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Muscular fatigue
- Reversible disminuition caused by excercise
- Muscular glycogen depletion
- Ca2+ liberation diminished
- ATP depletion around transverse tubules
- ADP increasing in cytoplasm
- Muscular glycogen depletion
- Types of fatigue
- Central fatigue
- Occurs in the main nervous system
- Occurs in the main nervous system
- Periferic fatigue
- Is originated in a neuromuscular union
- Is originated in a neuromuscular union
- Central fatigue
- The destruction of mucular fibers is harmful
beacause the cannot divide and replace themselves
- Satellite cells
- Found around sarcolem and basal bases
- They form mioblasts that fuse with damaged muscular fibers
- Miostatine: negative paracrin
regulator in skeletic muscles
- Miostatine: negative paracrin
regulator in skeletic muscles
- Found around sarcolem and basal bases
- Satellite cells
- Duchenne muscular dystrophy
- Progresive muscular weakness
- Patient dies before 30 years of age
due to respiratory muscles
insufficiency
- Absence of distrofine, which welds the
actine with protiens from the cellular
membrane
- Progresive muscular weakness
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