocytosis
5. Splicing
6. Post-translational modifications
Regulation through interacting proteins
1. RAMPS
2. GRKs
  1. 7 types
3. B-arrestins
  1. 4 types
4. RGS proteins
Therapeutic potential of agonist-biased signalling
1. Does μ-opioid receptor (MOR) desensitization and trafficking have any role in tolerance?

Resumen del Recurso

	Creado por Kristi Brogden hace alrededor de 11 años