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17884589
Muhammed’s Spleen is Palpable
Descripción
Mapa Mental sobre Muhammed’s Spleen is Palpable, creado por Hyatt Alraeesi el 29/04/2019.
Mapa Mental por
Hyatt Alraeesi
, actualizado hace más de 1 año
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Creado por
Hyatt Alraeesi
hace casi 6 años
16
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Resumen del Recurso
Muhammed’s Spleen is Palpable
Epidemiology
BY RACE & ETHNICITY
White people
BY AGE GROUP
65-74
% surviving 5 years
61.4%
Leukocytosis Vs Leukemia
both have High WBC count
Leukemia
Caused by genetic mutations
More severe
WBCs don’t function properly
Always pathological
Leukocytosis
Caused by infections
pathological or physiological effects
Less severe
WBCs function normally
pharmacology
Imatinib
Action
inihibiting tyrosine kinase enzyme
Side effects
nausea/vomiting/diarrhea
edema/skin rash
Administration
given orally and metabolized by CYP3A4
Dasatinib & Nilotinib
Administration
orally
Action
inihibiting tyrosine kinase enzyme
Used in
ALL
CML
high WBC count over 11,000 cells/mm3
Only one type of WBC is affected
Basophils
may occur in people with a history of underactive thyroid disease, known as hypothyroidism.
Monocytes
indicate the presence of chronic infection, an autoimmune or blood disorder, cancer.
Lymphocytes
lymphocytic leukocytosis. It may also be linked to specific lymphomas and leukemias.
Neutrophils
neutrophilic leukocytosis: This condition is a normal immune response, such as infection, injury,, some
Eosinophils
If a person registers high levels of eosinophils, the body might be reacting to a parasitic infection, allergen, or asthma
Causes
Allergy
Drugs
Polycythemia vera
Leukemia
Stress
Leukemoid Reaction
Normal response & subsides after eliminating the stressor
WBC count 15,000-100,00 cells/mm3.
Dohle bodies
High NAP/LAP scores
Toxic granulations
Genetic tests
PCR
using a blood sample or bone marrow cells To find the BCR-ABL fusion gene
(FISH)
FISH can be used to look for specific pieces of the BCRABL gene on chromosomes.
Types of leukemia
ACUTE leukemia
> 20% blasts in bone marrow
MYELOID
AML
gum infiltrates
Auer rods
15-60yrs
LYMPHOID
ALL
newborns-14yrs
B-ALL is more common
Dense chromatin is found in mature cells
CHRONIC leukemia
< 20% blasts in bone marrow
MYELOID
CML
25-60 yrs
Philadelphia chromosome
Splenomegaly
Causes
Cirrhosis
Cystic fibrosis
Cytomegalovirus
Lymphoma
Symptoms
Anemiaؤ
Fatigue
Frequent infections
Basophilia
LYMPHOID
CLL
common in adults
Asymptomatic
smudge cells
Recursos multimedia adjuntos
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