Antiphospholipid syndrome

Descripción

Mapa Mental sobre Antiphospholipid syndrome, creado por Laura Smitherman el 16/02/2015.
Laura Smitherman
Mapa Mental por Laura Smitherman, actualizado hace más de 1 año
Laura Smitherman
Creado por Laura Smitherman hace casi 10 años
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Resumen del Recurso

Antiphospholipid syndrome
  1. Cause
    1. autoimmune
      1. ?antiphospholipid antibodies
        1. lupus anticoagulant
          1. anti-cardiolipin
            1. anti-β2-glycoprotein-I
            2. complement and platelet activation
            3. genetic
              1. unknown
              2. presentation
                1. hypercoagulable state
                  1. venous
                    1. DVT
                      1. PE
                      2. arterial
                        1. stroke
                      3. pregnancy complications
                        1. stillbirth
                          1. miscarriage
                            1. preterm delivery
                              1. severe pre-eclampsia
                              2. Livedo reticularis
                                1. haemolytic anaemia
                                  1. thrombocytopenia
                                  2. Types
                                    1. Primary
                                      1. HLA-DR7
                                      2. Secondary
                                        1. risk factors
                                          1. associated with other autoimmune diseases e.g. SLE, RA
                                            1. HLA-B8, HLA-DR2, HLA-DR3
                                              1. ethnicity
                                                1. most common in young fertile women
                                            2. Management
                                              1. Lifestyle to reduce cardiovascular risks
                                                1. Thrombosis risk
                                                  1. Acute
                                                    1. Heparin
                                                    2. Long term
                                                      1. Warfarin (INR 2-3) or antiplatelet
                                                    3. In pregnancy
                                                      1. LMWH + aspirin
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